829 research outputs found

    The LIFE Model v1.1

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    Extract: This document draws together feedback, discussion and review of the LIFE Model from a number of sources: 1. The LIFE and LIFE2 Project Teams, and the staff of their institutions 2. Feedback from review by independent economics expert 3. The LIFE Project Conference 4. Early adopters of the Life Model (particularly the Royal Danish Library, State Archives and the State and University Library, Denmark) The result is a revision of the LIFE Model which was first published in 2006 by the LIFE Project . In line with the objectives of the LIFE2 Project, this revision aims to: 1. fix outstanding anomalies or omissions in the Model 2. scope and define the Model and its components more precisely 3. facilitate useful and repeatable mapping and costing of digital lifecycles

    Lifecycle information for E-literature: an introduction to the second phase of the LIFE project

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    Introduction: The first phase of LIFE (Lifecycle Information For E-Literature) made a major contribution to understanding the long-term costs of digital preservation; an essential step in helping institutions plan for the future. The LIFE work models the digital lifecycle and calculates the costs of preserving digital information for future years. Organisations can apply this process in order to understand costs and plan effectively for the preservation of their digital collections The second phase of the LIFE Project, LIFE2, has refined the LIFE Model adding three new exemplar Case Studies to further build upon LIFE1. LIFE2 is an 18-month JISC-funded project between UCL (University College London) and The British Library (BL), supported by the LIBER Access and Preservation Divisions. LIFE1 was completed in April 2006. LIFE2 started in March 2007, and was completed in August 2008. This summary aims to give an overview of the LIFE Project, summarising some of the key outputs. There are four main areas discussed: 1 From LIFE1 to LIFE2 outlines some of the key findings from the first phase of the project as well as summarising the motivation behind this second phase. 2 The LIFE Model describes the current version of the model (version 2) which has been thoroughly updated from the first phase. 3 LIFE2 Case Studies describes the three new Case Studies for LIFE2. It does not include the results from the Case Studies (these are available in the overall LIFE2 Report), but offers some background on each of the studies as well as discussion of why they were chosen. 4 Findings and Conclusions outlines all of the findings and outputs from the entire project

    The LIFE2 final project report

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    Executive summary: The first phase of LIFE (Lifecycle Information For E-Literature) made a major contribution to understanding the long-term costs of digital preservation; an essential step in helping institutions plan for the future. The LIFE work models the digital lifecycle and calculates the costs of preserving digital information for future years. Organisations can apply this process in order to understand costs and plan effectively for the preservation of their digital collections The second phase of the LIFE Project, LIFE2, has refined the LIFE Model adding three new exemplar Case Studies to further build upon LIFE1. LIFE2 is an 18-month JISC-funded project between UCL (University College London) and The British Library (BL), supported by the LIBER Access and Preservation Divisions. LIFE2 began in March 2007, and completed in August 2008. The LIFE approach has been validated by a full independent economic review and has successfully produced an updated lifecycle costing model (LIFE Model v2) and digital preservation costing model (GPM v1.1). The LIFE Model has been tested with three further Case Studies including institutional repositories (SHERPA-LEAP), digital preservation services (SHERPA DP) and a comparison of analogue and digital collections (British Library Newspapers). These Case Studies were useful for scenario building and have fed back into both the LIFE Model and the LIFE Methodology. The experiences of implementing the Case Studies indicated that enhancements made to the LIFE Methodology, Model and associated tools have simplified the costing process. Mapping a specific lifecycle to the LIFE Model isn’t always a straightforward process. The revised and more detailed Model has reduced ambiguity. The costing templates, which were refined throughout the process of developing the Case Studies, ensure clear articulation of both working and cost figures, and facilitate comparative analysis between different lifecycles. The LIFE work has been successfully disseminated throughout the digital preservation and HE communities. Early adopters of the work include the Royal Danish Library, State Archives and the State and University Library, Denmark as well as the LIFE2 Project partners. Furthermore, interest in the LIFE work has not been limited to these sectors, with interest in LIFE expressed by local government, records offices, and private industry. LIFE has also provided input into the LC-JISC Blue Ribbon Task Force on the Economic Sustainability of Digital Preservation. Moving forward our ability to cost the digital preservation lifecycle will require further investment in costing tools and models. Developments in estimative models will be needed to support planning activities, both at a collection management level and at a later preservation planning level once a collection has been acquired. In order to support these developments a greater volume of raw cost data will be required to inform and test new cost models. This volume of data cannot be supported via the Case Study approach, and the LIFE team would suggest that a software tool would provide the volume of costing data necessary to provide a truly accurate predictive model

    Book Reviews

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    Strong dust processing in circumstellar discs around 6 RV Tauri stars. Are dusty RV Tauri stars all binaries?

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    We present extended Spectral Energy Distributions (SEDs) of seven classical RV Tauri stars, using newly obtained submillimetre continuum measurements and Geneva optical photometry supplemented with literature data. The broad-band SEDs show a large IR excess with a black-body slope at long wavelengths in six of the seven stars, R Sct being the noticeable exception. This long wavelength slope is best explained assuming the presence of a dust component of large grains in the circumstellar material. We show that the most likely distribution of the circumstellar dust around the six systems is that the dust resides in a disc. Moreover, very small outflow velocities are needed to explain the presence of dust near the sublimation temperature and we speculate that the discs are Keplerian. The structure and evolution of these compact discs are as yet not understood but a likely prerequisite for their formation is that the dusty RV Tauri stars are binaries.Comment: 10 pages, will be published in A&

    Expression of chemokine receptors CXCR1 and CXCR2 during cardiopulmonary bypass

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    AbstractObjective: This study investigated the effects of cardiopulmonary bypass on neutrophil expression of chemokine receptors, CXCR1 and CXCR2, and the β2 integrin CD11b. Methods: Ten patients undergoing coronary artery grafting with cardiopulmonary bypass were studied. Blood samples were collected preoperatively, before bypass, at termination of bypass, and 12 to 18 hours postoperatively. In vitro studies were performed on control subjects to determine changes in the surface expression of CXCR1, CXCR2, and CD11b on stimulation with interleukin 8. Receptor expression was measured by flow cytometry. Plasma levels of interleukin 8 from the patients were determined by enzyme-linked immunoassay. Results: After bypass, CXCR2 expression fell by 66% (P <.0001) and remained low postoperatively (P <.0001). CXCR1 expression persisted at preoperative levels. CD11b expression increased significantly after bypass (P <.0001), returning to prebypass levels postoperatively. In vitro studies showed a dose-related fall of both CXCR1 (P <.0001) and CXCR2 expression (P <.0001) and a significant rise in CD11b expression (P <.0001). Plasma interleukin 8 increased significantly after bypass (P <.0001), remaining elevated 12 to 18 hours postoperatively (P =.02). Correlations between interleukin 8 levels and CXCR2 expression (P <.0001) and CD11b expression (P <.03) were demonstrated. Conclusions: CXCR2 expression is significantly down-regulated after bypass; in contrast, CXCR1 expression remains unchanged. In addition, whereas interleukin 8 is an important determinant of both CXCR1 and CXCR2 expression in vitro, it only correlates with CXCR2 and CD11b expression in vivo. This has implications in the search for antagonists against CXC chemokines and their receptor

    Multi-location laser ignition using a spatial light modulator towards improving automotive gasoline engine performance

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    We report on a study into multi-location laser ignition (LI) with a Spatial Light Modulator (SLM), to improve the performance of a single cylinder automotive gasoline engine. Three questions are addressed: i/ How to deliver a multi-beam diffracted pattern into an engine cylinder, through a small opening, while avoiding clipping? ii/ How much incident energy can a SLM handle (optical damage threshold) and how many simultaneous beam foci could thus be created? ; iii/ Would the multi-location sparks created be sufficiently intense and stable to ignite an engine and, if so, what would be their effect on engine performance compared to single-location LI? Answers to these questions were determined as follows. Multi-beam diffracted patterns were created by applying computer generated holograms (CGHs) to the SLM. An optical system for the SLM was developed via modelling in ZEMAX, to cleanly deliver the multi-beam patterns into the combustion chamber without clipping. Optical damage experiments were carried out on Liquid Crystal on Silicon (LCoS) samples provided by the SLM manufacturer and the maximum safe pulse energy to avoid SLM damage found to be 60 mJ. Working within this limit, analysis of the multi-location laser induced sparks showed that diffracting into three identical beams gave slightly insufficient energy to guarantee 100% sparking, so subsequent engine experiments used 2 equal energy beams laterally spaced by 4 mm. The results showed that dual-location LI gave more stable combustion and higher engine power output than single-location LI, for increasingly lean air-fuel mixtures. The paper concludes by a discussion of how these results may be exploited

    Recommendations for building out mosquito-transmitted diseases in sub-Saharan Africa: the DELIVER mnemonic

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    In sub-Saharan Africa, most transmission of mosquito-transmitted diseases, such as malaria or dengue, occurs within or around houses. Preventing mosquito house entry and reducing mosquito production around the home would help reduce the transmission of these diseases. Based on recent research, we make key recommendations for reducing the threat of mosquito-transmitted diseases through changes to the built environment. The mnemonic, DELIVER, recommends the following best practices: (i) Doors should be screened, self-closing and without surrounding gaps; (ii) Eaves, the space between the wall and roof, should be closed or screened; (iii) houses should be Lifted above the ground; (iv) Insecticide-treated nets should be used when sleeping in houses at night; (v) houses should be Ventilated, with at least two large-screened windows to facilitate airflow; (vi) Environmental management should be conducted regularly inside and around the home; and (vii) Roofs should be solid, rather than thatch. DELIVER is a package of interventions to be used in combination for maximum impact. Simple changes to the built environment will reduce exposure to mosquito-transmitted diseases and help keep regions free from these diseases after elimination. This article is part of the theme issue ‘Novel control strategies for mosquito-borne diseases'
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