83 research outputs found
Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells
A theoretical framework to describe communication processes during medical disability assessment interviews
BACKGROUND: Research in different fields of medicine suggests that communication is important in physician-patient encounters and influences satisfaction with these encounters. It is argued that this also applies to the non-curative tasks that physicians perform, such as sickness certification and medical disability assessments. However, there is no conceptualised theoretical framework that can be used to describe intentions with regard to communication behaviour, communication behaviour itself, and satisfaction with communication behaviour in a medical disability assessment context. OBJECTIVE: The objective of this paper is to describe the conceptualization of a model for the communication behaviour of physicians performing medical disability assessments in a social insurance context and of their claimants, in face-to-face encounters during medical disability assessment interviews and the preparation thereof. CONCEPTUALIzATION: The behavioural model, based on the Theory of Planned Behaviour (TPB), is conceptualised for the communication behaviour of social insurance physicians and claimants separately, but also combined during the assessment interview. Other important concepts in the model are the evaluation of communication behaviour (satisfaction), intentions, attitudes, skills, and barriers for communication. CONCLUSION: The conceptualization of the TPB-based behavioural model will help to provide insight into the communication behaviour of social insurance physicians and claimants during disability assessment interviews. After empirical testing of the relationships in the model, it can be used in other studies to obtain more insight into communication behaviour in non-curative medicine, and it could help social insurance physicians to adapt their communication behaviour to their task when performing disability assessment
Dynamic relocalization of NHERF1 mediates chemotactic migration of ovarian cancer cells toward lysophosphatidic acid stimulation
NHERF1/EBP50 (Na+/H+ exchanger regulating factor 1; Ezrin-binding phosphoprotein of 50 kDa) organizes stable protein complexes beneath the apical membrane of polar epithelial cells. By contrast, in cancer cells without any fixed polarity, NHERF1 often localizes in the cytoplasm. The regulation of cytoplasmic NHERF1 and its role in cancer progression remain unclear. In this study, we found that, upon lysophosphatidic acid (LPA) stimulation, cytoplasmic NHERF1 rapidly translocated to the plasma membrane, and subsequently to cortical protrusion structures, of ovarian cancer cells. This movement depended on direct binding of NHERF1 to C-terminally phosphorylated ERM proteins (cpERMs). Moreover, NHERF1 depletion downregulated cpERMs and further impaired cpERM-dependent remodeling of the cell cortex, suggesting reciprocal regulation between these proteins. The LPA-induced protein complex was highly enriched in migratory pseudopodia, whose formation was impaired by overexpression of NHERF1 truncation mutants. Consistent with this, NHERF1 depletion in various types of cancer cells abolished chemotactic cell migration toward a LPA gradient. Taken together, our findings suggest that the high dynamics of cytosolic NHERF1 provide cancer cells with a means of controlling chemotactic migration. This capacity is likely to be essential for ovarian cancer progression in tumor microenvironments containing LPA
Sweat loss of nitrogen and other nutrients during heavy physical activity
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Myocardial changes in monkeys fed mustard oil
Three groups, each of eight adult male monkeys were maintained for a little over 1 year on diets containing 20 & percent; mustard oil, peanut
oil or hydrogenated peanut fat, respectively. Animals of the mustard oil group showed sarcoplasmic vacuolation of right and left ventricular myocardium. Half
the number of monkeys also exhibited a variable degree of myocardial fibrosis which involved the subepicardial zone of the right ventricular wall between the
tricuspid valve and apical region. That these changes were not the manifestations of a high fat intake per se was shown by the absence of such changes in the
hearts of the animals consuming similar amounts of peanut oil or hydrogenated peanut fat. The results indicated the possible hazards of consuming diets rich
in mustard oil for prolonged periods, which like rapeseed oil contains high amounts of erucic acid
Economic impact of compliance to treatment with antidiabetes medication in type 2 diabetes mellitus: a review paper
Shipborne measurements of ClNO<sub>2</sub> in the Mediterranean Sea and around the Arabian Peninsula during summer
Shipborne measurements of nitryl chloride (ClNO2), hydrogen chloride (HCl) and sulfur dioxide (SO2) were made during the AQABA (Air Quality and climate change in the Arabian BAsin) ship campaign in summer 2017. The dataset includes measurements over the Mediterranean Sea, the Suez Canal, the Red Sea, the Gulf of Aden, the Arabian Sea, the Gulf of Oman, and the Arabian Gulf (also known as Persian Gulf) with observed ClNO2 mixing ratios ranging from the limit of detection to ≈600 pptv. We examined the regional variability in the generation of ClNO2 via the uptake of dinitrogen pentoxide (N2O5) to Cl-containing aerosol and its importance for Cl atom generation in a marine boundary layer under the (variable) influence of emissions from shipping and the oil industry. The yield of ClNO2 formation per NO3 radical generated was generally low (median of ≈1 %-5 % depending on the region), mainly as a result of gas-phase loss of NO3 dominating over heterogeneous loss of N2O5, the latter being disfavoured by the high temperatures found throughout the campaign. The contributions of ClNO2 photolysis and OH-induced HCl oxidation to Cl-radical formation were derived and their relative contributions over the did cycle compared. The results indicate that over the northern Red Sea, the Gulf of Suez, and the Gulf of Oman the formation of Cl atoms will enhance the oxidation rates of some volatile organic compounds (VOCs), especially in the early morning
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