Indocyanine Green-Loaded Polydopamine-Reduced Graphene Oxide Nanocomposites with Amplifying Photoacoustic and Photothermal Effects for Cancer Theranostics

Photoacoustic (PA) imaging and photothermal therapy (PTT) as light-induced theranostic platforms have been attracted much attention in recent years. However, the development of highly efficient and integrated phototheranostic nanoagents for amplifying PA imaging and PTT treatments poses great challenges. Here, we report a novel phototheranostic nanoagent using indocyanine green-loaded polydopamine-reduced graphene oxide nanocomposites (ICG-PDA-rGO) with amplifying PA and PTT effects for cancer theranostics. The results demonstrate that the PDA layer coating on the surface of rGO could effectively absorb a large number of ICG molecules, quench ICG's fluorescence, and enhance the PDA-rGO's optical absorption at 780 nm. The obtained ICG-PDA-rGO exhibits stronger PTT effect and higher PA contrast than that of pure GO and PDA-rGO. After PA imaging-guided PTT treatments, the tumors in 4T1 breast subcutaneous and orthotopic mice models are suppressed completely and no treatment-induced toxicity being observed. It illustrates that the ICG-PDA-rGO nanocomposites constitute a new class of theranostic nanomedicine for amplifying PA imaging and PTT treatments

Indocyanine Green-Loaded Polydopamine-Reduced Graphene Oxide Nanocomposites with Amplifying Photoacoustic and Photothermal Effects for Cancer Theranostics

Photoacoustic (PA) imaging and photothermal therapy (PTT) as light-induced theranostic platforms have been attracted much attention in recent years. However, the development of highly efficient and integrated phototheranostic nanoagents for amplifying PA imaging and PTT treatments poses great challenges. Here, we report a novel phototheranostic nanoagent using indocyanine green-loaded polydopamine-reduced graphene oxide nanocomposites (ICG-PDA-rGO) with amplifying PA and PTT effects for cancer theranostics. The results demonstrate that the PDA layer coating on the surface of rGO could effectively absorb a large number of ICG molecules, quench ICG's fluorescence, and enhance the PDA-rGO's optical absorption at 780 nm. The obtained ICG-PDA-rGO exhibits stronger PTT effect and higher PA contrast than that of pure GO and PDA-rGO. After PA imaging-guided PTT treatments, the tumors in 4T1 breast subcutaneous and orthotopic mice models are suppressed completely and no treatment-induced toxicity being observed. It illustrates that the ICG-PDA-rGO nanocomposites constitute a new class of theranostic nanomedicine for amplifying PA imaging and PTT treatments

Cell-Membrane Biomimetic Indocyanine Green Liposomes for Phototheranostics of Echinococcosis

Echinococcosis is an important zoonotic infectious disease that seriously affects human health. Conventional diagnosis of echinococcosis relies on the application of large-scale imaging equipment, which is difficult to promote in remote areas. Meanwhile, surgery and chemotherapy for echinococcosis can cause serious trauma and side effects. Thus, the development of simple and effective treatment strategies is of great significance for the diagnosis and treatment of echinococcosis. Herein, we designed a phototheranostic system utilizing neutrophil-membrane-camouflaged indocyanine green liposomes (Lipo-ICG) for active targeting the near-infrared fluorescence diagnosis and photothermal therapy of echinococcosis. The biomimetic Lipo-ICG exhibits a remarkable photo-to-heat converting performance and desirable active-targeting features by the inflammatory chemotaxis of the neutrophil membrane. In-vitro and in-vivo studies reveal that biomimetic Lipo-ICG with high biocompatibility can achieve in-vivo near-infrared fluorescence imaging and phototherapy of echinococcosis in mouse models. Our research is the first to apply bionanomaterials to the phototherapy of echinococcosis, which provides a new standard for the convenient and noninvasive detection and treatment of zoonotic diseases

Through Scalp and Skull NIR-II Photothermal Therapy of Deep Orthotopic Brain Tumors with Precise Photoacoustic Imaging Guidance

10.1002/adma.201802591ADVANCED MATERIALS303

Biocompatible conjugated polymer nanoparticles for highly efficient photoacoustic imaging of orthotopic brain tumors in the second near-infrared window

10.1039/c7mh00672aMaterials Horizons461151-115

Photoluminescent 3D Lanthanide–Organic Frameworks Based on 2,5-Dioxo-1,4-piperazinylbis(methylphosphonic) Acid Formed via in Situ Cyclodehydration of Glyphosates

Hydrothermal reactions of lanthanide nitrates with glyphosate have resulted three new isostructural 3D lanthanide–organic frameworks, Ln­(NO₃)­(H₂L) [Ln = Eu (<b>1</b>), Tb (<b>2</b>), Gd (<b>3</b>); H₄L = 2,5-dioxo-1,4-piperazinylbis­(methylphosphonic) acid], with good yields, where H₄L as a new ligand was formed via in situ cyclodehydration of original ligand glyphosates during the hydrothermal reaction. The compounds were thoroughly characterized by IR, UV–vis, elemental analysis, single-crystal X-ray diffraction analysis, powder X-ray diffraction analysis, and thermogravimetric/differential thermal analysis (TG-DTA). Three compounds display 3D 6,6-connected open frameworks with 4¹³·6² topology possessing 1D channels in which NO₃^– anions act as troglodytes by chelating Ln³⁺ centers. The TG-DTA study of the compounds showed remarkable thermal stability up to 380 °C. Under room temperature UV-light irradiation, the Eu³⁺ and Tb³⁺ compounds showed the corresponding characteristic Ln³⁺ intra 4f^<i>n</i> emission peaks. The triplet energy level (21882 cm^–1) of the ligand (H₄L) was determined from the emission spectrum of its Gd³⁺ compound at 77 K. The emission lifetimes (1.54 ms of ⁵D₀ for compound <b>1</b> and 1.98 ms of ⁵D₄ for compound <b>2</b>) and absolute emission quantum yields (10.1% for compound <b>1</b> and 5.9% for compound <b>2</b>) were also determined

Photoluminescent 3D Lanthanide–Organic Frameworks Based on 2,5-Dioxo-1,4-piperazinylbis(methylphosphonic) Acid Formed via in Situ Cyclodehydration of Glyphosates

Hydrothermal reactions of lanthanide nitrates with glyphosate have resulted three new isostructural 3D lanthanide–organic frameworks, Ln­(NO₃)­(H₂L) [Ln = Eu (<b>1</b>), Tb (<b>2</b>), Gd (<b>3</b>); H₄L = 2,5-dioxo-1,4-piperazinylbis­(methylphosphonic) acid], with good yields, where H₄L as a new ligand was formed via in situ cyclodehydration of original ligand glyphosates during the hydrothermal reaction. The compounds were thoroughly characterized by IR, UV–vis, elemental analysis, single-crystal X-ray diffraction analysis, powder X-ray diffraction analysis, and thermogravimetric/differential thermal analysis (TG-DTA). Three compounds display 3D 6,6-connected open frameworks with 4¹³·6² topology possessing 1D channels in which NO₃^– anions act as troglodytes by chelating Ln³⁺ centers. The TG-DTA study of the compounds showed remarkable thermal stability up to 380 °C. Under room temperature UV-light irradiation, the Eu³⁺ and Tb³⁺ compounds showed the corresponding characteristic Ln³⁺ intra 4f^<i>n</i> emission peaks. The triplet energy level (21882 cm^–1) of the ligand (H₄L) was determined from the emission spectrum of its Gd³⁺ compound at 77 K. The emission lifetimes (1.54 ms of ⁵D₀ for compound <b>1</b> and 1.98 ms of ⁵D₄ for compound <b>2</b>) and absolute emission quantum yields (10.1% for compound <b>1</b> and 5.9% for compound <b>2</b>) were also determined

Magneto-Plasmonic Nanocapsules for Multimodal-Imaging and Magnetically Guided Combination Cancer Therapy

Integrating multiple discrete functionalities into hollow-mesoporous architecture with distinctive electronic/magnetic property is of particular interest for building multifunctional drug carriers with complementary theranostic modalities. In this article, the “non-contact” incorporation of gold nanorod (GNR) into porous magnetic nanoshell is achieved via yolk–shell structure, which was intrinsically different from previous direct chemical or heterogeneous conjugation of the two components. The highly preserved plasmonic feature of GNRs enabled photothermal induced photoacoustic imaging and hyperthermia capabilities. The magnetic shell consisted of stacked primary iron oxide nanocrystals yields strong superparamagnetic response with excellent permeability for magnetically targeted drug delivery. Interestingly, the special coordination between doxorubicin and iron species enabled pH/local heating dual-responsive drug release with minor leakage at neutral pH. Under the guidance of magnetic resonance/photoacoustic dual-modal imaging and magnetically tumor targeting using the nanoagents, the photothermal-chemo synergistic therapy was conducted via near-infrared laser for highly efficient tumor eradication