Spatial popularity and similarity of watching videos in a large city

With the popularity of watching mobile videos, many works focus on the geographic features of user viewing behaviors, but few study them in the context of an entire metropolitan city. Different regions of a large city have different intensity of economy activities with respect to their different distances to the downtown, and how this will influence video popularity and similarity is still unclear. To quantitatively study the spatial popularity and similarity of watching videos in a large urban environment, we collect a dataset with two-month video view requests from the largest network provider in Shanghai, containing top six content providers, and study the spatial features of video access in regions of different scales. We find that 1) video popularity and similarity exist at different scales of city division; 2) the concentration of video popularity becomes higher as the region is closer to downtown; 3) when comparing the regions of same scale, the similarity of popular videos becomes lower as the region is farther away from the downtown. Finally, we correlate our findings with cache deployment, advertising and video recommendation to illustrate the implication

Probing the R-parity violating supersymmetric effects in the exclusive c→d/sℓνℓc\to d/s\ell\nu_\ell decays

A lot of branching ratios of the exclusive $c \to d/s\ell\nu_\ell$ ($\ell=e,\mu$) decays have been quite accurately measured by CLEO-c, BELLE, BABAR, BES(I,II,III), ALEPH and MARKIII collaborations. We probe the R-parity violating supersymmetric effects in the exclusive $c \to d/s\ell\nu_\ell$ decays. From the latest experimental measurements, we obtain new upper limits on the relevant R-parity violating coupling parameters within the decays, and many upper limits are obtained for the first time. Using the constrained new parameter spaces, we predict the R-parity violating effects on the observables, which have not been measured or have not been well measured yet. We find that the R-parity violating effects due to slepton exchange could be large on the branching ratios of $D_{d/s}\to e\nu_e$ decays and the normalized forward-backward asymmetries of $D_{u/d}\to \pi/K \ell\nu_\ell$ as well as $D_s\to K \ell\nu_\ell$ decays, and all branching ratios of the relevant semileptonic $D$ decays are sensitive to squark exchange couplings. Our results in this work could be used to probe new physics effects in the leptonic decays as well as the semileptonic decays, and will correlate with searches for direct supersymmetric signals at LHC and BESIII.Comment: 26 pages, 13 figure

FAM129B, an antioxidative protein, reduces chemosensitivity by competing with Nrf2 for Keap1 binding.

BackgroundThe transcription factor Nrf2 is a master regulator of antioxidant response. While Nrf2 activation may counter increasing oxidative stress in aging, its activation in cancer can promote cancer progression and metastasis, and confer resistance to chemotherapy and radiotherapy. Thus, Nrf2 has been considered as a key pharmacological target. Unfortunately, there are no specific Nrf2 inhibitors for therapeutic application. Moreover, high Nrf2 activity in many tumors without Keap1 or Nrf2 mutations suggests that alternative mechanisms of Nrf2 regulation exist.MethodsInteraction of FAM129B with Keap1 is demonstrated by immunofluorescence, colocalization, co-immunoprecipitation and mammalian two-hybrid assay. Antioxidative function of FAM129B is analyzed by measuring ROS levels with DCF/flow cytometry, Nrf2 activation using luciferase reporter assay and determination of downstream gene expression by qPCR and wester blotting. Impact of FAM129B on in vivo chemosensitivity is examined in mice bearing breast and colon cancer xenografts. The clinical relevance of FAM129B is assessed by qPCR in breast cancer samples and data mining of publicly available databases.FindingsWe have demonstrated that FAM129B in cancer promotes Nrf2 activity by reducing its ubiquitination through competition with Nrf2 for Keap1 binding via its DLG and ETGE motifs. In addition, FAM129B reduces chemosensitivity by augmenting Nrf2 antioxidative signaling and confers poor prognosis in breast and lung cancer.InterpretationThese findings demonstrate the important role of FAM129B in Nrf2 activation and antioxidative response, and identify FMA129B as a potential therapeutic target. FUND: The Chang Gung Medical Foundation (Taiwan) and the Ministry of Science and Technology (Taiwan)

Analysis of operation performance of three indirect expansion solar assisted air source heat pumps for domestic heating

To achieve the goal set for net-zero emissions of greenhouse gases in the UK by 2050, the domestic heating must be decarbonised. Solar assisted air source heat pumps, integrating solar collector, thermal energy storage tank and heat pump, offers a promising alternative application under the UK weather conditions. Literature review shows that investigations of solar assisted air source heat pumps in the regions like the UK are still insufficient. The serial, parallel and dual-source indirect expansion solar assisted air source heat pumps are modelled and simulated under the weather conditions in London using TRNSYS to investigate the operation performance over a typical year. These three heat pumps are applied to provide space heating and hot water of 300 L per day for a typical single-family house. The simulation results show comparisons of the three systems. The serial type heat pump shows the highest seasonal performance factor of 5.5, but requiring the largest sizes of the solar collector and thermal energy storage tank. The dual-source and parallel type heat pumps show slightly lower seasonal performance factors of 4.4 and 4.5, respectively, requiring smaller sizes of solar collector and thermal energy storage tank. Furthermore, the results show that the air source part contributes to an important proportion of the heat provision and stable operation of the systems. The yearly seasonal performance factor higher than 4.4 achievable by the three heat pumps suggests that they are potentially applied in the regions with relatively lower solar irradiance. The economic analyses indicate that the parallel and dual-source type heat pumps provide good alternatives to replace the gas-boiler heating system

Japanese Encephalitis, Singapore

10.3201/eid1203.051251Emerging Infectious Diseases123525-52

ABSCISIC ACID-INSENSITIVE 5-KIP-RELATED PROTEIN 1-SHOOT MERISTEMLESS modulates reproductive development of Arabidopsis

Soil (or plant) water deficit accelerates plant reproduction. However, the underpinning molecular mechanisms remain unknown. By modulating cell division/number, ABSCISIC ACID-INSENSITIVE 5 (ABI5), a key bZIP (basic (region) leucine zippers) transcription factor, regulates both seed development and abiotic stress responses. The KIP-RELATED PROTEIN (KRP) cyclin-dependent kinases (CDKs) play an essential role in controlling cell division, and SHOOT MERISTEMLESS (STM) plays a key role in the specification of flower meristem identity. Here, our findings show that abscisic acid (ABA) signaling and/or metabolism in adjust reproductive outputs (such as rosette leaf number and open flower number) under water-deficient conditions in Arabidopsis (Arabidopsis thaliana) plants. Reproductive outputs increased under water-sufficient conditions but decreased under water-deficient conditions in the ABA signaling/metabolism mutants abscisic acid2-1 (aba2-1), aba2-11, abscisic acid insensitive3-1 (abi3-1), abi4-1, abi5-7, and abi5-8. Further, under water-deficient conditions, ABA induced-ABI5 directly bound to the promoter of KRP1, which encodes a CDK that plays an essential role in controlling cell division, and this binding subsequently activated KRP1 expression. In turn, KRP1 physically interacted with STM, which functions in the specification of flower meristem identity, promoting STM degradation. We further demonstrate that reproductive outputs are adjusted by the ABI5–KRP1–STM molecular module under water-deficient conditions. Together, our findings reveal the molecular mechanism by which ABA signaling and/or metabolism regulate reproductive development under water-deficient conditions. These findings provide insights that may help guide crop yield improvement under water deficiency