528 research outputs found
The effect of personality on collaborative task performance and interaction
Collocated, multi-user technologies, which support group-work are becoming increasingly popular. Examples include MERL's Diamondtouch and Microsoft's Surface, both of which have evolved from research prototypes to commercial products. Many applications have been developed for such technologies which support the work and entertainment needs of small groups of people. None of these applications however, have been studied in terms of the interactions and performances of their users with regards to their personality. In this paper, we address this research gap by conducting a series of user studies involving dyads working on a number of multi-user applications on the DiamondTouch tabletop device
Magnetic resonance imaging of glutamate in neuroinflammation
AbstractInflammation in central nervous system (CNS) is one of the most severe diseases, and also plays an impellent role in some neurodegenerative diseases. Glutamate (Glu) has been considered relevant to the pathogenesis of neuroinflammation. In order to diagnose neuroinflammation incipiently and precisely, we review the pathobiological events in the early stages of neuroinflammation, the interactions between Glu and neuroinflammation, and two kinds of magnetic resonance techniques of imaging Glu (chemical exchange saturation transfer and magnetic resonance spectroscopy)
Antiferromagnetic Heisenberg model on anisotropic triangular lattice in the presence of magnetic field
We use Schwinger boson mean field theory to study the antiferromagnetic
spin-1/2 Heisenberg model on an anisotropic triangular lattice in the presence
of a uniform external magnetic field. We calculate the field dependence of the
spin incommensurability in the ordered spin spiral phase, and compare the
results to the recent experiments in CsCuCl by Coldea et al. (Phys.
Rev. Lett. 86, 1335 (2001)).Comment: 4 pages with 4 figures include
Some effects of different constitutive laws on simulating mitral valve dynamics with FSI
In this paper, three different constitutive laws for mitral leaflets and two laws for chordae tendineae are selected to study their effects on mitral valve dynamics with fluid-structure interaction. We first fit these three mitral leaflet constitutive laws and two chordae tendineae laws with experimental data. The fluid-structure interaction is implemented in an immersed boundary framework with finite element extension for solid, that is the hybrid immersed boundary/finite element(IB/FE) method. We specifically compare the fluid-structure results of different constitutive laws since fluid-structure interaction is the physiological loading environment. This allows us to look at the peak jet velocity, the closure regurgitation volume, and the orifice area. Our numerical results show that different constitutive laws can affect mitral valve dynamics, such as the transvalvular flow rate, closure regurgitation and the orifice area, while the differences in fiber strain and stress are insignificant because all leaflet constitutive laws are fitted to the same set of experimental data. In addition, when an exponential constitutive law of chordae tendineae is used, a lower closure regurgitation flow is observed compared to that of a linear material model. In conclusion, combining numerical dynamic simulations and static experimental tests, we are able to identify suitable constitutive laws for dynamic behaviour of mitral leaflets and chordae under physiological conditions
Scaling Exponents in Anisotropic Hydrodynamic Turbulence
In anisotropic turbulence the correlation functions are decomposed in the
irreducible representations of the SO(3) symmetry group (with different
"angular momenta" ). For different values of the second order
correlation function is characterized by different scaling exponents
. In this paper we compute these scaling exponents in a Direct
Interaction Approximation (DIA). By linearizing the DIA equations in small
anisotropy we set up a linear operator and find its zero-modes in the inertial
interval of scales. Thus the scaling exponents in each -sector follow
from solvability condition, and are not determined by dimensional analysis. The
main result of our calculation is that the scaling exponents
form a strictly increasing spectrum at least until , guaranteeing that
the effects of anisotropy decay as power laws when the scale of observation
diminishes. The results of our calculations are compared to available
experiments and simulations.Comment: 10 pages, 4 figures, PRE submitted. Fixed problems with figure
Flat-Band Ferromagnetism in Organic Polymers Designed by a Computer Simulation
By coupling a first-principles, spin-density functional calculation with an
exact diagonalization study of the Hubbard model, we have searched over various
functional groups for the best case for the flat-band ferromagnetism proposed
by R. Arita et al. [Phys. Rev. Lett. {\bf 88}, 127202 (2002)] in organic
polymers of five-membered rings. The original proposal (poly-aminotriazole) has
turned out to be the best case among the materials examined, where the reason
why this is so is identified here. We have also found that the ferromagnetism,
originally proposed for the half-filled flat band, is stable even when the band
filling is varied away from the half-filling. All these make the ferromagnetism
proposed here more experimentally inviting.Comment: 11 pages, 13figure
Ultrasound attenuation in gap-anisotropic systems
Transverse ultrasound attenuation provides a weakly-coupled probe of momentum
current correlations in electronic systems. We develop a simple theory for the
interpretation of transverse ultrasound attenuation coefficients in systems
with nodal gap anisotropy. Applying this theory we show how ultrasound can
delineate between extended-s and d-wave scenarios for the cuprate
superconductors.Comment: Uuencode file: 4 pages (Revtex), 3 figures. Some references adde
Interplanetary and Geomagnetic Consequences of Interacting CMEs of 13-14 June 2012
We report on the kinematics of two interacting CMEs observed on 13 and 14
June 2012. Both CMEs originated from the same active region NOAA 11504. After
their launches which were separated by several hours, they were observed to
interact at a distance of 100 Rs from the Sun. The interaction led to a
moderate geomagnetic storm at the Earth with Dst index of approximately, -86
nT. The kinematics of the two CMEs is estimated using data from the Sun Earth
Connection Coronal and Heliospheric Investigation (SECCHI) onboard the Solar
Terrestrial Relations Observatory (STEREO). Assuming a head-on collision
scenario, we find that the collision is inelastic in nature. Further, the
signatures of their interaction are examined using the in situ observations
obtained by Wind and the Advance Composition Explorer (ACE) spacecraft. It is
also found that this interaction event led to the strongest sudden storm
commencement (SSC) (approximately 150 nT) of the present Solar Cycle 24. The
SSC was of long duration, approximately 20 hours. The role of interacting CMEs
in enhancing the geoeffectiveness is examined.Comment: 17 pages, 5 figures, Accepted in Solar Physics Journa
Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer.
Drug combinations can improve angiostatic cancer treatment efficacy and enable the reduction of side effects and drug resistance. Combining drugs is non-trivial due to the high number of possibilities. We applied a feedback system control (FSC) technique with a population-based stochastic search algorithm to navigate through the large parametric space of nine angiostatic drugs at four concentrations to identify optimal low-dose drug combinations. This implied an iterative approach of in vitro testing of endothelial cell viability and algorithm-based analysis. The optimal synergistic drug combination, containing erlotinib, BEZ-235 and RAPTA-C, was reached in a small number of iterations. Final drug combinations showed enhanced endothelial cell specificity and synergistically inhibited proliferation (p < 0.001), but not migration of endothelial cells, and forced enhanced numbers of endothelial cells to undergo apoptosis (p < 0.01). Successful translation of this drug combination was achieved in two preclinical in vivo tumor models. Tumor growth was inhibited synergistically and significantly (p < 0.05 and p < 0.01, respectively) using reduced drug doses as compared to optimal single-drug concentrations. At the applied conditions, single-drug monotherapies had no or negligible activity in these models. We suggest that FSC can be used for rapid identification of effective, reduced dose, multi-drug combinations for the treatment of cancer and other diseases
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