Effects of Medication on Respiration Pattern of Tranquilized White Mice

White mice of varying ages were given a definite amount of the tranquilizer, reserpine, over a three-week period. At the end of this period, respiration rates were determined by use of a physiograph with impedance pneumograph and small animal attachments. Mice were given, in addition to the tranquilizer, varying dosages of different medicinals, and their respiratory pattern was recorded. Such medicinals as thyroxin, streptomycin, vitamins E and C were given and in combination with sulfanilamide, nicotinamide, neonal, kayquinone, hykenone. Effects of multiple medications were noted and recorded. Reserpine, when given in all combinations, lowered the respiratory rate from that recorded when each drug was given alone. Vitamin C gave a stabilizing effect to the respiratory pattern when given in combination with other medications

Some Effects of Thyroxine-Reserpine Treatment on Growth of Mice

Thyroxine, reserpine, and a combination of the two drugs were given to white mice over a ten-week period. Effects on growth rate were noted. Data are presented which indicate that a sequence of thyroxine for two days and reserpine for one day, with the sequence repeated over the experimental period, proved to have greatest effect on growth rate

Radioisotope Distribution in Visceral Organs of White Mice

White mice, previously medicated over a three week period with reserpine, thyroxine, ascorbic acid and streptomycin were given 0.3 Microcurie or radioactive phosphorus³² by intramuscular injection. After 24 hours the mice were sacrificed, ten organs removed, and the amount of radioactivity retained was recorded in counts per minute per gram. Results showed males retained more of the isotope than females in all organs except gonads and brain. Liver, intestine, and kidney retained more of the isotope than other organs with each medication. With the reserpine medicated animals there was less radioactivity retained by ten organs. The control group had the next most, followed by ascorbic acid, and streptomycin-medicated animals. Greatest retention of the isotope was in the thryoxin-medicated groups

Effect of Multiple Medication on Hemoglohlin Content in Tranquilized Mice

Varying doses of medication were given tranquilized white mice. The hemoglobin content was measured by means of a Spectronic 20 colorimeter, using the Cannan chemical technique, with percent transmittance from colorimeter reading plotted against concentration grams per hemoglobin per 100 ml. blood of the standard. Comparison of length of medication, dosage, sex of animals, age of animals, and length of time on tranquilizer before medication was started recorded. Included in medication were varying amounts of sex hormones, and effects noted