The “New” Ticket to Work and Self-Sufficiency Program: Enhancing Economic Self-Sufficiency of Beneficiaries through Work Opportunities and Public/Private Partnership

Discusses the history of the Social Security Administration’s Vocational Rehabilitation and describes the intents and functioning of the Ticket to Work and work Incentives Improvement Act of 1999. This publication is based on federal Social Security and Supplemental Security Income (SSI) laws, regulations and policy. Following Sections I and II pertaining to historical context and evolution of SSA and the Ticket, information presented regarding the operations and structure of the Ticket to Work and Self-Sufficiency Program is based exclusively on the new 2008 regulations

T-Branes at the Limits of Geometry

Singular limits of 6D F-theory compactifications are often captured by T-branes, namely a non-abelian configuration of intersecting 7-branes with a nilpotent matrix of normal deformations. The long distance approximation of such 7-branes is a Hitchin-like system in which simple and irregular poles emerge at marked points of the geometry. When multiple matter fields localize at the same point in the geometry, the associated Higgs field can exhibit irregular behavior, namely poles of order greater than one. This provides a geometric mechanism to engineer wild Higgs bundles. Physical constraints such as anomaly cancellation and consistent coupling to gravity also limit the order of such poles. Using this geometric formulation, we unify seemingly different wild Hitchin systems in a single framework in which orders of poles become adjustable parameters dictated by tuning gauge singlet moduli of the F-theory model.Comment: v2: 65 pages, 6 figures, clarifications adde

Effects of P-wave Annihilation on the Angular Power Spectrum of Extragalactic Gamma-rays from Dark Matter Annihilation

We present a formalism for estimating the angular power spectrum of extragalactic gamma-rays produced by dark matter annihilating with any general velocity-dependent cross section. The relevant density and velocity distribution of dark matter is modeled as an ensemble of smooth, universal, rigid, disjoint, spherical halos with distribution and universal properties constrained by simulation data. We apply this formalism to theories of dark matter with p-wave annihilation, for which the relative-velocity-weighted annihilation cross section is \sigma v=a+bv^2. We determine that this significantly increases the gamma-ray power if b/a >> 10^6. The effect of p-wave annihilation on the angular power spectrum is very similar for the sample of particle physics models we explored, suggesting that the important effect for a given b/a is largely determined by the cosmic dark matter distribution. If the dark matter relic from strong p-wave theories is thermally produced, the intensities of annihilation gamma-rays are strongly p-wave suppressed, making them difficult to observe. If an angular power spectrum consistent with a strong p-wave were to be observed, it would likely indicate non-thermal production of dark matter in the early Universe.Comment: 20 pages, 3 figure

The effect of low-dose pre-operative X-irradiation of implanted mouse mammary carcinomas on local recurrence and metastasis.

Pre-operative X-irradiation of s.c. implanted first-generation mammary tumours in C3H mice, using either 500 rad or two fractions of 350 rad, produced no improvement in the success of surgery in causing local control or in reduction of distant metastases. The metastasis rate was just significantly higher after the two-fraction treatment of the implanted tumour than after surgical removal alone. The results are in agreement with previously published results on carcinomas and a sarcoma but contrast with those for murine lymphomas

Prevention of hormone action by local application of actinomycin D

This article does not have an abstract

What's the evidence that NICE guidance has been implemented? Results from a national evaluation using time series analysis, audit of patients' notes, and interviews

OBJECTIVES: To assess the extent and pattern of implementation of guidance issued by the National Institute for Clinical Excellence (NICE). DESIGN: Interrupted time series analysis, review of case notes, survey, and interviews. SETTING: Acute and primary care trusts in England and Wales. PARTICIPANTS: All primary care prescribing, hospital pharmacies; a random sample of 20 acute trusts, 17 mental health trusts, and 21 primary care trusts; and senior clinicians and managers from five acute trusts. MAIN OUTCOME MEASURES: Rates of prescribing and use of procedures and medical devices relative to evidence based guidance. RESULTS: 6308 usable patient audit forms were returned. Implementation of NICE guidance varied by trust and by topic. Prescribing of some taxanes for cancer (P <0.002) and orlistat for obesity (P <0.001) significantly increased in line with guidance. Prescribing of drugs for Alzheimer’s disease and prophylactic extraction of wisdom teeth showed trends consistent with, but not obviously a consequence of, the guidance. Prescribing practice often did not accord with the details of the guidance. No change was apparent in the use of hearing aids, hip prostheses, implantable cardioverter defibrillators, laparoscopic hernia repair, and laparoscopic colorectal cancer surgery after NICE guidance had been issued. CONCLUSIONS: Implementation of NICE guidance has been variable. Guidance seems more likely to be adopted when there is strong professional support, a stable and convincing evidence base, and no increased or unfunded costs, in organisations that have established good systems for tracking guidance implementation and where the professionals involved are not isolated. Guidance needs to be clear and reflect the clinical context

The estrogenic activity of phthalate esters in vitro

A large number of phthalate esters were screened for estrogenic activity using a recombinant yeast screen. a selection of these was also tested for mitogenic effect on estrogen-responsive human breast cancer cells. A small number of the commercially available phthalates tested showed extremely weak estrogenic activity. The relative potencies of these descended in the order butyl benzyl phthalate (BBP) > dibutyl phthalate (DBP) > diisobutyl phthalate (DIBP) > diethyl phthalate (DEP) > diisiononyl phthalate (DINP). Potencies ranged from approximately 1 x 10(6) to 5 x 10(7) times less than 17beta-estradiol. The phthalates that were estrogenic in the yeast screen were also mitogenic on the human breast cancer cells. Di(2-ethylhexyl) phthalate (DEHP) showed no estrogenic activity in these in vitro assays. A number of metabolites were tested, including mono-butyl phthalate, mono-benzyl phthalate, mono-ethylhexyl phthalate, mon-n-octyl phthalate; all were wound to be inactive. One of the phthalates, ditridecyl phthalate (DTDP), produced inconsistent results; one sample was weakly estrogenic, whereas another, obtained from a different source, was inactive. analysis by gel chromatography-mass spectometry showed that the preparation exhibiting estrogenic activity contained 0.5% of the ortho-isomer of bisphenol A. It is likely that the presence of this antioxidant in the phthalate standard was responsible for the generation of a dose-response curve--which was not observed with an alternative sample that had not been supplemented with o,p'-bisphenol A--in the yeast screen; hence, DTDP is probably not weakly estrogenic. The activities of simple mixtures of BBP, DBP, and 17beta-estradiol were assessed in the yeast screen. No synergism was observed, although the activities of the mixtures were approximately additive. In summary, a small number of phthalates are weakly estrogenic in vitro. No data has yet been published on whether these are also estrogenic in vitro. No data has yet been published on whether these are also estrogenic in vivo; this will require tests using different classes of vertebrates and different routes of exposure