8 research outputs found
Dilepton production in heavy ion collisions at intermediate energies
We present a unified description of the vector meson and dilepton production
in elementary and in heavy ion reactions. The production of vector mesons
() is described via the excitation of nuclear resonances ().
The theoretical framework is an extended vector meson dominance model (eVMD).
The treatment of the resonance decays with arbitrary spin is
covariant and kinematically complete. The eVMD includes thereby excited vector
meson states in the transition form factors. This ensures correct asymptotics
and provides a unified description of photonic and mesonic decays. The
resonance model is successfully applied to the production in
reactions. The same model is applied to the dilepton production in elementary
reactions (). Corresponding data are well reproduced. However, when
the model is applied to heavy ion reactions in the BEVALAC/SIS energy range the
experimental dilepton spectra measured by the DLS Collaboration are
significantly underestimated at small invariant masses. As a possible solution
of this problem the destruction of quantum interference in a dense medium is
discussed. A decoherent emission through vector mesons decays enhances the
corresponding dilepton yield in heavy ion reactions. In the vicinity of the
-peak the reproduction of the data requires further a substantial
collisional broadening of the and in particular of the meson.Comment: 32 pages revtex, 19 figures, to appear in PR
ТКАНЕВАЯ И КЛЕТОЧНАЯ РЕАКЦИЯ СИНОВИАЛЬНОЙ СРЕДЫ НА ВНУТРИСУСТАВНОЕ ВВЕДЕНИЕ ПОЛИМЕРНОГО ВИСКОПРОТЕЗА «НОЛТРЕКС» В УСЛОВИЯХ ЭКСПЕРИМЕНТА
Reaction of synovial membrane and cartilage on 1 ml of polymer gel «NOLTREX» injected into the cavity of jumping joint of 20 rabbits was investigated. Biological inertness and safety of noltrex injected into the joint cavity was established. Изучена реакция синовиальной оболочки и хряща 20 кроликов на введение 1 мл полимерного геля «Нолтрекс» в полость скакательного сустава. Сделан вывод о биологической инертности и безопасности нолтрекса при его введении в полость сустава
Functional Single-Chain Polymer Nanoparticles: Targeting and Imaging Pancreatic Tumors in Vivo
The development of tools for the early diagnosis of pancreatic adenocarcinoma is an urgent need in order to increase treatment success rate and reduce patient mortality. Here, we present a modular nanosystem platform integrating soft nanoparticles with a targeting peptide and an active imaging agent for diagnostics. Biocompatible single-chain polymer nanoparticles (SCPNs) based on poly(methacrylic acid) were prepared and functionalized with the somatostatin analogue PTR86 as the targeting moiety, since somatostatin receptors are overexpressed in pancreatic cancer. The gamma emitter 67Ga was incorporated by chelation and allowed in vivo investigation of the pharmacokinetic properties of the nanoparticles using single photon emission computerized tomography (SPECT). The resulting engineered nanosystem was tested in a xenograph mouse model of human pancreatic adenocarcinoma. Imaging results demonstrate that accumulation of targeted SCPNs in the tumor is higher than that observed for nontargeted nanoparticles due to improved retention in this tissue. ¸ 2016 American Chemical Society
Functional Single-Chain Polymer Nanoparticles : Targeting and Imaging Pancreatic Tumors in Vivo
The development of tools for the early diagnosis of pancreatic adenocarcinoma is an urgent need in order to increase treatment success rate and reduce patient mortality. Here, we present a modular nanosystem platform integrating soft nanoparticles with a targeting peptide and an active imaging agent for diagnostics. Biocompatible single-chain polymer nanoparticles (SCPNs) based on poly(methacrylic acid) were prepared and functionalized with the somatostatin analogue PTR86 as the targeting moiety, since somatostatin receptors are overexpressed in pancreatic cancer. The gamma emitter 67Ga was incorporated by chelation and allowed in vivo investigation of the pharmacokinetic properties of the nanoparticles using single photon emission computerized tomography (SPECT). The resulting engineered nanosystem was tested in a xenograph mouse model of human pancreatic adenocarcinoma. Imaging results demonstrate that accumulation of targeted SCPNs in the tumor is higher than that observed for nontargeted nanoparticles due to improved retention in this tissue