The Boy from 6B: How Only Murders in the Building Created Groundbreaking Television

Non-disabled actors continue to be cast over disabled actors to portray disabled characters, and disabled storylines are told from an able-bodied perspective. This paper explores how Only Murders in the Building set an example for approaching projects featuring disabled actors and roles while maintaining a complex storyline in the episode titled The Boy from 6B (2021). Analyzing this episode through the lens of the classical idea of anmut shows how it subverted the typical viewing experience of watching a storyline that features disabled characters from an able-bodied perspective. Anmut, as a rhetorical concept, recognizes that the value of physical characteristics is socially constructed; a body can be just as desirable in one cultural setting as it can be undesirable in another. To illustrate this point, anmut creates the space for reconsidering disability by bringing social reactions and underlying assumptions about the human body and physical diversity to the forefront. Only Murders utilized this concept in “The Boy from 6B” by casting a deaf actor to play a deaf character and placing the viewer in the character’s world by removing their sense of hearing and their reliance on sound. The result is a more powerful connection between the viewer and the disabled character. Further, when compared to the movie Music (2020), directed by singer Sia—which features a disabled protagonist—Only Murders stands out by reattributing complexity to a community that is often portrayed reductively and by asking the audience to step, for thirty-one minutes, out of their abled body

Anthropometric Studies: Advanced 3D Method for Taking Anthropometric Data in Albania

ABSTRACT: Anthropometry is the study of human body. Anthropometric data are very useful for designing, as part of the process for developing a design solution in different areas. In the apparel industry, anthropometric data are an important component for producing high quality garments. Garment fit, is one of the main factors in the decision making of the customer. Different countries have undertaken anthropometric studies for updating their sizing systems used for garment design. The last anthropometric study in Albania, has taken place in 1989 with 10 000 persons participated in this study, distributed in 7 regions of the country. Later on in the following years there are taken several studies, but they have been aimed for small target groups. Moving into the full cycle production, by adding more value in the whole production chain of the garment production firms has become a necessity in the last years. There are few firms working with their own brand for the home market, but they use different garment sizing systems. So, it has become a necessity, for Albania companies which operate in garment and footwear industry to use Albanian sizing system. Updating anthropometric data, will help garment and footwear companies ensuring good quality for their products. The scope of this work is showing a methodology for extracting anthropometric data the implementation of advanced 3D technology. A literature review on anthropometric studies conducted in Albania will be introduced in this work

A Major Role for Side-Chain Polyglutamine Hydrogen Bonding in Irreversible Ataxin-3 Aggregation

The protein ataxin-3 consists of an N-terminal globular Josephin domain (JD) and an unstructured C-terminal region containing a stretch of consecutive glutamines that triggers the neurodegenerative disorder spinocerebellar ataxia type 3, when it is expanded beyond a critical threshold. The disease results from misfolding and aggregation, although the pathway and structure of the aggregation intermediates are not fully understood. In order to provide insight into the mechanism of the process, we monitored the aggregation of a normal (AT3Q24) ataxin-3, an expanded (AT3Q55) ataxin-3, and the JD in isolation. We observed that all of them aggregated, although the latter did so at a much slower rate. Furthermore, the expanded AT3Q55 displayed a substantially different behavior with respect to the two other variants in that at the latest stages of the process it was the only one that did the following: i) lost its reactivity towards an anti-oligomer antibody, ii) generated SDS-insoluble aggregates, iii) gave rise to bundles of elongated fibrils, and iv) displayed two additional bands at 1604 and 1656 cm−1 in FTIR spectroscopy. Although these were previously observed in other aggregated polyglutamine proteins, no one has assigned them unambiguously, yet. By H/D exchange experiments we show for the first time that they can be ascribed to glutamine side-chain hydrogen bonding, which is therefore the hallmark of irreversibly SDS-insoluble aggregated protein. FTIR spectra also showed that main-chain intermolecular hydrogen bonding preceded that of glutamine side-chains, which suggests that the former favors the latter by reorganizing backbone geometry

A Major Role for Side-Chain Polyglutamine Hydrogen Bonding in Irreversible Ataxin-3 Aggregation

The protein ataxin-3 consists of an N-terminal globular Josephin domain (JD) and an unstructured C-terminal region containing a stretch of consecutive glutamines that triggers the neurodegenerative disorder spinocerebellar ataxia type 3, when it is expanded beyond a critical threshold. The disease results from misfolding and aggregation, although the pathway and structure of the aggregation intermediates are not fully understood. In order to provide insight into the mechanism of the process, we monitored the aggregation of a normal (AT3Q24) ataxin-3, an expanded (AT3Q55) ataxin-3, and the JD in isolation. We observed that all of them aggregated, although the latter did so at a much slower rate. Furthermore, the expanded AT3Q55 displayed a substantially different behavior with respect to the two other variants in that at the latest stages of the process it was the only one that did the following: i) lost its reactivity towards an anti-oligomer antibody, ii) generated SDS-insoluble aggregates, iii) gave rise to bundles of elongated fibrils, and iv) displayed two additional bands at 1604 and 1656 cm−1 in FTIR spectroscopy. Although these were previously observed in other aggregated polyglutamine proteins, no one has assigned them unambiguously, yet. By H/D exchange experiments we show for the first time that they can be ascribed to glutamine side-chain hydrogen bonding, which is therefore the hallmark of irreversibly SDS-insoluble aggregated protein. FTIR spectra also showed that main-chain intermolecular hydrogen bonding preceded that of glutamine side-chains, which suggests that the former favors the latter by reorganizing backbone geometry

The bending behaviour of linear low density polyethylene monofilaments

Abstract: Linear Low Density Polyethylene (LLDPE) has been successfully used in artificial turf as a pile layer as it meets the initial requirements mentioned in the FIFA Quality Concept for football turf. This paper discusses a critical appraisal of the factors affecting on the bending behaviour of uniaxially oriented monofilaments prepared from LLDPE. The focus is to characterise the bending behaviour by studying it in function of the thickness of the monofilaments and the orientation. The monofilaments of LLDPE were characterized by combining the tensile testing and bending behaviour on dynamic and static bending mode. Beside this monofilaments were characterized for micro-structural details such as amorphous phase orientation, degree of crystallinity and intermediate phase structure. It was found that the relationship between bending behaviour and thickness is very much dependent on the degree of the orientation (DR) of monofilaments. There are remarkable differences between less and high oriented filaments samples

Właściwości charakteryzujące zginanie monofilamentów LLDPE w zależności od stopnia zimnego rozciągu i składu polimeru

The behaviour of the pile layer of artificial turf is an important element for the performance of artificial turf. As a top layer, it is constantly under deformation, with the most possible being bending . The bending behaviour of monofilaments of linear low density polyethylene (LLDPE) is strongly influenced by the processing parameters, the type of polymer, and geometrical factors, which in combination with each other seem to have a strong influence on the behaviour of the final product. From the results obtained, the use of octene instead of hexene as a monomer yields better results for resilience due to a higher concentration of intrafibrillar tie molecules for the same degree of DSC crystallinity of the LLDPEs. The increase in the final cross section of monofilaments based on the same LLPDPEs resulted in a decrease in the intrafibrillar tie molecules due to a slower cooling after melt extrusion.Badania dotyczyły obróbki wykańczalniczej jedwabiu naturalnego. Mikrostruktura jedwabiu była badana za pomocą skaningowej mikroroskopii elektronowej, a właściwości mechaniczne testowane były klasyczną zrywarką firmy Instron, podczas gdy strukturę krystaliczną analizowano za pomocą spektroskopii w podczerwieni (FTIR) oraz rozproszenia promieniowania rentgenowskiego. Wyniki pozwoliły wytypować najlepszą w danych warunkach metodę obróbki

Bending behaviour of LLDPE monofilaments depending on cold drawing and composition of the LLDPEs

The behaviour of the pile layer of artificial turf is an important element for the performance of artificial turf. As a top layer, it is constantly under deformation, with the most possible being bending . The bending behaviour of monofilaments of linear low density polyethylene (LLDPE) is strongly influenced by the processing parameters, the type of polymer, and geometrical factors, which in combination with each other seem to have a strong influence on the behaviour of the final product. From the results obtained, the use of octene instead of hexene as a monomer yields better results for resilience due to a higher concentration of intrafibrillar tie molecules for the same degree of DSC crystallinity of the LLDPEs. The increase in the final cross section of monofilaments based on the same LLPDPEs resulted in a decrease in the intrafibrillar tie molecules due to a slower cooling after melt extrusion