43 research outputs found
Community professionals' management of client care : a mixed-methods systematic review
This is the final draft, after peer-review, of a manuscript published in Journal of Health Services Research & Policy. The definitive version, detailed above, is available online at www.rsmjournals.com.Peer reviewedPostprin
Service users’ first accounts of experiencing endings from a psychological service or therapy: a systematic review and meta-ethnographic synthesis
Purpose: To review and synthesis the qualitative literature on service users’ experiences of endings from a psychological service or therapy. Methods: A systematic search of the peer-reviewed literature was conducted. Studies were identified using specific inclusion criteria and included in the synthesis. A modified CASP tool was used to critically appraise the quality of the papers. A meta-ethnographic approach was used to synthesize the findings from the included studies. Results: Twelve papers were identified which met the inclusion criteria. The interpretation of findings suggested three key themes: anticipation of ending, service user control and sense of responsibility. Studies were geographically spread and of high quality. Conclusions: The review highlights the importance of service users’ perspectives in understanding the experiences of endings. The findings complement existing literature and provide new interpretations. Considerations for practice in the UK were limited however the review does provide directions for future research
Working with the complexities of adolescent mental health problems: applying time-limited adolescent psychodynamic psychotherapy (TAPP)
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Exome and whole genome sequencing of esophageal adenocarcinoma identifies recurrent driver events and mutational complexity
The incidence of esophageal adenocarcinoma (EAC) has risen 600% over the last 30 years. With a five-year survival rate of 15%, identification of new therapeutic targets for EAC is greatly important. We analyze the mutation spectra from whole exome sequencing of 149 EAC tumors/normal pairs, 15 of which have also been subjected to whole genome sequencing. We identify a mutational signature defined by a high prevalence of A to C transversions at AA dinucleotides. Statistical analysis of exome data identified significantly mutated 26 genes. Of these genes, four (TP53, CDKN2A, SMAD4, and PIK3CA) have been previously implicated in EAC. The novel significantly mutated genes include chromatin modifying factors and candidate contributors: SPG20, TLR4, ELMO1, and DOCK2. Functional analyses of EAC-derived mutations in ELMO1 reveal increased cellular invasion. Therefore, we suggest a new hypothesis about the potential activation of the RAC1 pathway to be a contributor to EAC tumorigenesis
Medulloblastoma Exome Sequencing Uncovers Subtype-Specific Somatic Mutations
Medulloblastomas are the most common malignant brain tumors in children1. Identifying and understanding the genetic events that drive these tumors is critical for the development of more effective diagnostic, prognostic and therapeutic strategies. Recently, our group and others described distinct molecular subtypes of medulloblastoma based on transcriptional and copy number profiles2–5. Here, we utilized whole exome hybrid capture and deep sequencing to identify somatic mutations across the coding regions of 92 primary medulloblastoma/normal pairs. Overall, medulloblastomas exhibit low mutation rates consistent with other pediatric tumors, with a median of 0.35 non-silent mutations per megabase. We identified twelve genes mutated at statistically significant frequencies, including previously known mutated genes in medulloblastoma such as CTNNB1, PTCH1, MLL2, SMARCA4 and TP53. Recurrent somatic mutations were identified in an RNA helicase gene, DDX3X, often concurrent with CTNNB1 mutations, and in the nuclear co-repressor (N-CoR) complex genes GPS2, BCOR, and LDB1, novel findings in medulloblastoma. We show that mutant DDX3X potentiates transactivation of a TCF promoter and enhances cell viability in combination with mutant but not wild type beta-catenin. Together, our study reveals the alteration of Wnt, Hedgehog, histone methyltransferase and now N-CoR pathways across medulloblastomas and within specific subtypes of this disease, and nominates the RNA helicase DDX3X as a component of pathogenic beta-catenin signaling in medulloblastoma
Some observations on the fish nurseries along the lake Kinneret shores: the interrelationships between species, and the influence of environmental factors
Estimation of Stellar Metal Abundance. II : A Recalibration of the Ca II K Technique, and the Autocorrelation Function Method
Original article can be found at: http://www.iop.org/EJ/journal/aj Copyright American Astronomical Society DOI: 10.1086/300727 [Full text of this article is not available in the UHRA]We have recalibrated a method for the estimation of stellar metal abundance, parameterized as [Fe/H], based on medium-resolution (1–2 Å) optical spectra (the majority of which cover the wavelength range 3700–4500 Å). The equivalent width of the Ca II K line (3933 Å) as a function of [Fe/H] and broadband B-V color, as predicted from spectrum synthesis and model atmosphere calculations, is compared with observations of 551 stars with high-resolution abundances available from the literature (a sevenfold increase in the number of calibration stars that were previously available). A second method, based on the Fourier autocorrelation function technique first described by Ratnatunga & Freeman, is used to provide an independent estimate of [Fe/H], as calibrated by comparison with 405 standard-star abundances. Metallicities based on a combination of the two techniques for dwarfs and giants in the color range 0.30 ≤ (B-V)0 ≤ 1.2 exhibit an external 1 σ scatter of approximately 0.10–0.20 dex over the abundance range -4.0 ≤ [Fe/H] ≤ 0.5. Particular attention has been given to the determination of abundance estimates at the metal-rich end of the calibration, where our previous attempt suffered from a considerable zero-point offset. Radial velocities, accurate to approximately 10 km s-1, are reported for all 551 calibration stars.Peer reviewe