3,024 research outputs found
Pharmacokinetics and efficacy of oral versus intravenous mixed-micellar phylloquinone (vitamin K-1) in severe acute liver disease
Background/Aims: In patients with severe acute liver dysfunction, i.v. phylloquinone (vitamin K-1) may be given to exclude vitamin K deficiency, rather than impaired hepatic synthesis of coagulation factors alone, as the cause of the coagulopathy. However, there have been no studies of the pharmacokinetics or efficacy of i.v. or oral K-1 in such patients.Methods: 49 adults with severe acute liver disease were randomised double-blind to a single 10 mg dose of i.v. or oral mixed-micellar K-1, or placebo. Serum levels of phylloquinone and undercarboxylated prothrombin (PIVKA-II) were assessed before and after treatment.Results: At admission, 13 patients (27 %) had either low serum K-1 levels or elevated PIVKA-II concentrations, indicative of subclinical vitamin K deficiency. In the 16 patients who received i.v. K-1, there was one (6 %) treatment failure (K-1 rise < 10 ng/ml above baseline), compared with 12 of the 15 (80 %) who received oral K, (P < 0.0001). One patient in the placebo group developed overt vitamin K deficiency.Conclusions: A minority of patients with severe acute liver dysfunction have subclinical vitamin K deficiency at the time of presentation, which is corrected by a single dose of i.v. K-1. The intestinal absorption of mixed-micellar K, is unreliable in adults with severe acute liver dysfunction. (c) 2004 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved
Unpulsed UBV Optical Emission from the Crab Pulsar
Based on observations of the Crab pulsar using the TRIFFID high speed imaging
photometer in the UBV bands using the Special Astrophysical Observatory's 6m
telescope in the Russian Caucasus, we report the detection of pronounced
emission during the so-called `off' phase of emission. Following de-extinction,
this unpulsed component of emission is shown to be consistent with a power law
with an exponent of alpha = -0.60 +/- 0.37, the uncertainty being dominated by
the error associated with the independent CCD photometry used to reference the
TRIFFID data. This suggests a steeper power law form than that reported
elsewhere in the literature for the total integrated spectrum, which is
essentially flat with alpha ~ 0.1, although the difference in this case is only
significant at the ~ 2 sigma level. Deeper reference integrated and TRIFFID
phase-resolved photometry in these bands in conjunction with further
observations in the UV and R region would constrain this fit further.Comment: 26 pages, 2 figures, uses aasms4.sty, accepted for publication in the
Astrophysical Journa
The Expression and Roles of Nde1 and Ndel1 in the Adult Mammalian Central Nervous System
Open Access funded by Wellcome Trust Under a Creative Commons license Acknowledgments We thank Prof Angelo Sementilli, Department of Pathology, Universidade Metropolitana de Santos, SP, Brazil, for the human sample collection. This study is funded by Scottish Universities Life Sciences Alliance (HR07019 to S. Shen and C.D. McCaig), Medical Research Scotland (384 FRG to B. Lang, United Kingdom), Tenovus Scotland (G12/25 to B. Lang), Sino-UK Higher Education Research Partnership for PhD Studies (C.D. McCaig and Y.Q. Ding) and Wellcome Trust (WT081633MA-NCE to P.J.A. McCaffery, United Kingdom).Peer reviewedPublisher PD
Production of a high-density state-selected metastable neon beam
We have developed a high-density source of metastable neon and have selectively quenched both metastable species using a standing-wave dye laser. The source is compact, stable, and produces an average intensity of 3.6 x 1014 sr -1 s -1 and a density on target of 7.7 x 106 cm-3
Production of a high-density state-selected metastable neon beam
We have developed a high-density source of metastable neon and have selectively quenched both metastable species using a standing-wave dye laser. The source is compact, stable, and produces an average intensity of 3.6 x 1014 sr -1 s -1 and a density on target of 7.7 x 106 cm-3
A Dialectical Basis for Software Development Tool Building
We identify typical problems in the interactions of people with current software-based systems. In particular we observe the need to expend significant on-going effort to adapt these systems to reflect changes in the world about them, the need for people to adapt their working practices to fit in with these systems, and the inflexibility of these systems when faced with unusual circumstances or the need for change. We believe that these problems follow, at least in part, from these systems being developed and evolved using mechanisms each based on one Inquiry System only. This basis leads to assumptions being embedded in the mechanisms’ analysis outputs, and in system designs and implementations. We suggest that the problems noted may be mitigated by the use of a dialectical approach to Inquiry System selection for software development, based on the work of Hegel, which places in opposition different models of a situation based on different Inquiry Systems. We claim that such a mechanism has the potential to make explicit some of the assumptions which would otherwise be embedded implicitly in the delivered system without being questioned. We outline a research programme intended to test this hypothesis, and suggest other research directions
Variations in solar wind fractionation as seen by ACE/SWICS over a solar cycle and the implications for Genesis Mission results
We use ACE/SWICS elemental composition data to compare the variations in
solar wind fractionation as measured by SWICS during the last solar maximum
(1999-2001), the solar minimum (2006-2009) and the period in which the Genesis
spacecraft was collecting solar wind (late 2001 - early 2004). We differentiate
our analysis in terms of solar wind regimes (i.e. originating from interstream
or coronal hole flows, or coronal mass ejecta). Abundances are normalized to
the low-FIP ion magnesium to uncover correlations that are not apparent when
normalizing to high-FIP ions. We find that relative to magnesium, the other
low-FIP elements are measurably fractionated, but the degree of fractionation
does not vary significantly over the solar cycle. For the high-FIP ions,
variation in fractionation over the solar cycle is significant: greatest for
Ne/Mg and C/Mg, less so for O/Mg, and the least for He/Mg. When abundance
ratios are examined as a function of solar wind speed, we find a strong
correlation, with the remarkable observation that the degree of fractionation
follows a mass-dependent trend. We discuss the implications for correcting the
Genesis sample return results to photospheric abundances.Comment: Accepted for publication in Ap
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