Mean rotor wake characteristics of an aerodynamically loaded 0.5 m diameter fan

Mean rotor wake properties at several downstream distances behind the rotor of a loaded 1.2 pressure ratio fan were measured with a cross film anemometer in an anechoic wind tunnel. Mean wake characteristics in the midspan and near tip region were determined utilizing an ensemble averaging technique. The upwash and streamwise components of the velocity behind the rotor indicate a complex structure superimposed on the major velocity defects at a down stream spacing of 0.5 rotor chords. Spectral analysis indicates high levels of the second and fourth harmonics of the blade passage frequency in the midspan region while the blade passage frequency and its second and third harmonic are predominant in the tip region

Laser Interferometer Gravitational-Wave Observatory beam tube component and module leak testing

Laser Interferometer Gravitational-Wave Observatory (LIGO) is a joint project of the California Institute of Technology and the Massachusetts Institute of Technology funded by the National Science Foundation. The project is designed to detect gravitational waves from astrophysical sources such as supernova and black holes. The LIGO project constructed observatories at two sites in the U.S. Each site includes two beam tubes (each 4 km long) joined to form an "L" shape. The beam tube is a 1.25 m diam 304 L stainless steel, ultrahigh vacuum tube that will operate at 1×10^–9 Torr or better. The beam tube was manufactured using a custom spiral weld tube mill from material processed to reduce the outgassing rate in order to minimize pumping costs. The integrity of the beam tube was assured by helium mass spectrometer leak testing each component of the beam tube system prior to installation. Each 2 km long, isolatable beam tube module was then leak tested after completion

The presence of valine at residue 129 in human prion protein accelerates amyloid formation

The polymorphism at residue 129 of the human PRNP gene modulates disease susceptibility and the clinicopathological phenotypes in human transmissible spongiform encephalopathies. The molecular mechanisms by which the effect of this polymorphism are mediated remain unclear. It has been shown that the folding, dynamics and stability of the physiological, alpha-helix-rich form of recombinant PrP are not affected by codon 129 polymorphism. Consistent with this, we have recently shown that the kinetics of amyloid formation do not differ between protein containing methionine at codon 129 and valine at codon 129 when the reaction is initiated from the a-monomeric PrPC-like state. In contrast, we have shown that the misfolding pathway leading to the formation of beta-sheet-rich, soluble oligomer waS favoured by the presence of methionine, compared with valine, at position 129. In the present work, we examine the effect of this polymorphism on the kinetics of an alternative misfolding pathway, that of amyloid formation using partially folded PrP allelomorphs. We show that the valine 129 allelomorph forms amyloids with a considerably shorter lag phase than the methionine 129 allelomorph both under spontaneous conditions and when seeded with pre-formed amyloid fibres. Taken together, our studies demonstrate that the effect of the codon 129 polymorphism depends on the specific misfolding pathway and on the initial conformation of the protein. The inverse propensities of the two allelomorphs to misfold in vitro through the alternative oligomeric and amyloidogenic pathways could explain some aspects of prion diseases linked to this polymorphism such as age at onset and disease incubation time. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved

The constrained modified KP hierarchy and the generalized Miura transformations

In this letter, we consider the second Hamiltonian structure of the constrained modified KP hierarchy. After mapping the Lax operator to a pure differential operator the second structure becomes the sum of the second and the third Gelfand-Dickey brackets defined by this differential operator. We simplify this Hamiltonian structure by factorizing the Lax operator into linear terms.Comment: 8 pages, latex, no figure

X-ray emission mechanisms in accreting white dwarfs

In this chapter we consider the processes which can lead to X-ray emission from different types of cataclysmic variable stars (CVs). CVs are semi-detached, binary star systems where material is transferred from the donor star (also known as the companion or secondary star) onto the white dwarf primary. CVs are divided into several sub-classes based on the observed phenomenology in the optical and X-ray bands, which, in turn, is largely defined by the magnetic field strength of the accretor. In non-magnetic systems, a variety of observed behaviours are identified, depending on the accretion rate: novae, dwarf novae, nova-like variables, symbiotic binaries and supersoft sources are all examples of non-magnetic CVs. In magnetic systems (polars and intermediate polars, or AM Her and DQ Her systems, respectively), the accretion flow is channelled to polar regions, and the observational appearance is different. X-rays are typically produced through hot or energetic processes, and in CVs they are formed via shocks (within a boundary layer or accretion column, or through interactions either internal to the nova ejecta, or between the ejecta and a stellar wind) or from hydrogen burning (either steady fusion, or a thermonuclear runaway). All of these different types of accreting white dwarfs are discussed here, considering both spectral and temporal variability in the different populations.Comment: 48 pages (though pages 36 onwards consist entirely of references, due to a poorly designed style file!), 15 figures. Invited (and accepted) chapter for the Handbook of X-ray and Gamma-ray Astrophysic

Near-infrared counterparts of three transient very faint neutron star X-ray binaries

We present near-infrared (NIR) imaging observations of three transient neutron star X-ray binaries, SAX J1753.5-2349, SAX J1806.5-2215 and AX J1754.2-2754. All three sources are members of the class of `very faint' X-ray transients which exhibit X-ray luminosities $L_X\lesssim10^{36}$ erg s$^{-1}$. The nature of this class of sources is still poorly understood. We detect NIR counterparts for all three systems and perform multi-band photometry for both SAX J1753.5-2349 and SAX J1806.5-2215, including narrow-band Br$_{\gamma}$ photometry for SAX J1806.5-2215. We find that SAX J1753.5-2349 is significantly redder than the field population, indicating that there may be absorption intrinsic to the system, or perhaps a jet is contributing to the infrared emission. SAX J1806.5-2215 appears to exhibit absorption in Br$_{\gamma}$, providing evidence for hydrogen in the system. Our observations of AX J1754.2--2754 represent the first detection of a NIR counterpart for this system. We find that none of the measured magnitudes are consistent with the expected quiescent magnitudes of these systems. Assuming that the infrared radiation is dominated by either the disc or the companion star, the observed magnitudes argue against an ultracompact nature for all three systems.Comment: 10 pages, 10 figures, accepted for publication in MNRA

The paracrinology of tubal ectopic pregnancy

As part of successful human reproduction, the Fallopian tube must provide a suitable environment for pre-implantation development of the embryo and for efficient transport of the embryo to the uterus for implantation. These functions are coordinated by paracrine interactions between tubal epithelial, smooth muscle and immune cells and the cells of the developing embryo. Alterations in these signals can lead to a tubal microenvironment encouraging of embryo implantation and to dysregulated tubal motility, ultimately resulting in inappropriate and early implantation of the embryo in the Fallopian tube. Here, we highlight novel and emerging concepts in tubal physiology and pathobiology, such as the induction of a receptive phenotype within the Fallopian tube, leading to ectopic implantation. Chlamydia trachomatis infection is a risk factor for tubal ectopic pregnancy. Activation of toll-like receptor 2 (TLR-2) in the Fallopian tube epithelium, by C. trachomatis has recently been demonstrated, leading to the dysregulation of factors involved in implantation and smooth muscle contractility, such as prokineticins (PROK), activin A and interleukin 1 (IL-1). The Fallopian tube has also recently been shown to harbour a unique population of immune cells, compared to the endometrium. In addition, the complement of immune cells in the Fallopian tube has been reported to be altered in Fallopian tube from women with ectopic pregnancy. There are increasing data suggesting that vascularisation of the Fallopian tube, by the embryo during ectopic pregnancy, differs from that initiated in the uterus during normal pregnancy. This too, is likely the result of paracrine signals between the embryo and the tubal microenvironment

(Super)twistors and (super)strings

The Lagrangian formulation of the D=4 bosonic string and superstring in terms of the (super)twistors is considered. The (super)twistor form of the equations of motion is derived and the kappa-symmetry transformation for the supertwistors is given. It is shown that the covariant kappa-symmetry gauge fixation results in the action quadratic in the (super)twistor variables.Comment: LaTeX, 17 page

Counselor Lesbian, Gay, and Bisexual Competency: Christian and Non-Religious Addiction Counseling Programs

This study compared levels of professional competency working with self-identified lesbian, gay, and bisexual (LGB) clients among graduates and field experience students of Christian and nonreligious-affiliated CACREP-accredited addiction counseling programs. Applicants completed an instrument to measure the dependent variables of awareness, knowledge, and skills to work with LGB clients. The sample consisted of 84 master’s students in field experience and unlicensed counselors within 2 years of graduation. Multivariate analysis of variance was used to test the hypotheses. Participants from nonreligious-affiliated addiction counseling programs scored higher on the awareness (M = 68.82, M = 63.03), knowledge (M = 50.22, M = 35.88), and skills (M = 43.20, M = 37.91) subscales than participants from Christian-affiliated programs. These differences were found to be statistically significant at p \u3c .000