346 research outputs found
Economic Reform and Integration. Proceedings of 1-3 March 1990 Meeting
The general aim of the IIASA Project on "Economic Reform and Integration" (ERI) can be formulated as establishing bridges between eastern and western economic theory and practice, creating conditions for mutually assimilating successful managerial experience, and for possible rapprochement of economic systems.
This volume contains major contributions by Soviet scientists, together with comments by western experts offered during the 1-3 March 1990 ERI Meeting. We believe that this material is of wide and timely interest and may also serve as a reference document for later studies once the time has come to penetrate scientifically the very fast changes we are witnessing today in central and eastern Europe
Sentinel-2 water indexes application for the underground water level analyses in Ovidiopol area of Odessa region
Studied area has a high level of agricultural development. There are different irrigation and drainage systems located there. Significant part of the supplied water losses from the irrigation network because of filtration and reaches the groundwater level, which begins to rise. Control and analyses of groundwater level changes with remote sensing methods for Ovidiopol area is the main goal of that work. The object of study is the groundwater level regime in the territory of Lower Dniester irrigation system in Ovidiopol district, Odessa region. The subject of research is water indexes application for analyses of groundwater level changes. The local system of groundwater observation includes 7 drillholes in Nadlimanskoe village and around. These drillholes located in different geomorphological, hydrogeological and technogenic conditions. The groundwater level was surveyed monthly in 2017. Sentinel-2 2A images for each month from March 2017 to December 2017 were used for studied area. All satellite images has atmospheric correction. Three water indexes NDWI, MNDWI, NDPI were calculated for drillhole points for each month in 2017 year. Significant correlation coefficients obtained in comparison between groundwater level changes and water indexes in some drillholes points. The highest numbers of correlation connected with free of construction areas and for drillholes, which are located outside of villages
Monitoring of gene knockouts: genome-wide profiling of conditionally essential genes
Monitoring of gene knockouts is a new microarray-based genetic technique used for genome-wide identification of conditionally essential genes in bacteri
H2S, a Bacterial Defense Mechanism against the Host Immune Response
The biological mediator hydrogen sulfide (H2S) is produced by bacteria and has been shown to be cytoprotective against oxidative stress and to increase the sensitivity of various bacteria to a range of antibiotic drugs. Here we evaluated whether bacterial H2S provides resistance against the immune response, using two bacterial species that are common sources of nosocomial infections, Escherichia coli and Staphylococcus aureus. Elevations in H2S levels increased the resistance of both species to immune-mediated killing. Clearances of infections with wild-type and genetically H2S-deficient E. coli and S. aureus were compared in vitro and in mouse models of abdominal sepsis and burn wound infection. Also, inhibitors of H2S- producing enzymes were used to assess bacterial killing by leukocytes. We found that inhibition of bacterial H2S production can increase the susceptibility of both bacterial species to rapid killing by immune cells and can improve bacterial clearance after severe burn, an injury that increases susceptibility to opportunistic infections. These findings support the role of H2S as a bacterial defense mechanism against the host response and implicate bacterial H2S inhibition as a potential therapeutic intervention in the prevention or treatment of infections
Π ΠΎΠ»Ρ Π°ΠΊΡΠΈΠ²Π½ΠΈΡ ΡΠΎΡΠΌ ΠΊΠΈΡΠ½Ρ ΡΠ° Π°Π·ΠΎΡΡ Π² ΠΌΠ΅Ρ Π°Π½ΡΠ·ΠΌΠ°Ρ ΡΡΠΊΠΎΠ΄ΠΆΠ΅Π½Π½Ρ ΡΡΠΌβΡΠ½ΠΈΠΊΡΠ² Ρ ΡΠΏΠ΅ΡΠΌΠ°ΡΠΎΠ·ΠΎΡΠ΄ΡΠ² ΠΏΡΠΈ ΠΏΠΎΡΠ΄Π½Π°Π½ΡΠΉ Π΄ΡΡ Π½Π° ΠΎΡΠ³Π°Π½ΡΠ·ΠΌ ΡΠ΅Π½ΡΠ³Π΅Π½ΡΠ²ΡΡΠΊΠΎΠ³ΠΎ ΠΎΠΏΡΠΎΠΌΡΠ½Π΅Π½Π½Ρ ΡΠ° Π½ΡΡΡΠ°ΡΡ Π½Π°ΡΡΡΡ
Π ΡΠΎΠ±ΠΎΡΡ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΎΡΡΠ½ΠΊΠ° ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡΠ² Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΠΈΡ
Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Ρ ΠΏΠΎΡΠ΄Π½Π°Π½ΠΎΡ Π΄ΡΡ Π½Π° ΠΎΡΠ³Π°Π½ΡΠ·ΠΌ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΈΡ
ΡΡΡΡΠ² ΡΠ΅Π½ΡΠ³Π΅Π½ΡΠ²ΡΡΠΊΠΎΠ³ΠΎ ΠΎΠΏΡΠΎΠΌΡΠ½Π΅Π½Π½Ρ ΡΠ° Π½ΡΡΡΠ°ΡΡ Π½Π°ΡΡΡΡ Π·Π° ΠΏΠΎΠΊΠ°Π·Π½ΠΈΠΊΠ°ΠΌΠΈ ΡΠΎΠ·Π²ΠΈΡΠΊΡ ΠΎΠΊΠΈΡΠ½ΠΎ-Π½ΡΡΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΡΡΠ΅ΡΡ Π² ΡΡΠΌβΡΠ½ΠΈΠΊΠ°Ρ
ΡΠ° ΡΠΏΠ΅ΡΠΌΡ.
ΠΠ° ΠΎΡΠ½ΠΎΠ²Ρ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ
Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Ρ Π²ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ ΠΎΡΠΎΠ±Π»ΠΈΠ²ΠΎΡΡΡ ΠΏΠΎΡΠ΄Π½Π°Π½ΠΎΡ Π΄ΡΡ Π½Π° ΠΎΡΠ³Π°Π½ΡΠ·ΠΌ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΠΈΡ
ΡΡΡΡΠ² ΡΡΠ°ΠΊΡΡΠΉΠ½ΠΎΠ³ΠΎ ΡΠ΅Π½ΡΠ³Π΅Π½ΡΠ²ΡΡΠΊΠΎΠ³ΠΎ ΠΎΠΏΡΠΎΠΌΡΠ½Π΅Π½Π½Ρ Π² ΡΡΠΌΠ°ΡΠ½ΡΠΉ Π΄ΠΎΠ·Ρ 0,24 ΠΡ ΡΠ° Π½ΡΡΡΠ°ΡΡ Π½Π°ΡΡΡΡ, ΡΠΎ Π²ΠΈΡΠ°ΠΆΠ°ΡΡΡΡΡ Π² ΡΠΎΠ·Π²ΠΈΡΠΊΡ Π½Π΅Π³Π°ΡΠΈΠ²Π½ΠΈΡ
Π΅ΡΠ΅ΠΊΡΡΠ² Ρ ΡΡΠΌβΡΠ½ΠΈΠΊΠ°Ρ
ΡΡΠ²ΠΎΡΠ΅Π½Π½Ρ ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ½ΡΡΡΠΈΡΡ, ΡΠΎΠ·Π²ΠΈΡΠΊΡ Π΄Π΅ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠΎΠ²Π°Π½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ½Π΅Π½Π½Ρ Π»ΡΠΏΡΠ΄ΡΠ², Π·ΠΌΠ΅Π½ΡΠ΅Π½Π½Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠΈΡΠΎΡ
ΡΠΎΠΌΠΎΠΊΡΠΈΠ΄Π°Π·ΠΈ) ΡΠ° ΡΠΏΠ΅ΡΠΌΠ°ΡΠΎΠ·ΠΎΡΠ΄Π°Ρ
ΡΡΡΡΠ² (Π·Π±ΡΠ»ΡΡΠ΅Π½Π½Ρ Π³ΡΠΏΠ΅ΡΠΏΡΠΎΠ΄ΡΠΊΡΡΡ ΡΡΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π½ΠΎΠ³ΠΎ Π°Π½ΡΠΎΠ½-ΡΠ°Π΄ΠΈΠΊΠ°Π»Π° ΠΌΡΡΠΎΡ
ΠΎΠ½Π΄ΡΡΠ°Π»ΡΠ½ΠΈΠΌ Π΅Π»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎ-ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΠΈΠΌ Π»Π°Π½ΡΡΠ³ΠΎΠΌ, ΡΡΠΌΠ°ΡΠ½ΠΎΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ NO-ΡΠΈΠ½ΡΠ°Π· ΡΠ° ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ½Π΅Π½Π½Ρ Π»ΡΠΏΡΠ΄ΡΠ².
ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΠΎ Π²Π²Π΅Π΄Π΅Π½Π½Ρ ΠΌΠ΅Π»Π°ΡΠΎΠ½ΡΠ½Ρ ΡΠ° ΡΠ½Π³ΡΠ±ΡΡΠΎΡΠ° Π°ΠΊΡΠΈΠ²Π°ΡΡΡ ΡΠ΄Π΅ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΠΊΡΠΎΡΠ° ΞΊB (NF-ΞΊB) JSH-23 Π·Π° ΡΠΌΠΎΠ² Π΅ΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΡ ΠΎΠ±ΠΌΠ΅ΠΆΡΡ Ρ ΡΠΊΠ°Π½ΠΈΠ½Π°Ρ
ΡΡΠΌβΡΠ½ΠΈΠΊΡΠ² Π³Π΅Π½Π΅ΡΠ°ΡΡΡ ΡΡΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π½ΠΎΠ³ΠΎ Π°Π½ΡΠΎΠ½-ΡΠ°Π΄ΠΈΠΊΠ°Π»Π° Π΄ΠΈΡ
Π°Π»ΡΠ½ΠΈΠΌ Π»Π°Π½ΡΡΠ³ΠΎΠΌ ΠΌΡΡΠΎΡ
ΠΎΠ½Π΄ΡΡΠΉ, Π·ΠΌΠ΅Π½ΡΡΡ ΡΡΠΌΠ°ΡΠ½Ρ Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ NO-ΡΠΈΠ½ΡΠ°Π·, ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΡΡ Π½ΡΡΡΠΈΡ-ΠΉΠΎΠ½ΡΠ² Ρ ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ½ΡΡΡΠΈΡΡ, ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π½Π΅ ΠΎΠΊΠΈΡΠ½Π΅Π½Π½Ρ Π»ΡΠΏΡΠ΄ΡΠ², ΠΏΡΠ΄Π²ΠΈΡΡΡ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΠΈΠΉ ΠΏΠΎΡΠ΅Π½ΡΡΠ°Π» ΡΠ° Π°ΠΊΡΠΈΠ²Π½ΡΡΡΡ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΠΈΡ
ΡΠ΅ΡΠΌΠ΅Π½ΡΡΠ² β ΡΡΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π΄ΠΈΡΠΌΡΡΠ°Π·ΠΈ ΡΠ° ΠΊΠ°ΡΠ°Π»Π°Π·ΠΈ.
ΠΡΠΎΠ²Π΅Π΄Π΅Π½Ρ Π΄ΠΎΡΠ»ΡΠ΄ΠΆΠ΅Π½Π½Ρ Π΄ΠΎΠ·Π²ΠΎΠ»ΡΡΡΡ Π²Π²Π°ΠΆΠ°ΡΠΈ Π·Π° Π΄ΠΎΡΡΠ»ΡΠ½Π΅ ΠΏΠΎΠ΄Π°Π»ΡΡΠ΅ Π²ΠΈΠ²ΡΠ΅Π½Π½Ρ Π²ΠΏΠ»ΠΈΠ²Ρ ΠΌΠ΅Π»Π°ΡΠΎΠ½ΡΠ½Ρ ΡΠ° ΡΠ½Π³ΡΠ±ΡΡΠΎΡΡΠ² Π°ΠΊΡΠΈΠ²Π°ΡΡΡ NF-ΞΊB ΡΠΊ ΠΏΠΎΡΠ΅Π½ΡΡΠΉΠ½ΠΈΡ
Π³ΠΎΠ½Π°Π΄ΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΡΠ² Ρ ΡΠΎΠ»ΠΎΠ²ΡΠΊΡΠ², ΡΠΊΡ Π·Π°Π·Π½Π°ΡΡΡ Π²ΠΏΠ»ΠΈΠ²Ρ ΡΠΎΠ½ΡΠ·ΡΡΡΠΎΠ³ΠΎ ΠΎΠΏΡΠΎΠΌΡΠ½Π΅Π½Π½Ρ ΡΠ° Π΄ΡΡ ΡΠΎΠΊΡΠΈΡΠ½ΠΈΡ
ΡΠΈΠ½Π½ΠΈΠΊΡΠ².Π ΡΠ°Π±ΠΎΡΠ΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΎΡΠ΅Π½ΠΊΠ° ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ°Π»ΡΠ½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π½Π° ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΊΡΡΡ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ²ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΡ ΠΈ Π½ΠΈΡΡΠ°ΡΠ° Π½Π°ΡΡΠΈΡ ΠΏΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΎΠΊΠΈΡΠ»ΠΈΡΠ΅Π»ΡΠ½ΠΎ-Π½ΠΈΡΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΡΡΡΠ΅ΡΡΠ° Π² ΡΠ΅ΠΌΠ΅Π½Π½ΠΈΠΊΠ°Ρ
ΠΈ ΡΠΏΠ΅ΡΠΌΠ΅. ΠΠ° ΠΎΡΠ½ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π½Π° ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
ΠΊΡΡΡ ΡΡΠ°ΠΊΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ²ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΡ Π² ΡΡΠΌΠΌΠ°ΡΠ½ΠΎΠΉ Π΄ΠΎΠ·Π΅ 0,24 ΠΡ ΠΈ Π½ΠΈΡΡΠ°ΡΠ° Π½Π°ΡΡΠΈΡ, ΡΡΠΎ Π²ΡΡΠ°ΠΆΠ°Π΅ΡΡΡ Π² ΡΠ°Π·Π²ΠΈΡΠΈΠΈ Π½Π΅Π³Π°ΡΠΈΠ²Π½ΡΡ
ΡΡΡΠ΅ΠΊΡΠΎΠ² Π² ΡΠ΅ΠΌΠ΅Π½Π½ΠΈΠΊΠ°Ρ
- ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠΈ ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ½ΠΈΡΡΠΈΡΠ°, ΡΠ°Π·Π²ΠΈΡΠΈΠΈ Π½Π΅ΠΊΠΎΠΌΠΏΠ΅Π½ΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ², ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠΈ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΠΈΡΠΎΡ
ΡΠΎΠΌΠΎΠΊΡΠΈΠ΄Π°Π·Ρ) ΠΈ ΡΠΏΠ΅ΡΠΌΠ°ΡΠΎΠ·ΠΎΠΈΠ΄Π°Ρ
ΠΊΡΡΡ (ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠΈ Π³ΠΈΠΏΠ΅ΡΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ ΡΡΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π½ΠΎΠ³ΠΎ Π°Π½ΠΈΠΎΠ½-ΡΠ°Π΄ΠΈΠΊΠ°Π»Π° ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎ-ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΠΎΠΉ ΡΠ΅ΠΏΡΡ, ΡΡΠΌΠΌΠ°ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ NO-ΡΠΈΠ½ΡΠ°Π· ΠΈ ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ².
ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΌΠ΅Π»Π°ΡΠΎΠ½ΠΈΠ½Π° Π² Π΄ΠΎΠ·Π΅ 0,3 ΠΌΠ³/ΠΊΠ³ ΠΌΠ°ΡΡΡ ΡΠ΅Π»Π° Π² ΡΠ΅ΡΠ΅Π½ΠΈΠΈ 30 ΡΡΡΠΎΠΊ ΠΏΡΠΈ ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠ°Π΄ΠΈΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΈ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΠΎΠ³ΡΠ°Π½ΠΈΡΠΈΠ²Π°Π΅Ρ Π³Π΅Π½Π΅ΡΠ°ΡΠΈΡ ΡΡΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π½ΠΎΠ³ΠΎ Π°Π½ΠΈΠΎΠ½-ΡΠ°Π΄ΠΈΠΊΠ°Π»Π° Π² ΡΠΊΠ°Π½ΡΡ
ΡΠ΅ΠΌΠ΅Π½Π½ΠΈΠΊΠΎΠ² Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠ΅ΠΏΡΡ ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠΉ, ΠΏΠΎΠ²ΡΡΠ°Π΅Ρ Π² Π½ΠΈΡ
Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠΈΡΠΎΡ
ΡΠΎΠΌΠΎΠΊΡΠΈΠ΄Π°Π·Ρ, ΡΠΌΠ΅Π½ΡΡΠ°Π΅Ρ ΡΡΠΌΠΌΠ°ΡΠ½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ NO-ΡΠΈΠ½ΡΠ°Π·, ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ Π½ΠΈΡΡΠΈΡ-ΠΈΠΎΠ½ΠΎΠ² ΠΈ ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ½ΠΈΡΡΠΈΡΠ°, ΡΡΠΎ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΡΡΡ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ Π²ΡΠΎΡΠΈΡΠ½ΡΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ², ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ΠΌ Π² Π½ΠΈΡ
Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΡΡ
ΡΠ΅ΡΠΌΠ΅Π½ΡΠΎΠ² β ΡΡΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π΄ΠΈΡΠΌΡΡΠ°Π·Ρ, ΠΊΠ°ΡΠ°Π»Π°Π·Ρ, Π³Π»ΡΡΠ°ΡΠΈΠΎΠ½ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π°Π·Ρ. Π ΡΠΏΠ΅ΡΠΌΠ΅ ΠΎΠ³ΡΠ°Π½ΠΈΡΠΈΠ²Π°Π΅ΡΡΡ Π³Π΅Π½Π΅ΡΠ°ΡΠΈΡ ΡΡΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π½ΠΎΠ³ΠΎ Π°Π½ΠΈΠΎΠ½-ΡΠ°Π΄ΠΈΠΊΠ°Π»Π° ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΡΠΌ ΠΈ ΠΠΠΠ€Π-ΡΠΈΡΠΎΡ
ΡΠΎΠΌ Π 450 ΠΈ ΠΠΠΠ€Π-ΡΠΈΡΠΎΡ
ΡΠΎΠΌ Π245(558)-Π·Π°Π²ΠΈΡΠΈΠΌΡΠΌΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎ-ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΡΠΌΠΈ ΡΠ΅ΠΏΡΠΌΠΈ ΡΠΏΠ΅ΡΠΌΠ°ΡΠΎΠ·ΠΎΠΈΠ΄ΠΎΠ² ΠΊΡΡΡ, ΡΠΌΠ΅Π½ΡΡΠ°Π΅ΡΡΡ ΡΡΠΌΠΌΠ°ΡΠ½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ NO-ΡΠΈΠ½ΡΠ°Π· ΠΈ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΡΠΎΡΠΈΡΠ½ΡΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² ΠΏΠ΅ΡΠ΅ΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ², ΡΡΠΎ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΡΡΡ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΡΠΎΡΠ΅Π½ΡΠ° Π½Π΅ΠΆΠΈΠ·-Π½Π΅ΡΠΏΠΎΡΠΎΠ±Π½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈ ΠΈΡ
ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΡΠΌ, ΠΎΡΠΌΠ΅ΡΠ°Π΅ΡΡΡ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΡΠΏΠ΅ΡΠΌΠ°ΡΠΎΠ·ΠΎΠΈΠ΄ΠΎΠ² ΡΠΎ ΡΠ»ΠΎΠΆΠ½ΡΠΌΠΈ Π΄Π΅ΡΠ΅ΠΊΡΠ°ΠΌΠΈ (Π½Π΅ΡΠ°Π·Π΄Π΅Π»Π΅Π½Π½ΡΡ
, ΡΠΎ ΡΠΌΠ΅ΡΠ°Π½Π½ΡΠΌΠΈ Π°Π½ΠΎΠΌΠ°Π»ΠΈΡΠΌΠΈ), ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ Ρ Π±ΡΡΡΡΡΠΌ ΠΏΠΎΡΡΡΠΏΠ°ΡΠ΅Π»ΡΠ½ΡΠΌ Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ.
ΠΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΎ, ΡΡΠΎ Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠ° Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ NF-ΞΊB JSH-23 ΠΏΡΠΈ ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠ°Π΄ΠΈΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ (ΡΡΠ°ΠΊΡΠΈΠΎΠ½Π½ΠΎΠ΅ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ²ΡΠΊΠΎΠ΅ ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΠ΅ Π² ΡΡΠΌΠΌΠ°ΡΠ½ΠΎΠΉ Π΄ΠΎΠ·Π΅ 0,24 ΠΡ) ΠΈ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ (30-Π΄Π½Π΅Π²Π½Π°Ρ ΠΈΠ½ΡΠΎΠΊΡΠΈΠΊΠ°ΡΠΈΡ Π½ΠΈΡΡΠ°ΡΠΎΠΌ Π½Π°ΡΡΠΈΡ) ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΠΎΠ³ΡΠ°Π½ΠΈΡΠΈΠ²Π°Π΅Ρ Π² ΡΠΊΠ°Π½ΡΡ
ΡΠ΅ΠΌΠ΅Π½Π½ΠΈΠΊΠΎΠ² ΠΊΡΡΡ Π³Π΅Π½Π΅ΡΠ°ΡΠΈΡ ΡΡΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π½ΠΎΠ³ΠΎ Π°Π½ΠΈΠΎΠ½-ΡΠ°Π΄ΠΈΠΊΠ°Π»Π° Π΄ΡΡ
Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠ΅ΠΏΡΡ ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠΉ, ΡΠΌΠ΅Π½ΡΡΠ°Π΅Ρ Π² Π½ΠΈΡ
ΡΡΠΌΠΌΠ°ΡΠ½ΡΡ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ NO-ΡΠΈΠ½ΡΠ°Π·, ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ Π½ΠΈΡΡΠΈΡ-ΠΈΠΎΠ½ΠΎΠ² ΠΈ ΠΏΠ΅ΡΠΎΠΊΡΠΈΠ½ΠΈΡΡΠΈΡΠ°, ΠΏΠΎΠ²ΡΡΠ°Π΅Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΠΈΡΠΎΡ
ΡΠΎΠΌΠΎΠΊΡΠΈΠ΄Π°Π·Ρ, ΡΠ½ΠΈΠΆΠ°Π΅Ρ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΡ Π²ΡΠΎΡΠΈΡΠ½ΡΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² ΠΏΠ΅ΡΠ΅ΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ², ΠΏΠΎΠ²ΡΡΠ°Π΅Ρ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΡΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π», Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΡΡΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π΄ΠΈΡΠΌΡΡΠ°Π·Ρ ΠΈ ΠΊΠ°ΡΠ°Π»Π°Π·Ρ. Π ΡΠΏΠ΅ΡΠΌΠ΅ ΠΎΠ³ΡΠ°Π½ΠΈΡΠΈΠ²Π°Π΅ΡΡΡ Π³Π΅Π½Π΅ΡΠ°ΡΠΈΡ ΡΡΠΏΠ΅ΡΠΎΠΊΡΠΈΠ΄Π½ΠΎΠ³ΠΎ Π°Π½ΠΈΠΎΠ½-ΡΠ°Π΄ΠΈΠΊΠ°Π»Π° ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΡΠΌ ΠΈ ΠΠΠΠ€Π-ΡΠΈΡΠΎΡ
ΡΠΎΠΌ Π 450 ΠΈ ΠΠΠΠ€Π-ΡΠΈΡΠΎΡ
ΡΠΎΠΌ Π245(558)-Π·Π°Π²ΠΈΡΠΈΠΌΡΠΌΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎ-ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΡΠΌΠΈ ΡΠ΅ΠΏΡΠΌΠΈ ΡΠΏΠ΅ΡΠΌΠ°ΡΠΎΠ·ΠΎΠΈΠ΄ΠΎΠ² ΠΊΡΡΡ, ΡΠΌΠ΅Π½ΡΡΠ°Π΅ΡΡΡ ΡΡΠΌΠΌΠ°ΡΠ½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ NO-ΡΠΈΠ½ΡΠ°Π· ΠΈ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΠ΅ Π²ΡΠΎΡΠΈΡΠ½ΡΡ
ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ² ΠΏΠ΅ΡΠ΅ΠΊΠΈΡΠ½ΠΎΠ³ΠΎ ΠΎΠΊΠΈΡΠ»Π΅Π½ΠΈΡ Π»ΠΈΠΏΠΈΠ΄ΠΎΠ², ΡΡΠΎ ΡΠΎΠΏΡΠΎΠ²ΠΎΠΆΠ΄Π°Π΅ΡΡΡ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ΠΌ ΠΏΡΠΎΡΠ΅Π½ΡΠ° Π½Π΅ΠΆΠΈΠ·Π½Π΅ΡΠΏΠΎΡΠΎΠ±Π½ΡΡ
ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈ ΠΈΡ
ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠΎΡΠΌ, ΠΎΡΠΌΠ΅ΡΠ°Π΅ΡΡΡ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΡΠΏΠ΅ΡΠΌΠ°ΡΠΎΠ·ΠΎΠΈΠ΄ΠΎΠ² ΡΠΎ ΡΠ»ΠΎΠΆΠ½ΡΠΌΠΈ Π΄Π΅ΡΠ΅ΠΊΡΠ°ΠΌΠΈ (Π½Π΅ΡΠ°Π·Π΄Π΅Π»Π΅Π½Π½ΡΡ
, ΡΠΎ ΡΠΌΠ΅ΡΠ°Π½Π½ΡΠΌΠΈ Π°Π½ΠΎΠΌΠ°Π»ΠΈΡΠΌΠΈ), ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ Ρ Π±ΡΡΡΡΡΠΌ ΠΏΠΎΡΡΡΠΏΠ°ΡΠ΅Π»ΡΠ½ΡΠΌ Π΄Π²ΠΈΠΆΠ΅Π½ΠΈΠ΅ΠΌ.
ΠΡΠΎΠ²Π΅Π΄Π΅Π½Π½ΡΠ΅ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ ΡΡΠΈΡΠ°ΡΡ ΡΠ΅Π»Π΅ΡΠΎΠΎΠ±ΡΠ°Π·Π½ΡΠΌ Π΄Π°Π»ΡΠ½Π΅ΠΉΡΠ΅Π΅ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π²Π»ΠΈΡΠ½ΠΈΡ ΠΌΠ΅Π»Π°ΡΠΎΠ½ΠΈΠ½Π° ΠΈ ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠ² Π°ΠΊΡΠΈΠ²Π°ΡΠΈΠΈ NF-ΞΊB ΠΊΠ°ΠΊ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΡ
Π³ΠΎΠ½Π°Π΄ΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΠΎΠ² Ρ ΠΌΡΠΆΡΠΈΠ½, ΠΏΠΎΠ΄Π²Π΅ΡΠ³Π°ΡΡΠΈΡ
ΡΡ Π²Π»ΠΈΡΠ½ΠΈΡ ΠΈΠΎΠ½ΠΈΠ·ΠΈΡΡΡΡΠ΅Π³ΠΎ ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΡ ΠΈ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ ΡΠΎΠΊΡΠΈΡΠ½ΡΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΡΠΈΡΠΎΠ΄Ρ. ΠΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Ρ ΠΌΠ΅ΡΠΎΠΏΡΠΈΡΡΠΈΡ, Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΠ΅ Π½Π° ΡΠ°Π½Π½Π΅Π΅ Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΠ²ΠΈΠΉ Π½Π΅Π±Π»Π°Π³ΠΎΠΏΡΠΈΡΡΠ½ΠΎΠ³ΠΎ Π²Π»ΠΈΡΠ½ΠΈΡ ΠΊΠΎΠΌΠ±ΠΈΠ½ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Ρ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² ΠΈ ΡΠ΅Π½ΡΠ³Π΅Π½ΠΎΠ²ΡΠΊΠΎΠ³ΠΎ ΠΎΠ±Π»ΡΡΠ΅Π½ΠΈΡ.
This paper represents the evaluation of the results obtained in the experimental studies of effects produced by combined X-ray irradiation and sodium nitrate on testicles and sperm cells of the laboratory rats. The effects were assessed by the indices demonstrating the dynamics of oxidative and nitrative stress.
The studies have demonstrated the peculiarities of combined action produced by fractional X-ray irradiation in a total dose of 0.24 Gy and sodium nitrate on the bodies of laboratory rats that are manifested by the development of the following adverse effects in the testes as peroxynitrite formation, decompensated lipid peroxidation, and reduced activity of cytochrome oxidase. The adverse effects observed in the sperm cells of the rats include increasing overproduction of superoxide anion radical by mitochondrial electron transport chain, the total activity of NO-synthase and lipid peroxidation.
It has been shown the administration of melatonin and nuclear factor ΞΊB (NF-ΞΊB) inhibitor JSH-23 in experimental conditions significantly reduces testicular superoxide anion radical generation by mitochondrial respiratory chain, total NO-synthase activity, nitrite ions and peroxynitrite concentration, increases lipid peroxidation, decreases antioxidant capacity and activity of antioxidant enzymes β superoxide dismutase and catalase.
The studies carried out suggest that further study of the gonado-protective properties of melatonin and inhibitors of NF-ΞΊB activation would be of particular clinical importance as they could reduce the damaging effects produced by ionizing radiation and some other toxic factors on the human body
Resection interventions in the treatment of hepatocellular cancer in a specialized surgery center
Background. The relevance of the treatment of hepatocellular cancer (HCC) is determined by a significant increase in the incidence rate and its high prevalence among primary malignant hepatic tumors.The aim of the study. To summarize the experience of providing specialized medical care to patients with hepatocellular cancer.Methods. We studied the direct results of treatment of patients with primary hepatic cancer treated at the Kuzbass Regional Hepatological Center for the period from January 2015 to August 2022. The materials for the study were medical records of patients with an established diagnosis of primary hepatic cancer, surgical records, results of pathohistologic examination. The exclusion criterion was diagnosed cholangiocellular carcinoma.Results. During the period from 2015 to 2022, 59 patients with primary hepatic cancer were treated at the Kuzbass Regional Hepatological Center. Among them, hepatocellular cancer was diagnosed in 48 cases, cholangiocellular cancer β in 11 cases; radical surgery was performed in 12 patients with hepatocellular cancer; fatal outcome was noted in 1 (2.1 %) patient, complications in the postoperative period developed in 5 (41.7 %) cases and were ranked as I-3, IIIb-1 and IVb-1 according to Clavien β Dindo classification.Conclusion. The degree of risk of severe post-resection hepatic failure should be considered one of the main criteria in choosing a strategy for radical surgical treatment. New surgical approaches (laparoscopic vascular isolation of the portal blood flow, using temporary hemostasis in laparoscopic hepatic resections and the device for its implementation) in resection surgery of primary hepatic cancer can improve the immediate results of treatment
Poloidal inhomogeneity of the particle fluctuation induced fluxes near of the LCFS at lower hybrid heating and improved confinement transition at the FT-2 tokamak
This paper deals with the new spectral and microturbulence experimental data
and their analysis, which show, that the radial electric field Er generated at
the LH heating (LHH) in the FT-2 is high enough to form the transport barriers.
The ETB is formed when LHH is switched off. The radial fluctuation-induced
EB drift flux densities near LCFS in SOL are measured at two different
poloidal angles. For this purpose two Langmuir probes located at low and high
field sides of the torus are used. Registration of the poloidal and radial
components of the electric field and density fluctuations at the same time
during one discharge permits to measure the poloidal asymmetry of the transport
reduction mechanism of the radial and poloidal particle fluxes in the SOL. The
absolute E(~) fluctuation levels show dependence on the sign of Er
shear. The modification of the microscale turbulence by the poloidal Er x B
rotation shear EB at the L - H transition near LCFS is also
studied by X-mode fluctuation Reflectometry. The new data were obtained by
spatial spectroscopic technique.Comment: 12th International Congress on Plasma Physics, 25-29 October 2004,
Nice (France
- β¦