B2B relationship calculus: quantifying resource effects in service-dominant logic

Increasingly, knowledgeable business-to-business (B2B) customers and evolving customer needs are leading to seismic shifts in vendor–client interactions. Across industries, sellers are changing their business models from a simple goods orientation to a hybrid goods–services model, placing greater emphasis on delivering complete customer solutions. In such an environment, companies must find ways to prioritize investments in resource development. The service-dominant (S-D) logic framework offers significant insights into this challenge; however, these effects have not been tested quantitatively. This study addresses that gap, examining the influence of various seller resources on buyer satisfaction. An empirical analysis of buying organizations that purchased and implemented business intelligence systems finds that “augmented” operant resources that the buyers ascribe to the software’s sellers—resources that go above and beyond expectations—are the most significant predictors of both successful technology assimilation and overall customer relationship quality. In particular, an augmented operant resource reflecting a seller’s ability to see value creation opportunities from the buyer’s perspective (value mindset) has up to three times the effect on relationship satisfaction as “core” operant resources such as product-specific expertise or basic interpersonal service skills. These results can help sellers prioritize resource investments

Globular Cluster UVIT legacy Survey (GlobUleS) III. Omega Centauri in Far-Ultraviolet

We present the first comprehensive study of the most massive globular cluster Omega Centauri in the far-ultraviolet (FUV) extending from the center to ~ 28% of the tidal radius using the Ultraviolet Imaging Telescope aboard AstroSat. A comparison of the FUV-optical color-magnitude diagrams with available canonical models reveals that the horizontal branch (HB) stars bluer than the knee (hHBs) and the white dwarfs (WDs) are fainter in the FUV by ~ 0.5 mag than model predictions. They are also fainter than their counterparts in M13, another massive cluster. We simulated HB with at least five subpopulations, including three He-rich populations with a substantial He enrichment of Y up to 0.43 dex, to reproduce the observed FUV distribution. We find the He-rich younger subpopulations to be radially more segregated than the He-normal older ones, suggesting an in-situ enrichment from older generations. The Omega Cen hHBs span the same effective temperature range as their M13 counterparts, but some have smaller radii and lower luminosities. This may suggest that a fraction of Omega Cen hHBs are less massive than those of M13, similar to the result derived from earlier spectroscopic studies of outer extreme HB stars. The WDs in Omega Cen and M13 have similar luminosity-radius-effective temperature parameters, and 0.44 - 0.46 M$_\odot$ He-core WD model tracks evolving from progenitors with Y = 0.4 dex are found to fit the majority of these. This study provides constraints on the formation models of Omega Cen based on the estimated range in age, [Fe/H] and Y (in particular), for the HB stars.Comment: Accepted for publication in ApJL; 13 pages, 5 figures, 1 tabl

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Retrospective evaluation of whole exome and genome mutation calls in 746 cancer samples

Funder: NCI U24CA211006Abstract: The Cancer Genome Atlas (TCGA) and International Cancer Genome Consortium (ICGC) curated consensus somatic mutation calls using whole exome sequencing (WES) and whole genome sequencing (WGS), respectively. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2,658 cancers across 38 tumour types, we compare WES and WGS side-by-side from 746 TCGA samples, finding that ~80% of mutations overlap in covered exonic regions. We estimate that low variant allele fraction (VAF < 15%) and clonal heterogeneity contribute up to 68% of private WGS mutations and 71% of private WES mutations. We observe that ~30% of private WGS mutations trace to mutations identified by a single variant caller in WES consensus efforts. WGS captures both ~50% more variation in exonic regions and un-observed mutations in loci with variable GC-content. Together, our analysis highlights technological divergences between two reproducible somatic variant detection efforts

Salesperson reaction to management lead generation programs: The paradox investigated

Spiralling sales costs have caused researchers to explore several determinants of sales performance in order to make salespeople more productive. One avenue for raising productivity that is being pursued by companies is management lead generation programs. Management-generated leads are product- and service-related inquiries directed to the organization by potential customers as a result of exposure to different marketing communications aimed at them by the company, e.g., trade shows, advertisements in print media/public broadcast, telemarketing, direct mail, sales seminars, and product demonstrations. Lead generation programs are undertaken by organizations to help salespeople target better prospects, and consequently generate more sales with less effort, increase productivity, and yield more time to contact new prospects. Hence, it is expected that salespeople will greet leads with great enthusiasm. However, many companies are surprised to find their salespeople not following up on the generated leads. The above paradox, whereby salespeople treat leads with apathy despite postulated salesperson benefits of lead pursuit, is a major managerial dilemma, which has short term implications in terms of enormous wastage of management resources, and serious long term implications resulting from prospect dissatisfaction when salespeople fail to contact them. This demonstrates a need to study the management-lead follow-up phenomenon to get insights into the causes of the resistance of many salespeople to lead follow-up. This requires an understanding of what determines management-lead follow-up and whether salespeople actually gain from lead follow-up. This dissertation examines the paradox (zealous management, apathetic salespeople) by conducting a cross-industry field study to understand which salespeople are more likely to respond favorably to management leads, what are the critical influences on lead follow-up, and what is the impact of lead pursuit on salesperson performance. Data collected from a variety of firms and analyzed using Tobit, indicate that contrary to the traditional beliefs of management and trade press, salespeople predominantly act logically in their lead follow-up behavior. Further, investigation of the relationship between management-lead pursuit and salesperson performance, using OLS, shows positive relationship with a salesperson\u27s prospect conversion rate and new business performance

Between-ward disparities in colorectal cancer incidence and screening in Washington DC

This study aims to investigate the incidence and determinants of colorectal cancer (CRC) and its screening in District of Columbia (DC), and identify modifiable risk factors. Data (2000–2009) from the DC Cancer Registry, Behavioral Risk Factor Surveillance System (BRFSS-DC) and Surveillance Epidemiology and End Results (SEER) were used to estimate CRC incidence in eight DC Wards. Risk factors and CRC screening were analyzed using uni-, bi-, and multivariable statistical methods with survey procedures in SAS (version 9.2) including binary, unconditional multivariable logistic regression analysis. Factors measured included stage of diagnosis, age, gender, race/ethnicity, smoking, alcohol, exercise, body weight, health insurance, education, employment, and income. Over the study time, CRC screening increased from 48.4% to 68.6%. Mean age at diagnosis was 67 years. CRC incidence is high in DC. Furthermore, CRC incidence rates in DC below 50 years age were higher than the SEER18 average. Disparities exist between CRC incidence and screening among DC Wards. Identified risk factors for CRC are smoking, obesity, and low physical activity; screening was less prevalent among the uninsured and low socio-economic group. Local variations in CRC occurrence exist and may vary from average national experiences. Identification of local regions which vary from national trends in disease occurrence is important for comprehensive understanding of the disease in the community

Women, Migration and Development

The Women's Feature Service based in New Delhi, India covers daily stories of how women are coping with different forms of violence, including the perils of migration and trafficking, as well as the attempts by civil society and others to rectify the situation. Sharmila Joshi, Ruby O. Santos and Patralekha Chatterjee tell the stories of trafficked and migrating children and women in India and the Philippines. Development (2003) 46, 119–123. doi:10.1177/10116370030463019

Mucocutaneous changes in tuberous sclerosis complex: A clinical profile of 27 Indian patients

Background: Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disease resulting in a wide array of clinical manifestations, primarily affecting the skin and central nervous system. Mucocutaneous features play a very important role in the recognition of this syndrome. Aims: To review the prevalence and patterns of cutaneous manifestations in tuberous sclerosis, in a group of patients from eastern India. Methods: Observational clinical study on twenty-seven consecutive patients of tuberous sclerosis collected during a period of four years. Results: Most were between 10-20 years of age; the male to female ratio was 2:1. Family history was found in two-thirds. The classical triad of tuberous sclerosis was present in only nine (33.3&#x0025;) patients. Adenoma sebaceum was the most common cutaneous feature (100&#x0025;), followed by hypomelanotic macules (92.6&#x0025;), connective tissue nevi (66.6&#x0025;), and Koenen&#x2032;s tumors (33.3&#x0025;). Oral mucosal fibromas were seen in six (22.22&#x0025;) patients. Fibromatous plaque over forehead and scalp was seen in three patients. Limitation of the study was small size of study sample. Conclusion: Prominent mucocutaneous changes are extremely common manifestation of TSC, which may provide crucial diagnostic clues for primary care physicians