Netarsudil: a novel intra-ocular pressure lowering agent

Optic disc health is an important indicator of visual functions. The first line of management to prevent/halt the damage to optic disc is to control responsible pathological condition, if identified. In absence of identifiable cause, the most validated approach is lowering of intra-ocular pressure (IOP). Individually, as well as combinations of currently available drugs are not fully effective in all patients of glaucoma in achieving desired IOP control. Hence, there is a need of newer alternatives which address this unmet need. Recently, a newer IOP lowering agent with a novel mechanism of action, netarsudil, has been approved by United States Food and Drug Administration (US-FDA) in December 2017. Netarsudil acts by inhibiting Rho-associated protein kinase resulting in lowering of overall tone of the contractible cells in trabecular meshwork thereby improving drainage of aqueous humor outflow and lowering of IOP. Though in its early days, this drug gives an armamentarium to ophthalmologists and physicians to control IOP in patients of open-angle glaucoma and ocular hypertension

Limitations in assessing nerve growth factor levels in aqueous humor samples from human eyes

<p>Abstract</p> <p>Background</p> <p>Nerve growth factor (NGF) helps in the healing and survival of ganglion cells, photoreceptors, and optic nerve after injury and has been implicated to have a role in pathophysiology of glaucoma. So far, in animal studies, injury to iris in vitro has revealed an increase in NGF levels in aqueous. There is a great interest in investigating the levels of NGF in human aqueous in glaucomatous eyes, as suggested by animal studies, to gain a better understanding of the pathophysiology of glaucoma.</p> <p>Findings</p> <p>In this study, we examined the presence of NGF levels in aqueous humor collected from human eyes and the limitations in determining the NGF levels in human samples. NGF was assessed by ELISA immunoassay in undiluted aqueous samples collected from 32 consecutive patients undergoing surgery for cataract (control) or primary open angle glaucoma (POAG). Recombinant NGF was used as positive control. NGF levels were below undetectable levels in aqueous humor from eyes with POAG and controls by immunoassay. Less than 10% of samples had detectable NGF levels and these were considered outliers.</p> <p>Conclusion</p> <p>Our result highlights the undetectable levels of NGF in human aqueous samples.</p

Exploring the role of GIS during community health assessment problem solving: experiences of public health professionals

BACKGROUND: A Community health assessment (CHA) involves the use of Geographic Information Systems (GIS) in conjunction with other software to analyze health and population data and perform numerical-spatial problem solving. There has been little research on identifying how public health professionals integrate this software during typical problem solving scenarios. A better understanding of this is needed to answer the "What" and the "How". The "What" identifies the specific software being used and the "How" explains the way they are integrated together during problem solving steps. This level of understanding will highlight the role of GIS utilization during problem solving and suggest to developers how GIS can be enhanced to better support data analysis during community health assessment. RESULTS: An online survey was developed to identify the information technology used during CHA analysis. The tasks were broken down into steps and for our analysis these steps were categorized by action: Data Management/Access, Data Navigation, Geographic Comparison, Detection of Spatial Boundaries, Spatial Modelling, and Ranking Analysis. 27 CHA professionals completed the survey, with the majority of participants (14) being from health departments. Statistical software (e.g. SPSS) was the most popular software for all but one of the types of steps. For this step (detection of spatial boundaries), GIS was identified as the most popular technology. CONCLUSION: Most CHA professionals indicated they use statistical software in conjunction with GIS. The statistical software appears to drive the analysis, while GIS is used primarily for simple spatial display (and not complex spatial analysis). This purpose of this survey was to thoroughly examine into the process of problem solving during community health assessment data analysis and to gauge how GIS is integrated with other software for this purpose. These findings suggest that GIS is used more for spatial display while other software such as statistical packages (the "What") are used to drive data management, data navigation, and data calculation (the "How"). Focusing at the level of how public health problems are solved, can shed light on how GIS technology can be enhanced to encompass a stronger role during community health assessment problem solving

A Three Dimensional Lattice of Ion Traps

We propose an ion trap configuration such that individual traps can be stacked together in a three dimensional simple cubic arrangement. The isolated trap as well as the extended array of ion traps are characterized for different locations in the lattice, illustrating the robustness of the lattice of traps concept. Ease in the addressing of ions at each lattice site, individually or simultaneously, makes this system naturally suitable for a number of experiments. Application of this trap to precision spectroscopy, quantum information processing and the study of few particle interacting system are discussed.Comment: 4 pages, 4 Figures. Fig 1 appears as a composite of 1a, 1b, 1c and 1d. Fig 2 appears as a composite of 2a, 2b and 2

IMECE2005-80758 MODELLING CONDUCTION AND RADIATION IN REACTIVE POROUS BED OF THE GASIFIER

ABSTRACT This paper presents the heat transfer model for the gasifier to predict the temperature profile in the bed using the single zone sub-model. The single zone sub-model is also used to verify the correctness and to demonstrate the effect of various parameters for e.g. solid/fluid flow, temperatures of inflow/outflow control volume (CV), heat generation/absorption and with/without heat loss. The study shows that solid/fluid flow, inflow CV temperature and heat generation/absorption within the CV of interest are the strong influencing parameters, whether, the outflow CV temperature has insignificant effect on the temperature values of the CV of interest. The six similar zones correspond to preheating, drying, pyrolysis, oxidation, reduction and annular jacket zone are also coupled in order to predict the temperature profile in the gasifier bed. The simulation result shows that temperature of the down stream zones are more sensitive to heat generation in the bed as compared to upstream zone temperature, while the increase in gas flow rate resulting into the decrease in temperature profile depending upon the values of heat generation/absorption in bed is being fixed

PROSOPIS CINERARIA (L) DRUCE: A DESERT TREE TO BRACE LIVELIHOOD IN RAJASTHAN

The Prosopis cineraria (L) Druce is an important tree (Khejri- a local name in Rajasthan)for the Thar Desert withhard climatic adaptation and one of the lifeline in desert habitat as mentioned in ancient literature. This is a speciesrepresenting all five F viz., Forest, Fiber, Fuel, Fodder and Food. This tree is also mythological important in localcommunities. High value of this species recognized as a State symbol (state tree of Rajasthan). Prosopis cineraria(L.) Druce is a tree endemic to hot deserts of India, belonging to the family Leguminosae. Pods locally called“Sangri” are considered as dry fruit of desert and are one of the main ingredients of quintessential Rajasthani dish -The Panchkuta. In the present article, we have attempted to review different characteristics of the pods, tounderstand its health benefits. Various phytoconstituents like tannins (gallic acid), steroids (stigmasterol,campesterol, sitosterol, etc.), Flavone derivatives (prosogerin A, B, C, D, and E), alkaloids (spicigerine,prosophylline), etc. have been isolated from the sangri pods .As this plant is found in water stress (or deficient area)so antioxidant potential of pods has also been discussed. Prosopis cineraria (L) Druce is one of the highly valuedplant in the Indigenous System of Medicine. P. cineraria pods provide protein, iron, vitamins A and C and othermicro minerals Unripe pods are also nutritious and are used to prepare curries and pickles. Its bark is said to be apotent drug for several ailments such as leprosy, dysentery, bronchitis, asthma, leucoderma, piles, muscular tremors,asthma, rheumatism and inflammations. Pharmacological activities like analgesic, antipyretic, antihyperglycemic,antioxidant, antihypercholesterolemic, antitumor, nootropic anthelmintic, antibacterial, antifungal, antiviral andanticancer activities have been reported from different plant extracts. In view of its medicinal importance, thepresent review is focused to delineate its chemical constitution and therapeutic potentiality, precisely