EFFICACY OF PATRA POTTALI SWED & JANUBASTI IN OSTEOARTHRITIS W.S.R. TO KNEE JOINT (JANU-SANDHIVATA)

Osteoarthritis (OA) is a chronic degenerative disease in male while it affects female in younger age. Life style play major role in OA. In Osteoarthritis (Sandhigata vata) pain, swelling, restricted movements of joints are common clinical features. The insidious starting is with aching pain in the joint and relieved by the rest. The other associated symptom is stiffness, which aggravated after a long rest and subsides after by active movement. In this trial entitled efficacy of Patra pottli swed & Janubasti in osteoarthritis w.s.r. to knee joint (Janu-sandhivata) Patra pottali swed & janu basti are selected to treat the Osteoarthritis of knee joint (Janu sandhigata vata) for 90 patients. All the 90 patients were divided in three groups of 30 patients in each group with an Patra Pottali Swed (Nirgundi Patra), Janubasti (Dashmooladi tail) & combined therapy (Patra Pottali Swed & Janu basti).Swedan is indicated in Kapha vata pradhan vyadhi. swedan helps in remove stiffness, pain, heaviness and coldness. In this trail both therapy Patra pottali sed and Kati basti have based on Swedan properties. Acharya charak mentioned in Sagni swed (sankar swed) for Pottali seed. Both therapy are special indicate in Group– A (Patra Pottali Swed) & Group – B (Janubasti) are mild beneficial, statistically significant & Group – C (Patra Pottali Swed & Janu basti) is moderate beneficial, statistically highly significant

AYURVEDA A RAY OF HOPE FOR MULTIPLE SCLEROSIS W.S.R. TO ASTHI MAJJA GATA VATA: A CASE STUDY

Multiple sclerosis (MS) is a demyelinating disease in which the insulting covers of nerve cells in the brain and spinal cord are damaged. The course of MS is usually relapsing-remitting and sometimes progressive. It is the commonest inflammatory- demyelinating disease of the CNS and the most frequently occurring cause of non traumatic neurologic disability in young and middle aged adults. Immunosuppressant or cortico­­-steroids as only available treatment in modern science, Ayurveda only the ray of hope. In Ayurveda, multiple Sclerosis can be correlated with Asthi – Majjagatavata. Aim: A case study had been done to find effective management for MS. A 35 year old female patient came to Panchkarma OPD, Dr. S.R. Rajasthan Ayurved University, Jodhpur was suffering from Weakness, Numbness and burning sensation in both arms or legs and Numbness in abdominal region and lack of coordination for 18months.she was diagnosed case of multiple sclerosis (kurtzke disability grade Five) had been given Ayurvedic medicine as well as Panchkarma shown encouraging results. Conclusion: Patient was observed for symptomatic improvement based assessment done by questionnaire, also observed for clinical examination. Patient was also observed for complication during whole course of treatment, untoward complications were not seen. Conservative management of MS through Ayurvedic principles improving the quality of life and decrease dependency of patient. Result: Patient showed improvement kurtzke disability grade Five to grade two

PANCHKARMA MANAGEMENT OF SPASTIC DIPLEGIC CEREBRAL PALSY IN CHILDREN: A SINGLE CASE STUDY

Cerebral Palsy is a neurological disorder that affects a child’s movement, motor skill and muscle tone. The present case is of a patient having Spastic diplegic Cerebral Palsy which was successfully managed with Panchakarma treatment. A four year old boy complaint of global developmental delay with predominantly gross developmental delay, can’t feed himself, unable to sit without support, does not roll over, has age appropriate non-verbal communication was treated with Panchakarma procedures. The Ayurvedic diagnosis of the case was Shiro-Marmabhighatajsankochajanyavatavyadhi. We have formulated an Panchakarma therapy protocol to improve the condition of spastic diplegic CP patients. Result was observed in the form of GMFCS Level and significant changes in investigations

SYSTEM FOR HEALTH EVALUATION INVOLVING DYNAMICALLY GROUPED ENTITIES

In observability and monitoring solutions, metrics can be collected for entities and health status for the entities can be evaluated based on certain rules. Health evaluation and reporting typically occurs on the same entities on which such metrics are collected/ingested. However, there are instances in which this approach may not suffice, such as instances in which metrics may need to be derived for parent entities based on child entities. Presented herein are techniques through which virtual entities can be dynamically introduced in order to derive metrics, health status, etc. for a parent entity based on child entity metrics

Evaluating the effect of dexmedetomidine premedication on the quality of subarachnoid block, haemodynamics and sedation in patients undergoing lower limb surgeries: a prospective randomized controlled trial

Background: Present study was designed to evaluate the effect of intravenous dexmedetomidine on haemodynamics, sedation and quality of spinal anaesthesia with 0.5% hyperbaric bupivacaine.Methods: Sixty ASA grade 1 and 2, 18-60 years aged patients scheduled for elective lower limb surgeries were randomly divided into two groups: Group C (Control) and Group D (Study), received intravenous normal saline 10ml and intravenous dexmedetomidine 1μg/kg in dilution of 10ml respectively over 10minutes duration, 10minutes before subarachnoid block with 2.5ml of 0.5% hyperbaric bupivacaine. The heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), quality of sensory and motor block and level of sedation were monitored intraoperatively and postoperatively.Results: The heart rate was statistically significantly decreased in group D both intraoperatively and postoperatively. Intraoperative and postoperative SBP and DBP were lower in dexmedetomidine group but clinically that was insignificant. Intraoperative Ramsay sedation scores were significantly higher in dexmedetomidine group (3.49±0.240) as compared to control group (2.51±0.249) (p<0.001) but the patients were easily arousable. The duration of sensory blockade (208.83±9.53 min vs 162.83±9.62 min), duration for 2 dermatomal regression of sensory blockade (146.5±10.013min vs 98±8.57min) and the duration for motor block regression to Modified Bromage scale 0 (167.33±10.5min vs 137.83±11.94min) were significantly prolonged in dexmedetomidine group as compared to control group. The highest level of sensory blockade was also significantly higher in dexmedetomidine group (T6.90±0.759 vs T7.60±0.621). There was no difference in the time for attaining highest level of sensory blockade, time taken for motor blockade to reach Modified Bromage Scale 3 between both the groups. Average 24hr mean VAS score was significantly lower in dexmedetomidine group (1.37±0.15 vs1.72±0.17, p<0.001). Time to first request for rescue analgesic was also significantly longer in dexmedetomidine group (mean 174.33min vs 143.5min). Average 24hour consumption of tramadol analgesic was significantly higher in control group as compared to dexmedetomidine group (391.86±111.62mg vs 279.86±80.55mg, p<0.001).Conclusions: Intravenous dexmedetomidine significantly prolongs the duration of sensory and motor block of bupivacaine spinal anaesthesia. It provides excellent sedation and analgesia. Dexmedetomidine induced decrease in heart rate, systolic/diastolic blood pressure are not clinically significant.

Correlation of anthropometric indices by cardio vascular index in young adult having obesity

Background: The aim of this study is to correlate anthropometric indices with hemodynamic vascular changes in young adult obese patients. Methods: It is case-control study, 140 patients were recruited. Which were divided into two group i.e., study group=70 and control group=70. Anthropometric measurement waist circumference (WC) and total body fat percentage (TBF%) of each patient is compared with right brachial pulse wave velocity (PWV) (dominant hand). Results: Obese individuals had high levels of PWV as compared with non obese patients. Study suggested that cardiovascular parameter levels were significantly increased in obese patients, these same patients gradually progress towards the hypertensive condition. Conclusions: Changes in cardiac function are common in obese patients, hence, there is need for periodical assessment of the cardiac function and anthropometric measurement and PWV as cardiac markers in obese patients proves to be an early and simple tool to give warning signal for the patients to take early preventive measures

Synthesis, characterization and optical properties of CdSe/CdS and CdSe/ZnS core-shell nanoparticles

Controlled organic synthesis method used for the preparation of cadmium selenide (CdSe) quantum dots, which are covered with cadmium sulfide (CdS) and zinc sulfide (ZnS) using TOP mediated has been presented in this paper. The size, shape, internal structure, chemical composition and functional groups of the core-shell nanoparticles were analyzed using X-ray diffraction, transmission electron microscopy, high resolution transmission electron microscopy, energy dispersive spectra and FTIR. These studies show that the particle size is in 2-10 nm range with hexagonal phase. The optical properties were analyzed through UV-visible spectroscopy, photoluminescence spectroscopy and micro-Raman spectroscopy. Photoluminescence blue shift and broadening of Raman spectrum further confirm the narrow size of particles