ROLE OF PATHYA-APATHYA AND YOGIC PROCEDURES IN THE MANAGEMENT OF COPD

Chronic Obstructive Pulmonary Disease (COPD) is a chronic lung disease that is often preventable and treatable. In Ayurvedic texts Shwasa Roga has been described having symptomatology close to COPD. COPD damages the airways in lungs and leads to shortness of breath, impacting patient`s work, exercise, sleep and other everyday activities. More than 11 million people in the U. S. suffer from COPD and its prevalence has been increasing steadily over the past 20 years. It causes serious long-term disability and early death. COPD includes both chronic bronchitis and emphysema. Risk factor includes exposure to air pollution, second-hand smoke and occupational dusts and chemicals, smoking, cold weather etc. which are also mentioned in Ayurvedic classics. Identification, reduction and control of risk factors to prevent the onset of COPD are important steps towards developing strategies for prevention of COPD. The aims and objectives of Ayurveda are to maintain the health of a healthy person and to cure the diseases of the patients. It is signifies that “prevention is better than cure.” To maintain the health, Ayurveda laid many basic principles like Ritucharya (seasonal regime), Dincharya (diumal regime) etc. The Yogic procedures and the concept of Pathya (wholesome) and Apathya (unwholesome) is the peculiarity of Ayurveda for the management of COPD and the treatment module includes- Panchakarma (Vamana, Virechana, Dhumapana and Nasya), external therapies (Lepas, Dhara, Sthanika Abhayanga and Swedana) and internal medications are very effective in COPD

A comparative study of attitudes towards COVID-19 vaccination in the rural and urban population of Uttarakhand, India

Background The public is hesitant about getting vaccinated for COVID-19, and a few people are still avoiding it. The aim of this study was to evaluate the attitude towards COVID-19 vaccination among rural and urban populations of the Dehradun district in Uttarakhand, India. Materials and methods A cross-sectional survey was conducted from April to June 2021 in selected urban and rural areas of the Dehradun district, yielding 770 responses (385 from both rural and urban areas). The attitudes towards COVID-19 vaccination were collected via questionnaire and analysed using descriptive and inferential statistics. Results There were no rural-urban differences in the mean score of attitude towards COVID-19 vaccination (49.22±12.89 vs 50.01 ±11.88; P=0.379). The majority of participants had a neutral to positive attitude, and very few had a negative attitude towards COVID-19 vaccination, equally in the rural and urban population. A significant positive association was found between attitude scores with COVID-19 vaccination and mortality among participant’s relatives and friends in rural areas, while participant occupation and number of family members in the urban area were associated with a more positive attitude. Conclusion These results suggest mainly neutral attitude among the rural and urban populations towards COVID-19 vaccination. Therefore, it is important to design and implement innovative and efficient communication strategies to influence the neutral and offset the negative attitudes regarding vaccination drive to facilitate immunisation outreach and coverage

Role of Panchakarma in the management of Migraine (Ardhavabhedaka) : A Review

Headache is one among the most common reasons patients seek medical attention, on a global basis being responsible for more disability than any other neurological problem. Migraine is the 2nd most common primary headache, also known as ‘Hemicrania’, means ‘half of the head’. It constitutes 16% of the primary headache and affects ~10-20% of general population, i.e. about 15% of women and 6% of men. It is characterized by recurrent episodes of headache that is moderate to severe and pulsatile in nature and lasting for 2-72 hours. Associated symptoms are nausea, vomiting, sensitivity to light, sound, or smell. It is not a lethal disorder but it can disturb patient’s life very widely, so its treatment requires more attention and care. Unfortunately, there is no preventive medication for migraine has been stabilized so far, only symptomatic medication are available, which medications have a lot of adverse effects and make dependence. In Ayurveda it can be correlated to Ardhavabhedaka. Very elaborative treatment has been given in Ayurvedic Samhitas; especially Panchakarma offers significant relief in this disease

Deep Rooting In-Situ Expansion of mtDNA Haplogroup R8 in South Asia

The phylogeny of the indigenous Indian-specific mitochondrial DNA (mtDNA) haplogroups have been determined and refined in previous reports. Similar to mtDNA superhaplogroups M and N, a profusion of reports are also available for superhaplogroup R. However, there is a dearth of information on South Asian subhaplogroups in particular, including R8. Therefore, we ought to access the genealogy and pre-historic expansion of haplogroup R8 which is considered one of the autochthonous lineages of South Asia.Upon screening the mtDNA of 5,836 individuals belonging to 104 distinct ethnic populations of the Indian subcontinent, we found 54 individuals with the HVS-I motif that defines the R8 haplogroup. Complete mtDNA sequencing of these 54 individuals revealed two deep-rooted subclades: R8a and R8b. Furthermore, these subclades split into several fine subclades. An isofrequency contour map detected the highest frequency of R8 in the state of Orissa. Spearman's rank correlation analysis suggests significant correlation of R8 occurrence with geography.The coalescent age of newly-characterized subclades of R8, R8a (15.4+/-7.2 Kya) and R8b (25.7+/-10.2 Kya) indicates that the initial maternal colonization of this haplogroup occurred during the middle and upper Paleolithic period, roughly around 40 to 45 Kya. These results signify that the southern part of Orissa currently inhabited by Munda speakers is likely the origin of these autochthonous maternal deep-rooted haplogroups. Our high-resolution study on the genesis of R8 haplogroup provides ample evidence of its deep-rooted ancestry among the Orissa (Austro-Asiatic) tribes

Phylogenetic analysis, based on EPIYA repeats in the cagA gene of Indian Helicobacter pylori, and the implications of sequence variation in tyrosine phosphorylation motifs on determining the clinical outcome

The population of India harbors one of the world’s most highly diverse gene pools, owing to the influx of successive waves of immigrants over regular periods in time. Several phylogenetic studies involving mitochondrial DNA and Y chromosomal variation have demonstrated Europeans to have been the first settlers in India. Nevertheless, certain controversy exists, due to the support given to the thesis that colonization was by the Austro-Asiatic group, prior to the Europeans. Thus, the aim was to investigate pre-historic colonization of India by anatomically modern humans, using conserved stretches of five amino acid (EPIYA) sequences in the cagA gene of Helicobacter pylori. Simultaneously, the existence of a pathogenic relationship of tyrosine phosphorylation motifs (TPMs), in 32 H. pylori strains isolated from subjects with several forms of gastric diseases, was also explored. High resolution sequence analysis of the above described genes was performed. The nucleotide sequences obtained were translated into amino acids using MEGA (version 4.0) software for EPIYA. An MJ-Network was constructed for obtaining TPM haplotypes by using NETWORK (version 4.5) software. The findings of the study suggest that Indian H. pylori strains share a common ancestry with Europeans. No specific association of haplotypes with the outcome of disease was revealed through additional network analysis of TPMs

Reconstructing the demographic history of the Himalayan and adjoining populations

The rugged topography of the Himalayan region has hindered large-scale human migrations, population admixture and assimilation. Such complexity in geographical structure might have facilitated the existence of several small isolated communities in this region. We have genotyped about 850,000 autosomal markers among 35 individuals belonging to the four major populations inhabiting the Himalaya and adjoining regions. In addition, we have genotyped 794 individuals belonging to 16 ethnic groups from the same region, for uniparental (mitochondrial and Y chromosomal DNA) markers. Our results in the light of various statistical analyses suggest a closer link of the Himalayan and adjoining populations to East Asia than their immediate geographical neighbours in South Asia. Allele frequency-based analyses likely support the existence of a specific ancestry component in the Himalayan and adjoining populations. The admixture time estimate suggests a recent westward migration of populations living to the East of the Himalaya. Furthermore, the uniparental marker analysis among the Himalayan and adjoining populations reveal the presence of East, Southeast and South Asian genetic signatures. Interestingly, we observed an antagonistic association of Y chromosomal haplogroups O3 and D clines with the longitudinal distance. Thus, we summarise that studying the Himalayan and adjoining populations is essential for a comprehensive reconstruction of the human evolutionary and ethnolinguistic history of eastern Eurasia

Development of tire force state eliminator

Development of tire force state eliminatorDevelopment of tire force state eliminato