Medicinal plants used for treating infertility and related disorders of women in India: a systematic review

Assessment of plant medicine for treating infertility and related disorders is making headway universally recent couple of decades to bring out new effective and safe substances as an alternative medicine. Present paper reviews the published literature on plant medicine used for female infertility and related disorders. The 53 research papers or reports shortlisted are based studies under taken in India. Total 459 uses of 202 medicinal plants classified under 84 families. Total 62 trees, 55 shrubs, 79 herbs and 3 climbers are reported. Most used plant parts for making medicine are roots in 111 formulations and leaf in 101 formulations. Medicinal plants used for infertility are 84, while for related disorder like leucorrhoea 79 plants, menorrhagia 53, dysmenorrhea 29, amenorrhea 23 and 22 plants used to regulate menstruation. Additional investigations could be helpful to verify the claims reported using a specific formulations or recipes and which will subsequently result in providing possible the alternative medicine for the treatment of female infertility

Medicinal plants used during pregnancy, childbirth and postpartum care in India: a systematic review

Use of plant medicine during pregnancy, childbirth and in postpartum care has grown significantly worldwide and is remarkably well-known in different regions of India. Traditional plant medicine has the potential for treating various diseases/ailments and is evidenced by well-known pharmacopeia of India - Ayurveda. This paper reviews the research papers on plant medicine utilization during pregnancy, childbirth and for postpartum care based on information published from India. Total 206 uses of 146 medicinal plants belong to 69 families, of which 125 are herbs, 39 trees, 26 shrubs and 16 climbers. Plant parts used as medicine for treating various disorders during pregnancy, childbirth and postpartum are 75 leaves, 48 roots, 23 seeds, 19 whole plants, 15 fruits, 11 barks, stem and flower 5 each, gum 2, latex 1, while in 24 cases part used is not specified. The use of plants for treating various disorder/ailments during pregnancy, of these most prevalent use is as a tonic (23 uses) which followed by vomiting (10), abdominal pain (9), to facilitate delivery (6) and so on. Use of plants during childbirth, maximum number of plants used to facilitate deliver (32 uses), for labor pain (15), and to induce labor (12). While use of plants for postpartum care, includes (37 uses) for lactation, (10) for haemorrhage, and 7 for abdominal pain.

Vaginal birth after multiple caesarean section: a case report from India

Lower segment caesarean sections increase the possibility of maternal morbidity. Hence, since last few decades, initiative for trial of labor after caesarean delivery is being encouraged in selected cases. Accordingly, a 23-year-old fifth gravida, who had a history of previous three lower segment caesarean sections and one vaginal birth approached for delivery service and plan for her vaginal delivery was made after thorough examination and evaluation.  A live female child of 3100 grams was delivered following episiotomy. In post-partum period, it was observed that uterus was involuted on abdominal examination and uterine contours were regular in ultrasonography. As the evidences for practice of vaginal delivery in women who underwent 2 or more previous LSCS are still fewer, this report intends to highlight the possibility of successful vaginal birth after multiple caesarean sections

Patterns and causes of maternal mortality in tertiary care hospital in Maharashtra, India: a 10-year retrospective study

Background: Maternal death is a catastrophe, as death of a mother can the entire family. The aim of present study is to find out major patterns, reasons and complications leading to maternal deaths. Methods: A retrospective study was conducted for last 10 years from January 2013 to December 2022 by studying the records of a tertiary care hospital to study the maternal mortalities and complications leading to death. Maternal deaths were analyzed by considering different facets, such as age at death, gravida, locality of residence, admission death interval and direct and indirect cause/s of death, etc. Results: During the study period, total of 107753 live births and 202 maternal deaths have been recorded. The average maternal mortality rate of last ten years was 187.46/100000 live births. Age wise maternal mortality during the study period was high in the age 19 to 25. Major direct cause of maternal mortality was postpartum hemorrhage, (23%) and major indirect cause observed was anemia (43%). Admission to death interval time indicates that delay in provision of treatment and referral to tertiary care hospital might be the reason responsible for high maternal deaths. Conclusions: Maternal deaths can be prevented by improving the health care facilities, ensuring skilled attendants and required basic medication. This is high time to mobilize universal, national, regional, and community-based commitment to decrease maternal mortalities.

Design, synthesis and anti-inflammatory evaluation of PEGylated 4-methyl and 4, 8-dimethylcoumarins

Aberrant interaction between the leukocyte and the endothelial cell (EC) resulting from the deregulated expression of cell adhesion molecules (CAMs) on the endothelium results in uncontrolled inflammation leading to various inflammatory disorders. The existing drugs used to modulate the cytokine-induced expression of cell molecules have severe side effects. Therefore, there is an unmet therapeutic need to develop potent and safe drugs to treat inflammatory disorders. In the present study, novel PEGylated and non-PEGylated 4-methyl and 4,8-dimethylcoumarin derivatives were designed, synthesized and, evaluated for ICAM-1 inhibitory activity. The PEGylated coumarins were synthesized in two different ways. In the first approach, diesters of 4-methyl and 4,8-dimethylcoumarin were co-polymerized, separately with poly(ethylene glycol) using Candida antarctica lipase under solventless conditions. In the other approach, 4-methyl and 4,8-dimethylcoumarins were suitably converted to their bromo analogues and were tethered to already synthesized PEGylated polymers. Synthesized derivatives were evaluated for anti-inflammatory activities with respect to their ability to inhibit the TNF-α induced ICAM-1 (intercellular cell adhesion molecule-1) on human endothelial cells. It was found that PEGylated 4-methyl and 4,8-dimethylcoumarin derivatives were more effective than their non-PEGylated analogues to inhibit ICAM-1 expression. The present study opens new vista for PEGylated non-steroidal anti-inflammatory compounds and their further investigations

Synthesis and anti-inflammatory activity evaluation of novel triazolyl-isatin hybrids

New isatin-triazole based hybrids have been synthesized and evaluated for their inhibitory activity of TNF-α induced expression of Intercellular Adhesion Molecule-1 (ICAM-1) on the surface of human endothelial cells. Structure-activity relationship (SAR) studies revealed that the presence of the electron-attracting bromo substituent at position-5 of the isatin moiety played an important role in enhancing the anti-inflammatory potential of the synthesized compounds. Z-1-[3-(1H-1,2,4-Triazol-1-yl)propyl]-5-bromo-3-[2-(4-methoxyphenyl)hydrazono]indolin-2-one (19) with an IC50 = 20 μM and 89% ICAM-1 inhibition with MTD at 200 μM was found to be the most potent of all the synthesized derivatives. Introduction of 1,2,4-triazole ring and electron-donating methoxy group on the phenylhydrazone moiety resulted in four-fold increase of the anti-inflammatory activity.status: publishe

Synthesis and anti-inflammatory activity evaluation of novel triazolyl-isatin hybrids

<p>New isatin-triazole based hybrids have been synthesized and evaluated for their inhibitory activity of TNF-α induced expression of Intercellular Adhesion Molecule-1 (ICAM-1) on the surface of human endothelial cells. Structure-activity relationship (SAR) studies revealed that the presence of the electron-attracting bromo substituent at position-5 of the isatin moiety played an important role in enhancing the anti-inflammatory potential of the synthesized compounds. Z-1-[3-(1<i>H</i>-1,2,4-Triazol-1-yl)propyl]-5-bromo-3-[2-(4-methoxyphenyl)hydrazono]indolin-2-one (<b>19</b>) with an IC₅₀ = 20 μM and 89% ICAM-1 inhibition with MTD at 200 μM was found to be the most potent of all the synthesized derivatives. Introduction of 1,2,4-triazole ring and electron-donating methoxy group on the phenylhydrazone moiety resulted in four-fold increase of the anti-inflammatory activity.</p