State-of-Art Functional Biomaterials for Tissue Engineering

Nanobiotechnology-enabled tissue engineering strategies have emerged as an innovative and promising technique in the field of regenerative medical science. The design and development of multifunctional smart biomaterials compatible to human physiology is crucial to achieve the required biological function with a reduced negative biological response. Several medical bioimplants have been tested to boost life expectancy and better-quality life. The concept of biocompatibility focuses on body acceptance and no harmful effects after implantation, which require shaping the properties of materials synthesis, surface functionalization, and biofunctionality. Such developed bioactive and biodegradable materials have been utilized to achieve the required function at a specific period and sustainability to withstand the surrounding tissues for treating severe injuries and diseases. Thus, exploring new approaches to design multifunctional biocompatible advanced nanostructures to develop next-generation therapies for tissue engineering, this mini-review is an attempt to summarize the advancements in biofunctional smart materials. The review focuses on bio-mimic materials, biomaterials, self-assembly biomaterials, bioprinting functional hydrogels, new polymeric architectures, and hybrid synthetic–natural hydrogels in the field of tissue engineering and regenerative medicine (TERM). This mini-review will serve as a guideline to design future research where the selection of a smart multifunctional biomaterial is crucial to obtain best TERM performance

Formulation Development and Evaluation of Gastroretentive Delivery System (Microspheres) Using Natural Polymer

Microspheres are novel drug delivery approach to control release of pharmacologically active ingredient as per patient need. Natural polymers like fenugreek mucilage are cheap, biodegradable and have been proved safe for pharmaceutical formulation. Higher loading efficiency was observed for all the formulations and also the drug release was observed for the period of 12 hours. Thus, the simvastatin microsphere using fenugreek mucilage showed promising results in retarding the drug release. It can be concluded from whole study that due to the formation of polymeric network system or other active moiety can be easily entrapped with the matrix and hydration and swelling of natural polymer controlled their release patter

Chemo protective activity of Phyllanthus niruri and Opuntia ficus indica plant extract

Cancer is one of the leading causes of death. Several chemotherapeutical agents have been used to treat cancer, and yet a convincing cure is elusive in most cases. Therefore, there is continued need for development of new anticancer agents. Angiogenesis is one of the vital events for organ development and differentiation during embryogenesis as well as wound healing and reproductive functions in adults. Angiogenesis also contributes significantly to tumors growth and metastasis. Currently, search for effective anti-angiogenesis agents and therapy is an emerging field. Cytotoxic agents with anti-angiogenic activity are designated to control tumors endothelial cell growth and tumour cell survival. Therefore, combinatorial therapy in which anti-angiogenic agents with chemotherapeutic activity administrated in a scheduled manner could result in a much more favorable therapeutic effect. India is one of the richest bio diversity centers with respect to medicinal plants. Many plants have been utilized in the traditional system of medicine for cancer treatment. The plants have been utilized as medicines from thousands of years ago. The isolation of active components from plants began with the morphine isolation from opium plant. In the present study, Phyllanthus niruri and Opuntia ficus-indica were screened for the phytochemical and anticancer evaluation. Keywords: Anti-Cancer, Anti-Oxidant, Phyllanthus niruri, Opuntia ficus-indica, in vivo study