Exterior powers in Iwasawa theory

The Iwasawa theory of CM fields has traditionally concerned Iwasawa modules that are abelian pro-p Galois groups with ramification allowed at a maximal set of primes over p such that the module is torsion. A main conjecture for such an Iwasawa module describes its codimension one support in terms of a p-adic L-function attached to the primes of ramification. In this paper, we study more general and potentially much smaller Iwasawa modules that are quotients of exterior powers of Iwasawa modules with ramification at a set of primes over p by sums of exterior powers of inertia subgroups. We show that the higher codimension support of such quotients can be measured by finite collections of p-adic L-functions under the relevant CM main conjectures.Comment: 41 pages, to appear in J. Eur. Math. So

Chemical composition and antifungal effects of three species of Satureja (S. hortensis, S. spicigera, and S. khuzistanica) essential oils on the main pathogens of strawberry fruit

Due to an increasing risk of chemical contamination upon the application of synthetic fungicides to preserve fresh fruits and vegetables, essential oils are gaining increasing attentions. In this research, besides chemical analysis of the essential oils of three Satureja species (S. hortensis, S. spicigera, and S. khuzistanica) by GC-MS, their fungicidal and/or fungistatic effects on postharvest pathogens of strawberry were investigated. Essential oils were extracted by means of hydro-distillation and afterwards GC/MS analysis was performed to identify their components. Carvacrol, γ-terpinene and p-cymene were detected as the repeating main constituents of the spices, while thymol and carvacrol methyl ether were found as major components only in S. spicigera oil. In vitro results showed that at the maximum concentration, the essential oils did not possess fungicidal effects on Aspergillus niger but they exhibited fungicidal activities against Penicillium digitatum, Botrytis cinerea and Rhizopus stolonifer. However, S. khuzistanica was the strongest oil in fungicidal activity. S. hortensis oil was more effective than S. spicigera against B. cinerea whereas S. spicigera oil showed stronger fungicidal activity against R. stolonifer. In conclusion, essential oils isolated from three savory species could be suitable for applications in the food industry to control molds and improve the safety of fruits and vegetables. © 2015 Elsevier B.V

Phytochemical compositions and biological activities of essential oil from Xanthium strumarium L

The chemical composition of the essential oil (EO) from fresh cocklebur (Xanthium strumarium L.) leaves was investigated by GC-MS. The antimicrobial activity of the EO was tested against Gram-positive and Gram-negative bacteria and fungi. Scolicidal activity was assayed against Echinococcus granulosus protoscolices. In total, 34 compounds were identified, accounting for 98.96% of the EO. The main compounds in the EO were cis-\u3b2-guaiene (34.2%), limonene (20.3%), borneol (11.6%), bornyl acetate (4.5%), \u3b2-cubebene (3.8%), sabinene (3.6%), phytol (3.1%), \u3b2-selinene (2.8%), camphene (2.2%), \u3b1-cubebene (2.4%), \u3b2-caryophyllene (1.9%), \u3b1-pinene (1.8%) and xanthinin (1.04%). The antibacterial and antifungal screening of the EO showed that all assayed concentrations significantly inhibited the growth of Staphylococcus aureus, Bacillus subtilis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Candida albicans and Aspergillus niger (MIC = 0.5 \ub1 0.1, 1.3 \ub1 0.0, 4.8 \ub1 0.0, 20.5 \ub1 0.3, 55.2 \ub1 0.0 and 34.3 \ub1 0.0 \ub5g/mL, respectively). The scolicidal assay indicated that the EO exhibited a significant activity against E. granulosus protoscolices. To the best of our knowledge, this is the first report on the scolicidal activity of X. strumarium. Because of the emergence of antimicrobial drug resistance, the study of new effective natural chemotherapeutic agents, such as the X. strumarium EO, possibly with low side effects, represents a very promising approach in biomedical research

Modulation of the hepatocyte rough endoplasmic reticulum single chloride channel by nucleotide-Mg 2+ interaction

The effect of nucleotides on single chloride channels derived from rat hepatocyte rough endoplasmic reticulum vesicles incorporated into bilayer lipid membrane was investigated. The single chloride channel currents were measured in 200/50 mmol/l KCl cis/trans solutions. Adding 2.5 mM adenosine triphosphate (ATP) and adenosine diphosphate (ADP) did not influence channel activity. However, MgATP addition inhibited the chloride channels by decreasing the channel open probability (Po) and current amplitude, whereas mixture of Mg 2+ and ADP activated the chloride channel by increasing the Po and unitary current amplitude. According to the results, there is a novel regulation mechanism for rough endoplasmic reticulum (RER) Cl - channel activity by intracellular MgATP and mixture of Mg 2+ and ADP that would result in significant inhibition by MgATP and activation by mixture of Mg 2+ and ADP. These modulatory effects of nucleotide-Mg 2+ complexes on chloride channels may be dependent on their chemical structure configuration. It seems that Mg-nucleotide-ion channel interactions are involved to produce a regulatory response for RER chloride channels. © Springer-Verlag 2012

Bottom-up Effects of Substrate on Two Adjacent Shrub Communities and the Distribution of a Rare and Endangered Plant Species, Astragalus jaegerianus Munz.

Edaphic habitats are botanically interesting because of differences in vegetation with neighboring sites and because they tend to harbor rare species. In the central Mojave Desert, there are granite colluvial substrates where creosote bush, the dominant shrub in the area, is sparser and generally smaller than in the neighboring creosote bush communities. It is on these sites that the Lane Mountain milkvetch, a rare and federally endangered species, is restricted. The milkvetch is a nitrogen-fixer and grows under and within the canopy of host shrubs. Our previous studies have demonstrated that the milkvetch has no preference for species of host shrub, except Larrea tridentata, which appears to be an unsuitable host plant for the milkvetch. In this study, we surveyed three transects within milkvetch habitats and three transects in adjacent creosote bush habitats in the year 2000 and again in 2010, a period coincident with long-term drought conditions in the Mojave Desert. Our results show that adjacent milkvetch and creosote bush shrub communities differ significantly in shrub height, shrub volume, and shrub density in the year 2000: the shrubs in milkvetch communities were more numerous but smaller compared to adjacent creosote bush scrub. Species richness also differed between communities in the year 2000: milkvetch communities contained 19 different shrub species and creosote bush communities had only 9 species. Surveys in 2010 show that the drought had significant negative effects on both shrub communities. Total shrub mortality (166 shrubs) was high compared to shrub recruitment (16 shrubs), and the majority of mortality and recruitment occurred in milkvetch communities (131 deaths and 16 recruits). Shrub densities decreased significantly in milkvetch communities in 2010, but were still considerably higher than in creosote bush communities. These results suggest that the restricted distribution of the Lane Mountain milkvetch may be the result of higher shrub densities in milkvetch shrub communities; increased shrub densities increases the proximity of suitable host shrubs, which in turn increase the probability of successful seed dispersal and establishment

Mutational spectrum of autosomal recessive limb-girdle muscular dystrophies in a cohort of 112 Iranian patients and reporting of a possible founder effect

Background: Limb-girdle muscular dystrophies are a group of genetically heterogeneous diseases that are inherited in both autosomal dominant (LGMDD) and autosomal recessive forms (LGMDR), the latter is more common especially in populations with high consanguineous marriages like Iran. In the present study, we aimed to investigate the genetic basis of patients who are suspicious of being affected by LGMDR. DNA samples of 60 families suspected of LGMD were extracted from their whole blood. Four short tandem repeat (STR) markers for each candidate genes related to LGMD R1 (calpain3 related)- R6 (δ-sarcoglycan-related) were selected, and all these 24 STRs were applied in two sets of multiplex PCR. After autozygosity mapping, Sanger sequencing and variant analysis were done. Predicting identified variants' effect was performed using in-silico tools, and they were interpreted according to the American College of Medical Genomics and Genetics (ACMG) guideline. MLPA was used for those patients who had large deletions. Fresh muscle specimens were taken from subjects and were evaluated using the conventional panel of histochemical stains. Results: forty out of sixty families showed homozygote haplotypes in CAPN3, DYSF, SGCA, and SGCB genes. The exons and intron-exon boundaries of the relevant genes were sequenced and totally 38 mutations including CAPN3 (n = 15), DYSF (n = 9), SGCB (n = 11), and SGCA (n = 3) were identified. Five out of them were novel. The most prevalent form of LGMDs in our study was calpainopathy followed by sarcoglycanopathy in which beta-sarcoglycanopathy was the most common form amongst them. Exon 2 deletion in the SGCB gene was the most frequent mutation in this study. We also reported evidence of a possible founder effect in families with mutations in DYSF and SGCB genes. We also detected a large consanguineous family suffered from calpainopathy who showed allelic heterogeneity. Conclusions: This study can expand our knowledge about the genetic spectrum of LGMD in Iran, and also suggest the probable founder effects in some Iranian subpopulations which confirming it with more sample size can facilitate our genetic diagnosis and genetic counseling. © 2020 The Author(s)

Causes and risk factors of urinary incontinence: Avicenna's point of view vs. contemporary findings

Purpose: To extract the causes and risk factors of urinary incontinence from an old medical text by Avicenna entitled "Canon of Medicine" and comparing it with contemporary studies. Materials and Methods: In this study, etiology and risk factors of urinary incontinence were extracted from Avicenna's "Canon of Medicine". Commentaries written on this book and other old reliable medical texts about bladder and its diseases were also studied. Then the achieved information was compared with contemporary findings of published articles. Results: Urinary incontinence results from bladder dysfunction in reservoir phase. Bladder's involuntary muscles and voluntary external sphincter are two main components which are involved in this process. Urinary incontinence can exist without obvious structural and neuronal etiologies. According to Avicenna, distemperment of muscular tissue of bladder and external sphincter is the cause for urinary incontinence in such cases. Distemperment is the result of bothering qualities in tissue, i.e.: "wet" and "cold". They are the two bothering qualities which are caused by extracorporeal and intracorporeal factors. Interestingly, the positive associations of some of these factors with urinary incontinence have been shown in recent researches. Conclusion: "Cold" and "wet" distemperment of bladder and external sphincter can be independent etiologies of urinary incontinence which should be investigated

Rarity in Astragalus: a California Perspective

Astragalus (Fabaceae), the largest genus of plants in the world with an estimated 3270 species, is known for large numbers of rare endemic species. An inventory of patterns of climatic, topographic, and edaphic diversity of Astragalus taxa in California (98 native species and 144 named taxa) provides a means to understand the occurrence of rarity in relation to climatic equitability and regional species richness of congeneric taxa. Most taxa in the genus have relatively small ranges of distribution, with 50% restricted geographically to a single Jepson Bioregion. The California Native Plant Society lists 51 Astragalus taxa (35% of the native Astragalus taxa) as rare, threatened, or endangered (RTE). Climate characteristics of geographic regions such as rainfall and temperature extremes show no obvious relationship to species richness or the proportion of listed taxa. Species richness is highest in the arid Great Basin (35 species and 53 taxa) combining both its components, followed by 29 species and 39 taxa in the Sierra Nevada East region that includes the White and Inyo Mountains. The Mojave Desert is also high in diversity with 32 species and 39 taxa, but in contrast the Sonoran Desert region is low with only 12 species and 14 taxa. Despite ranking highest in the number of Astragalus taxa present, the Great Basin regions are low in their proportion of RTE taxa (17%) compared to the South Coast Region (39.5%) and Mojave Desert (32%). Strong edaphic specialization is associated with the majority but not all RTE taxa. While no single ecophysiological adaptation can explain this pattern, it is significant that Astragalus taxa have the potential ability to develop symbiotic nitrogen fixation, and this trait is key to success in soils not conducive to growth of many potential competitors. Land use changes, alien grass invasion and grazing, among other threats, are increasing fragmentation of habitats for many rare taxa with consequent impacts on gene flow. The continued survival of rare and locally endemic taxa will require improved knowledge of their individual demographic traits and long-term population dynamics