4 research outputs found
Palladium-Catalyzed Coupling of Alkynes with Unactivated Alkenes in Ionic Liquids: A Regio- and Stereoselective Synthesis of Functionalized 1,6-Dienes and Their Analogues
A palladium-catalyzed
regio- and stereoselective intermolecular
tandem reaction of alkynes and unactivated 1,6-enols in ionic liquids
is described, providing a practical, efficient, and versatile method
for the synthesis of functionalized 1,6-dienes in moderate to good
yields. The present reaction has high functional-group tolerance and
gives products on a gram scale. Mechanistic studies indicate that
the reaction might proceed via a chain-walking mechanism
Palladium-Catalyzed Tandem Annulation: A Strategy To Construct 2,3-Difunctionalized Benzofuran Derivatives in Ionic Liquids
An efficient and ecofriendly method
for the construction of 2,3-difunctionalized benzofuran derivatives
in moderate to good yields from readily available 2-alkynylphenols
has been developed. This tandem annulation process, featuring one
pot, three steps, good functional group tolerance, and high atom economy,
makes this transformation efficient and practical. Moreover, this
protocol is scalable, illustrating its potential applications in synthetic
and pharmaceutical chemistry
Assembly of 3‑Sulfenylbenzofurans and 3‑Sulfenylindoles by Palladium-Catalyzed Cascade Annulation/Arylthiolation Reaction
A novel
and efficient palladium-catalyzed cascade annulation/arylthiolation
reaction has been developed to afford functionalized 3-sulfenylbenzofuran
and 3-sulfenylindole derivatives in moderate to good yields from readily
available 2-alkynylphenols and 2-alkynylamines in ionic liquids. This
protocol provides a valuable synthetic tool for the assembly of a
wide range of 3-sulfenylbenzofuran and 3-sulfenylindole derivatives
with high atom- and step-economy and exceptional functional group
tolerance. Moreover, the employment of ionic liquids under mild reaction
conditions makes this transformation green and practical. Furthermore,
this approach enriched current C–S bond formation chemistry,
making a valuable and practical method in synthetic and medicinal
chemistry
Direct Assembly of 4‑Substituted Quinolines with Vinyl Azides as a Dual Synthon via CC and C–N Bond Cleavage
An unprecedented
Zn-promoted selective cleavage of vinyl azides
for the synthesis of 4-substituted quinolines is developed. In this
conversion, vinyl azides function as a dual synthon via Cî—»C
and C–N bond cleavage with two CC bonds and one CN
bond formation in a one-step manner. The reaction is appreciated for
its readily accessible substrates, high step economy, mild conditions,
and use of air as the sole oxidant