Palladium-Catalyzed Coupling
of Alkynes with Unactivated
Alkenes in Ionic Liquids: A Regio- and Stereoselective Synthesis of
Functionalized 1,6-Dienes and Their Analogues
- Publication date
- Publisher
Abstract
A palladium-catalyzed
regio- and stereoselective intermolecular
tandem reaction of alkynes and unactivated 1,6-enols in ionic liquids
is described, providing a practical, efficient, and versatile method
for the synthesis of functionalized 1,6-dienes in moderate to good
yields. The present reaction has high functional-group tolerance and
gives products on a gram scale. Mechanistic studies indicate that
the reaction might proceed via a chain-walking mechanism
