Does judicial foreclosure procedure help delinquent subprime mortgage borrowers?

We conduct comprehensive analyses on whether and how the judicial foreclosure procedure helps subprime mortgage borrowers to reinstate their delinquent loans outside foreclosure liquidation. Even though the transition rates of various exit types are all higher in non-judicial states, we argue such higher rates can be mechanically driven by the faster shrinking pool of delinquent mortgages in non-judicial states over time. Based on the cumulative proportions of various exit types during a period of up to 5 years post the mortgage first become 90 days past due, we find that judicial states offer more opportunities for delinquent borrowers to reinstate their loans outside foreclosure liquidation, especially during a housing market downturn. Cures, modifications, and paid-offs were all important alternative ways to resolve serious delinquencies during 2007–2008. After modifications became widely available in 2009, loan modifications became the most important alternative for subprime borrowers to reinstate their delinquent mortgages outside foreclosure liquidation. The lion\u27s share of the judicial foreclosure benefit shows up after the start of the foreclosure process

High Level of CXCR4 in Triple-Negative Breast Cancer Specimens Associated with a Poor Clinical Outcome

Despite high sensitivity to chemotherapy, the prognosis for triple-negative breast cancer (TNBC) remains poor because of its high rate of metastasis and low sensitivity to endocrine therapy. CXCR4 expression has been reported in many subtypes of human breast cancers, but it remains unknown whether CXCR4 is expressed in TNBC and whether CXCR4 expression in TNBC could be a prognostic indicator. TNBCs tissues were formalin fixed, paraffin embedded and hematoxylin-eosin (H&E) stained. Immunohistochemical staining was utilized to determine the CXCR4 expression in those specimens. Statistical analyses were performed using SPSS16.0 software to reveal the correlation of CXCR4 expression in TNBC specimens and cancer recurrence and cancer-related death. Our results showed that there was a strong association between CXCR4 overexpression and both menopause and the histological cancer grade of TNBC patients (p values were separately 0.004 and 0.001). The 5-y disease-free survival (DFS) and the 5-y overall survival (OS) were 57.69% and 58.33% for the low-CXCR4 group versus 42.11% and 44.74% for the high-CXCR4 group, respectively (p＝0.031 and 0.048). CXCR4 overexpression plays an important role in triple-negative breast cancers, and may be a predictor of poor prognosis

Effect of rotor magnetic isolation dimensions on no‐load performance of ultra‐low speed high torque spoke type permanent magnet motor

Abstract This study investigates the effects of rotor magnetic isolation dimensions on the no‐load performance of ultra‐low speed high torque spoke type permanent magnet motor. The studied spoke type permanent magnet motor structures are shown, where the rotor magnetic isolation parts include a magnetic barrier near the air gap (MB‐NAG), a magnetic barrier near the magnetic isolation sleeve (MB‐NMIS), a magnetic isolation sleeve (MIS). The magnetic circuit model is performed and the finite element analysis method is used to analyse the no‐load performance. Through analysing no‐load performance with three MB‐NAG shapes, the way to narrow the optimise dimension range considering reducing the cogging torque and increasing the back‐EMF synchronously is concluded. The results with different MB‐NMIS and MIS dimensions show that: (a) the optimised MB‐NMIS dimensions can increase the back‐EMF with a thin MIS in a certain dimension range of MB‐NMIS, and (b) the increasing proportion of back‐EMF influenced by the MB‐NMIS is inversely proportional to the thickness of MIS. The feasibility and effectiveness of the proposed motor structure and conclusion are experimentally verified

Polyaniline Functionalized Peptide Self-Assembled Conductive Hydrogel for 3D Cell Culture

The functionalization of self-assembled peptide hydrogel is of great importance to broaden its applications in the field of biomedicine. In this work, conductive hydrogel is fabricated by introducing conductive polymer polyaniline into peptide self-assembled hydrogel. Compared with pure peptide formed hydrogel, the conductive hydrogel exhibits enhanced conductivity, mechanical property and stability. In addition, the hydrogel is tested to be of great injectability and 3D bio-printability and could support the viability of encapsulated cells that are sensitive to electrical signals. It should have great application prospects in the preparation of tissue engineering scaffolds

Polyaniline Functionalized Peptide Self-Assembled Conductive Hydrogel for 3D Cell Culture

The functionalization of self-assembled peptide hydrogel is of great importance to broaden its applications in the field of biomedicine. In this work, conductive hydrogel is fabricated by introducing conductive polymer polyaniline into peptide self-assembled hydrogel. Compared with pure peptide formed hydrogel, the conductive hydrogel exhibits enhanced conductivity, mechanical property and stability. In addition, the hydrogel is tested to be of great injectability and 3D bio-printability and could support the viability of encapsulated cells that are sensitive to electrical signals. It should have great application prospects in the preparation of tissue engineering scaffolds

ReBiDet: An Enhanced Ship Detection Model Utilizing ReDet and Bi-Directional Feature Fusion

To enhance ship detection accuracy in the presence of complex scenes and significant variations in object scales, this study introduces three enhancements to ReDet, resulting in a more powerful ship detection model called rotation-equivariant bidirectional feature fusion detector (ReBiDet). Firstly, the feature pyramid network (FPN) structure in ReDet is substituted with a rotation-equivariant bidirectional feature fusion feature pyramid network (ReBiFPN) to effectively capture and enrich multiscale feature information. Secondly, K-means clustering is utilized to group the aspect ratios of ground truth boxes in the dataset and adjust the anchor size settings accordingly. Lastly, the difficult positive reinforcement learning (DPRL) sampler is employed instead of the random sampler to address the scale imbalance issue between objects and backgrounds in the dataset, enabling the model to prioritize challenging positive examples. Through numerous experiments conducted on the HRSC2016 and DOTA remote sensing image datasets, the effectiveness of the proposed improvements in handling complex environments and small object detection tasks is validated. The ReBiDet model demonstrates state-of-the-art performance in remote sensing object detection tasks. Compared to the ReDet model and other advanced models, our ReBiDet achieves mAP improvements of 3.20, 0.42, and 1.16 on HRSC2016, DOTA-v1.0, and DOTA-v1.5, respectively, with only a slight increase of 0.82 million computational parameters

Polyaniline Functionalized Peptide Self-Assembled Conductive Hydrogel for 3D Cell Culture

The functionalization of self-assembled peptide hydrogel is of great importance to broaden its applications in the field of biomedicine. In this work, conductive hydrogel is fabricated by introducing conductive polymer polyaniline into peptide self-assembled hydrogel. Compared with pure peptide formed hydrogel, the conductive hydrogel exhibits enhanced conductivity, mechanical property and stability. In addition, the hydrogel is tested to be of great injectability and 3D bio-printability and could support the viability of encapsulated cells that are sensitive to electrical signals. It should have great application prospects in the preparation of tissue engineering scaffolds

Efficient recombinant production of mouse-derived cryptdin family peptides by a novel facilitation strategy for inclusion body formation

Abstract Background A number of antimicrobial peptides (AMPs) hold promise as new drugs owing to their potent bactericidal activity and because they are often refractory to the development of drug resistance. Cryptdins (Crps) are a family of antimicrobial peptides found in the small intestine of mice, comprising six isoforms containing three sets of disulfide bonds. Although Crp4 is actively being investigated, there have been few studies to date on the other Crp isoforms. A prerequisite for detailed characterization of the other Crp isoforms is establishment of efficient sample preparation methods. Results To avoid degradation during recombinant expression of Crps in E. coli, co-expression of Crps with the aggregation-prone protein human α-lactalbumin (HLA) was used to promote the formation of stable inclusion bodies. Using this method, the production of Crp4 and Crp6 by the BL21 strain was effective, but the expression of other Crp isoforms was not as efficient. The results of a cell-free system study suggested that Crps were degraded, even though a substantial amounts of Crps were synthesized. Therefore, using the Origami™ B strain, we were able to significantly increase the expression efficiency of Crps by promoting the formation of erroneous intermolecular disulfide bonds between HLA and Crps, thereby promoting protein aggregation and inclusion body formation, which prevented degradation. The various Crp isoforms were successfully refolded in vitro and purified using reversed-phase HPLC. In addition, the yield was further improved by deformylation of formyl-Crps. We measured the antibacterial activity of Crps against both Gram-positive and Gram-negative bacteria. Each Crp isoform exhibited a completely different trend in antimicrobial activity, although conformational analysis by circular dichroism did not reveal any significant steric differences. Conclusion In this study, we established a novel and efficient method for the production of the cryptdin family of cysteine-containing antimicrobial peptides. Additionally, we found that there were notable differences in the antibacterial activities of the various Crp family members. The expression system established in this study is expected to provide new insights regarding the mechanisms underlying the different antibacterial activities of the Crp family of peptides