Moderating Effects of Information-Oriented versus Escapism-Oriented Motivations on the Relationship Between Psychological Well-Being and Problematic Use of Video Game Live-Streaming services

Background and aims: Video game live-streaming platforms are widely used by gamers. However, the excessive use of such services has rarely been examined. Although psychosocial well-being and motivations for use have been demonstrated to play major roles in online addiction, understanding the moderating mechanism of these two factors is warranted. Video game live-streaming platforms are an ideal context for studying the moderating role of both informational and escapism motivations, because viewers on such platforms can learn gaming strategies or escape from the reality. Methods: This study collected survey data from 508 users of the highly popular game-streaming service Twitch. The sample was divided into two groups based on the respondents’ use motivations. Regression models with interaction terms were fitted, followed by a simple slope test, to verify the hypotheses. Results: For the escapism-oriented group, a moderating effect of escapism on the relationship between loneliness and negative outcomes was found; the relationship was positive for low and moderate levels of escapism, but it was non-significant for individuals with high levels of escapism. For the information-oriented group, information seeking was observed to exert a moderating effect on the relationship between stress and negative outcomes; the relationship was negative for low and moderate levels of information seeking, but it was non-significant for individuals demonstrating high levels of information seeking. Discussion and conclusions: The findings promote understanding regarding how individuals using similar Internet-related coping strategies to deal with problems differ in their propensity for experiencing negative consequences when motivation levels and online environments are considered

Little String Amplitudes (and the Unreasonable Effectiveness of 6D SYM)

We study tree level scattering amplitudes of four massless states in the double scaled little string theory, and compare them to perturbative loop amplitudes in six-dimensional super-Yang-Mills theory. The little string amplitudes are computed from correlators in the cigar coset CFT and in N=2 minimal models. The results are expressed in terms of integrals of conformal blocks and evaluated numerically in the alpha' expansion. We find striking agreements with up to 2-loop scattering amplitudes of massless gluons in 6D SU(k) SYM at a Z_k invariant point on the Coulomb branch. We comment on the issue of UV divergence at higher loop orders in the gauge theory and discuss the implication of our results.Comment: 58 pages, 5 figures, 3 tables, comments added, references adde

Topological Defect Lines and Renormalization Group Flows in Two Dimensions

We consider topological defect lines (TDLs) in two-dimensional conformal field theories. Generalizing and encompassing both global symmetries and Verlinde lines, TDLs together with their attached defect operators provide models of fusion categories without braiding. We study the crossing relations of TDLs, discuss their relation to the 't Hooft anomaly, and use them to constrain renormalization group flows to either conformal critical points or topological quantum field theories (TQFTs). We show that if certain non-invertible TDLs are preserved along a RG flow, then the vacuum cannot be a non-degenerate gapped state. For various massive flows, we determine the infrared TQFTs completely from the consideration of TDLs together with modular invariance.Comment: 101 pages, 63 figures, 2 tables; v3: minor changes, added footnotes and references, published versio

Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery.

Neurite initiation is the first step in neuronal development and occurs spontaneously in soft tissue environments. Although the mechanisms regulating the morphology of migratory cells on rigid substrates in cell culture are widely known, how soft environments modulate neurite initiation remains elusive. Using hydrogel cultures, pharmacologic inhibition, and genetic approaches, we reveal that paxillin-linked endocytosis and adhesion are components of a bistable switch controlling neurite initiation in a substrate modulus-dependent manner. On soft substrates, most paxillin binds to endocytic factors and facilitates vesicle invagination, elevating neuritogenic Rac1 activity and expression of genes encoding the endocytic machinery. By contrast, on rigid substrates, cells develop extensive adhesions, increase RhoA activity and sequester paxillin from the endocytic machinery, thereby delaying neurite initiation. Our results highlight paxillin as a core molecule in substrate modulus-controlled morphogenesis and define a mechanism whereby neuronal cells respond to environments exhibiting varying mechanical properties

3d N=4 Bootstrap and Mirror Symmetry

We investigate the non-BPS realm of 3d ${\cal N} = 4$ superconformal field theory by uniting the non-perturbative methods of the conformal bootstrap and supersymmetric localization, and utilizing special features of 3d ${\cal N} = 4$ theories such as mirror symmetry and a protected sector described by topological quantum mechanics (TQM). Supersymmetric localization allows for the exact determination of the conformal and flavor central charges, and the latter can be fed into the mini-bootstrap of the TQM to solve for a subset of the OPE data. We examine the implications of the $\mathbb{Z}_2$ mirror action for the SCFT single- and mixed-branch crossing equations for the moment map operators, and apply numerical bootstrap to obtain universal constraints on OPE data for given flavor symmetry groups. A key ingredient in applying the bootstrap analysis is the determination of the mixed-branch superconformal blocks. Among other results, we show that the simplest known self-mirror theory with $SU(2) \times SU(2)$ flavor symmetry saturates our bootstrap bounds, which allows us to extract the non-BPS data and examine the self-mirror $\mathbb{Z}_2$ symmetry thereof

Arctigenin from Arctium lappa inhibits interleukin-2 and interferon gene expression in primary human T lymphocytes

<p>Abstract</p> <p>Background</p> <p><it>Arctium lappa </it>(<it>Niubang</it>), a Chinese herbal medicine, is used to treat tissue inflammation. This study investigates the effects of arctigenin (AC), isolated from <it>A. lappa</it>, on anti-CD3/CD28 Ab-stimulated cell proliferation and cytokine gene expression in primary human T lymphocytes.</p> <p>Methods</p> <p>Cell proliferation was determined with enzyme immunoassays and the tritiated thymidine uptake method. Cytokine production and gene expression were analyzed with reverse transcription-polymerase chain reaction.</p> <p>Results</p> <p>AC inhibited primary human T lymphocytes proliferation activated by anti-CD3/CD28 Ab. Cell viability test indicated that the inhibitory effects of AC on primary human T lymphocyte proliferation were not due to direct cytotoxicity. AC suppressed interleukin-2 (IL-2) and interferon-γ (IFN-γ) production in a concentration-dependent manner. Furthermore, AC decreased the IL-2 and IFN-γ gene expression in primary human T lymphocytes induced by anti-CD3/CD28 Ab. Reporter gene analyses revealed that AC decreased NF-AT-mediated reporter gene expression.</p> <p>Conclusion</p> <p>AC inhibited T lymphocyte proliferation and decreased the gene expression of IL-2, IFN-γ and NF-AT.</p

Genetic analysis of fish iridoviruses isolated in Taiwan during 2001–2009

To investigate the genetic relationships between field strains of iridoviruses gathered from various fish species in Taiwan, viruses that were collected from 2001 to 2009 were analyzed. Open reading frames encoding the viral major capsid protein (MCP) and adenosine triphosphatase (ATPase) were sequenced for phylogenetic analysis. Our results indicated that iridoviruses from Taiwan aquaculture fishes could be classified into two groups: prior to 2005, the viruses were closely related to members of the genus Ranavirus; and after 2005, they were similar to members of the genus Megalocytivirus. Based on the analysis of MCP amino acid sequences, virus isolates were divided into 4 major genotypes that were related to ISKNV, RSIV, FLIV, and GIV, respectively. Pairwise comparisons of MCP genes showed that the ranavirus was an epidemic pathogen for economically important species in the major production regions and cultured marine fish, while the megalocytivirus isolates were sensitive to host range. In addition, the distribution of synonymous and non-synonymous changes in the MCP gene revealed that the iridoviruses were evolving slowly, and most of the variations were synonymous mutations. The Ka/Ks values were lower than one, and hence, the viruses were under negative selection

Topological Defect Lines and Renormalization Group Flows in Two Dimensions

We consider topological defect lines (TDLs) in two-dimensional conformal field theories. Generalizing and encompassing both global symmetries and Verlinde lines, TDLs together with their attached defect operators provide models of fusion categories without braiding. We study the crossing relations of TDLs, discuss their relation to the ’t Hooft anomaly, and use them to constrain renormalization group flows to either conformal critical points or topological quantum field theories (TQFTs). We show that if certain non-invertible TDLs are preserved along a RG flow, then the vacuum cannot be a non-degenerate gapped state. For various massive flows, we determine the infrared TQFTs completely from the consideration of TDLs together with modular invariance