ALTERNATIVES FOR FINANCING MUNICIPAL SERVICES: THE CASE OF UNIT-PRICED TRASH DISPOSAL

New policy is being developed that incorporates not only innovative means of disposal, including the integration of source reduction and recycling, but also innovative approaches to funding disposal of municipal solid waste (MSW). This study was conducted to determine if a higher marginal price for MSW disposal affected per capita waste generation in New Hampshire towns, how the existence of a pay-as-you-throw (PAYT) program influenced per capita MSW generation, and to attempt to determine which towns were most likely to adopt a PAYT program in the future. The results showed that average household size, existence of a capital improvement plan, and marginal price to dispose of waste were statistically significant influences, regardless of the variation of price in the PAYT program. Towns with PAYT programs currently being implemented produce 0.18 tons of MSW less waste per capita per year than towns without PAYT programs.Public Economics,

Biomedical Engineering Students’ Perceived Learning Through Co-Curriculars

Background: Co-curricular student outcomes research has focused on connecting outcomes to activities based on the co-curricular type. Less work has explored what aspects of those co-curricular activities could lead to student outcomes. Purpose: Our research aimed to identify common elements of co-curricular activities that connected to students’ development of professional, career, or personal outcomes and can inform how we study and design co-curricular activities in engineering. Design: We recruited participants from one biomedical engineering (BME) program. We used a one-year series of four semi-structured interviews with fourteen upper-level BME students to explore students’ perceptions of their co-curricular learning. Using a qualitative, causal analysis approach, we identified elements of students’ co-curricular experiences in research or a multi-disciplinary design team, as well as other co-curricular experiences (e.g., internships, professional societies), that linked to professional, career, or personal learning outcomes that have been previously identified as important in engineering education. Findings: We identified patterns of connections between unique “experience elements” and a variety of “outcome categories” through participant activities we called “participant actions.” The most prevalent connections—those experience elements and participant actions that connected to multiple outcome categories—included the experience elements Independent Project Work, Project Work That Engages Multiple Disciplines, STEM Education Opportunities, and Mentorship from a Skilled Other as well as a participant action Reflecting on Experience. We found connections to the outcome categories of Leadership, Design, Business, Interdisciplinary Competence, Disciplinary Competence, Communication, and Career Direction Outcomes. Conclusions: Based on our findings, educators and mentors should consider the value of supporting students’ decision-making autonomy and multidisciplinary interactions in projects to support learning. They could also incorporate opportunities for students to teach each other technical content, receive structured mentorship, and reflect on their experiences as they are happening. Further, this work demonstrates a need to explore co-curricular learning processes in new ways that can lead to better understandings of students’ learning processes

Visualizing Hypothalamic Network Dynamics for Appetitive and Consummatory Behaviors

Optimally orchestrating complex behavioral states such as the pursuit and consumption of food is critical for an organism’s survival. The lateral hypothalamus (LH) is a neuroanatomical region essential for appetitive and consummatory behaviors, but whether individual neurons within the LH differentially contribute to these interconnected processes is unknown. Here we show that selective optogenetic stimulation of a molecularly defined subset of LH GABAergic (Vgat-expressing) neurons enhances both appetitive and consummatory behaviors, while genetic ablation of these neurons reduced these phenotypes. Furthermore, this targeted LH subpopulation is distinct from cells containing the feeding-related neuropeptides, melanin-concentrating hormone (MCH) and orexin (Orx). Employing in vivo calcium imaging in freely behaving mice, to record activity dynamics from hundreds of cells, we identified individual LH GABAergic neurons that preferentially encode aspects of either appetitive or consummatory behaviors, but rarely both. These tightly regulated, yet highly intertwined, behavioral processes are thus dissociable at the cellular level

Visualizing Hypothalamic Network Dynamics for Appetitive and Consummatory Behaviors

Optimally orchestrating complex behavioral states such as the pursuit and consumption of food is critical for an organism’s survival. The lateral hypothalamus (LH) is a neuroanatomical region essential for appetitive and consummatory behaviors, but whether individual neurons within the LH differentially contribute to these interconnected processes is unknown. Here we show that selective optogenetic stimulation of a molecularly defined subset of LH GABAergic (Vgat-expressing) neurons enhances both appetitive and consummatory behaviors, while genetic ablation of these neurons reduced these phenotypes. Furthermore, this targeted LH subpopulation is distinct from cells containing the feeding-related neuropeptides, melanin-concentrating hormone (MCH) and orexin (Orx). Employing in vivo calcium imaging in freely behaving mice, to record activity dynamics from hundreds of cells, we identified individual LH GABAergic neurons that preferentially encode aspects of either appetitive or consummatory behaviors, but rarely both. These tightly regulated, yet highly intertwined, behavioral processes are thus dissociable at the cellular level

SPARC: a matricellular regulator of tumorigenesis

Although many clinical studies have found a correlation of SPARC expression with malignant progression and patient survival, the mechanisms for SPARC function in tumorigenesis and metastasis remain elusive. The activity of SPARC is context- and cell-type-dependent, which is highlighted by the fact that SPARC has shown seemingly contradictory effects on tumor progression in both clinical correlative studies and in animal models. The capacity of SPARC to dictate tumorigenic phenotype has been attributed to its effects on the bioavailability and signaling of integrins and growth factors/chemokines. These molecular pathways contribute to many physiological events affecting malignant progression, including extracellular matrix remodeling, angiogenesis, immune modulation and metastasis. Given that SPARC is credited with such varied activities, this review presents a comprehensive account of the divergent effects of SPARC in human cancers and mouse models, as well as a description of the potential mechanisms by which SPARC mediates these effects. We aim to provide insight into how a matricellular protein such as SPARC might generate paradoxical, yet relevant, tumor outcomes in order to unify an apparently incongruent collection of scientific literature

Analyzing Unit Pricing of Waste Management Using Treatment Effects Models

Q00, R10,

Managing Municipal Solid Waste with Unit-Based Pricing: Policy Effects and Responsiveness to Pricing

Many municipalities across the United States have turned to unit based pricing-also known as pay as you throw (PAYT)-as a vehicle for reducing municipal solid waste generation, increasing recycling, and promoting equity in paying for the service. In this paper we reevaluate the standard analytical methods used to examine the impact of PAYT in he literature and illustrate that econometric shortcomings may have led to underestimation of policy effects. A two-tier analytical approach to examining PAYT program effects is proposed and is demonstrated in a case study of New Hampshire municipalities. (JEL O18, Q58

ALTERNATIVES FOR FINANCING MUNICIPAL SERVICES: THE CASE OF UNIT-PRICED TRASH DISPOSAL

New policy is being developed that incorporates not only innovative means of disposal, including the integration of source reduction and recycling, but also innovative approaches to funding disposal of municipal solid waste (MSW). This study was conducted to determine if a higher marginal price for MSW disposal affected per capita waste generation in New Hampshire towns, how the existence of a pay-as-you-throw (PAYT) program influenced per capita MSW generation, and to attempt to determine which towns were most likely to adopt a PAYT program in the future. The results showed that average household size, existence of a capital improvement plan, and marginal price to dispose of waste were statistically significant influences, regardless of the variation of price in the PAYT program. Towns with PAYT programs currently being implemented produce 0.18 tons of MSW less waste per capita per year than towns without PAYT programs

Managing Municipal Solid Waste with Unit-Based Pricing: Policy Effects and Responsiveness to Pricing

Many municipalities across the United States have turned to unit based pricing—also known as pay as you throw (PAYT)—as a vehicle for reducing municipal solid waste generation, increasing recycling, and promoting equity in paying for the service. In this paper, we reevaluate the standard analytical methods used to examine the impact of PAYT in the literature and illustrate that econometric shortcomings may have led to underestimation of policy effects. A two-tier analytical approach to examining PAYT program effects is proposed and is demonstrated in a case study of New Hampshire municipalities.