The Numerical Simulation of the Airflow Distribution and Energy Efficiency in Data Centers with Three Types of Aisle Layout

The energy consumption of fast-growing data centers is drawing attentions from not only energy organizations and institutions all over the world, but also charity groups, such as Greenpeace, and research shows that the power consumption of air conditioning makes up a large proportion of the electricity cost in data centers. Therefore, more detailed investigations of air conditioning power consumption are warranted. Three types of airflow distributions with different aisle layouts (the open aisle, the closed cold aisle, and the closed hot aisle) were investigated with Computational Fluid Dynamics (CFD) methods in a typical data center of four rows of racks in this study. To evaluate the results of thermal and bypass phenomenon, the temperature increase index (β) and the energy utilization index (ηr) were used. The simulations show that there is a better trend of the β index and ηr index both closed cold aisle and closed hot aisle compared with free open aisle. Especially with high air flow rate, the β index decreases and the ηr index increases considerably. Moreover, the results prove the closed aisles (both closed cold aisle and closed hot aisle) can not only significantly improve the airflow distribution, but also reduce the mixture of cold and heat flow, and therefore improve energy efficiency. In addition, it proves the design of the closed aisles can meet the increasing density of installations and our simulation method could evaluate the cooling capacity easily

circSLC4A7 accelerates stemness and progression of gastric cancer by interacting with HSP90 to activate NOTCH1 signaling pathway

Abstract Gastric cancer stem cells (GCSCs) play critical roles in gastric cancer (GC) initiation and development. Circular RNAs (circRNAs) participate in diverse cancer biological processes and function as tumor suppressors or oncogenes. This study aims to discover the expression profile and functional roles of circRNAs in GCSCs. A spheroid formation assay was conducted to enrich GCSCs. Genome-wide sequencing of circRNAs showed that a novel circRNA, circSLC4A7, was one of the most upregulated circRNAs in GCSCs. CircSLC4A7 was localized to the nucleus, and its level was elevated in GC cells and tissues. Furthermore, circSLC4A7 increased CSC-like properties and drove cell proliferation, migration, and invasion, which were determined by gain- and loss-of-function experiments. Specific circRNA pull-down assays followed by mass spectrometry analysis, RNA immunoprecipitation, and dual RNA-fluorescence in situ hybridization and immunofluorescence assay were conducted and HSP90 was detected to interact with circSLC4A7 and mediate the oncogenic function of circSLC4A7 by activating the Notch1 signaling pathway in GC. This study highlights a novel oncogenic function of circSLC4A7 mediated by its binding with HSP90 and thus activating the Notch1 signaling pathway

Effects of the Microbubble Generation Mode on Hydrodynamic Parameters in Gas–Liquid Bubble Columns

The hydrodynamics parameters of microbubbles in a bubble column were studied in an air–water system with a range of superficial gas velocity from 0.013 to 0.100 m/s using a differential pressure transmitter, double probe optical fiber probe, and electrical resistance tomography (ERT) technique. Two kinds of microbubble generators (foam gun, sintered plate) were used to generate microbubbles in the bubble column with a diameter of 90 mm, and to compare the effects of different foaming methods on the hydrodynamics parameters in the bubble column. The hydrodynamic behavior of the homogeneous regime and the transition regime was also studied. The results show that, by changing the microbubble-generating device, the hydrodynamic parameters in the column are changed, and both microbubble-generating devices can obtain a higher gas holdup and a narrower chord length distribution. When the foam gun is used as the gas distributor, a higher gas holdup and a narrower average bubble chord length can be obtained than when the sintered plate is used as the gas distributor. In addition, under different operating conditions, the relative frequency distribution of the chord length at different radial positions is mainly concentrated in the interval of 0–5 mm, and it is the highest in the center of the column