A methodology for full-system power modeling in heterogeneous data centers

The need for energy-awareness in current data centers has encouraged the use of power modeling to estimate their power consumption. However, existing models present noticeable limitations, which make them application-dependent, platform-dependent, inaccurate, or computationally complex. In this paper, we propose a platform-and application-agnostic methodology for full-system power modeling in heterogeneous data centers that overcomes those limitations. It derives a single model per platform, which works with high accuracy for heterogeneous applications with different patterns of resource usage and energy consumption, by systematically selecting a minimum set of resource usage indicators and extracting complex relations among them that capture the impact on energy consumption of all the resources in the system. We demonstrate our methodology by generating power models for heterogeneous platforms with very different power consumption profiles. Our validation experiments with real Cloud applications show that such models provide high accuracy (around 5% of average estimation error).This work is supported by the Spanish Ministry of Economy and Competitiveness under contract TIN2015-65316-P, by the Gener- alitat de Catalunya under contract 2014-SGR-1051, and by the European Commission under FP7-SMARTCITIES-2013 contract 608679 (RenewIT) and FP7-ICT-2013-10 contracts 610874 (AS- CETiC) and 610456 (EuroServer).Peer ReviewedPostprint (author's final draft

The product of the pilQ gene is essential for the biogenesis of type IV pili in Neisseria gonorrhoeae

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73956/1/j.1365-2958.1995.18050975.x.pd

Energy-Aware Cloud Management through Progressive SLA Specification

Novel energy-aware cloud management methods dynamically reallocate computation across geographically distributed data centers to leverage regional electricity price and temperature differences. As a result, a managed VM may suffer occasional downtimes. Current cloud providers only offer high availability VMs, without enough flexibility to apply such energy-aware management. In this paper we show how to analyse past traces of dynamic cloud management actions based on electricity prices and temperatures to estimate VM availability and price values. We propose a novel SLA specification approach for offering VMs with different availability and price values guaranteed over multiple SLAs to enable flexible energy-aware cloud management. We determine the optimal number of such SLAs as well as their availability and price guaranteed values. We evaluate our approach in a user SLA selection simulation using Wikipedia and Grid'5000 workloads. The results show higher customer conversion and 39% average energy savings per VM.Comment: 14 pages, conferenc

A reply to “Historical construction costs of global nuclear power reactors”

Lovering et al. (2016) present data on the overnight costs of more than half of nuclear reactors built worldwide since the beginning of the nuclear age. The authors claim that this consolidated data set offers more accurate insights than previous country-level assessments. Unfortunately, the authors make analytical choices that mask nuclear power's real construction costs, cherry pick data, and include misleading data on early experimental and demonstration reactors. For those reasons, serious students of such issues should look elsewhere for guidance about understanding the true costs of nuclear power

Pilin expression and processing in pilus mutants of Neisseria gonorrhoeae : critical role of Gly -1 in assembly

Spontaneous mutants of Neisseria gonorrheae failing to express pili or having diminished levels of piliation were studied with regard to pilin expression. All mutants displayed altered pilin processing detectable as the release of soluble, truncated pilin molecules (S-pilin). Of particular interest was the finding, in one mutant, that substitution of serine for glycine at position -1 of propilin, a highly conserved residue among N -metPhe and related pilins, abolished pilus expression but not S-pilin release. The degree of S-pilin processing and the levels of membrane-associated pilin varied among the different classes of mutants, suggesting that each was blocked at a distinct step of pilus biogenesis. The data support a model in which increased S-pilin processing is a result of a decreased rate of pilus polymerization.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74951/1/j.1365-2958.1991.tb02108.x.pd

Know Your Oil: Creating A Global Oil-Climate Index

Oil is changing. Conventional oil resources are dwindling as tight oil, oil sands, heavy oils, and others emerge. Technological advances mean that these unconventional hydrocarbon deposits in once-unreachable areas are now viable resources. Meanwhile, scientific evidence is mounting that climate change is occurring, but the climate impacts of these new oils are not well understood. The Carnegie Endowment's Energy and Climate Program, Stanford University, and the University of Calgary have developed a first-of-itskind Oil-Climate Index (OCI) to compare these resources.The Oil-Climate Index (OCI) is a metric that takes into account the total life-cycle Greenhouse Gas (GHG) emissions of individual oils -- from upstream extraction to midstream refining to downstream end use. It offers a powerful, yet user-friendly, tool that allows investors, policymakers, industry, the public, and other stakeholders to compare crudes and assess their climate consequences both before development decisions are made as well as once operations are in progress. The Oil-Climate Index will also inform oil and climate policy making

Energy-Efficient Algorithms

We initiate the systematic study of the energy complexity of algorithms (in addition to time and space complexity) based on Landauer's Principle in physics, which gives a lower bound on the amount of energy a system must dissipate if it destroys information. We propose energy-aware variations of three standard models of computation: circuit RAM, word RAM, and transdichotomous RAM. On top of these models, we build familiar high-level primitives such as control logic, memory allocation, and garbage collection with zero energy complexity and only constant-factor overheads in space and time complexity, enabling simple expression of energy-efficient algorithms. We analyze several classic algorithms in our models and develop low-energy variations: comparison sort, insertion sort, counting sort, breadth-first search, Bellman-Ford, Floyd-Warshall, matrix all-pairs shortest paths, AVL trees, binary heaps, and dynamic arrays. We explore the time/space/energy trade-off and develop several general techniques for analyzing algorithms and reducing their energy complexity. These results lay a theoretical foundation for a new field of semi-reversible computing and provide a new framework for the investigation of algorithms.Comment: 40 pages, 8 pdf figures, full version of work published in ITCS 201

Down-regulation of CD46 by Piliated Neisseria gonorrhoeae

Human membrane cofactor protein (CD46) protects host cells against complement attack and may function as a receptor for pathogenic Neisseriae. We assessed CD46 expression in the human cervical cell line ME-180 after exposure to Neisseria gonorrhoeae. Piliated but not nonpiliated gonococci adhered to cells and produced up to an 80% reduction in CD46 surface expression by 6 h that persisted for at least 24 h. This response required a minimum multiplicity of infection of 10 and was not prevented by antibodies to CD46. CD46 down-regulation was not attributable to intracellular retention or a global or specific shutdown of mRNA or protein synthesis. Substantial quantities of CD46 were found in the supernatants, indicating a specific shedding of this protein. Adherent gonococci lacking the pilus retraction protein PilT did not down-regulate CD46 but de-repression of pilT expression restored CD46 down-regulation. After experimental infection of human volunteers with a gonococcal variant incapable of inducing CD46 down-regulation, variants of this strain were reisolated that exhibited CD46 down-regulation. Pilus-mediated interactions of gonococci with human epithelial cells results in a pathogen-induced manipulation of the host cell environment in which a membrane protein is removed from epithelial cells by liberation into the surrounding milieu

Single amino acid substitutions in the N-terminus of Vibrio cholerae TcpA affect colonization, autoagglutination, and serum resistance

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/74620/1/j.1365-2958.1995.mmi_17061133.x.pd