Diaqua­(5-carb­oxy­benzene-1,3-dicarboxyl­ato-κ2 O 1,O 1′)(6,6′-dimethyl-2,2′-bipyridine-κ2 N,N′)nickel(II) hepta­hydrate

In the title compound, [Ni(C9H4O6)(C12H12N2)(H2O)2]·7H2O, the NiII atom is six-coordinated by two O atoms from a chelating carboxyl­ate group of a 5-carb­oxy­benzene-1,3-dicarboxyl­ate ligand, two O atoms of two water mol­ecules and two N atoms from a 6,6′-dimethyl-2,2′-bipyridine ligand in a distorted octa­hedral geometry. The compound exhibits a three-dimensional supra­molecular structure composed of the complex mol­ecules and lattice water mol­ecules, which are linked together by inter­molecular O—H⋯O hydrogen bonds and partly overlapping π–π inter­actions between the pyridine and benzene rings [centroid–centroid distances = 3.922 (2) and 3.921 (2) Å]. One of the lattice water mol­ecules is disordered over two positions in an occupancy ratio of 0.521 (6):0.479 (6)

Diaqua­(5-carb­oxy­benzene-1,3-di­carboxyl­ato-κO 1)(4,4′-dimethyl-2,2′-bipyridine-κ2 N,N′)zinc

In the title compound, [Zn(C9H4O6)(C12H12N2)(H2O)2], the ZnII atom is five-coordinated by two N atoms from a 4,4′-dimethyl-2,2′-bipyridine ligand, one O atom from a 5-carb­oxy­benzene-1,3-dicarboxyl­ate ligand and two water mol­ecules in a distorted trigonal–bipyramidal geometry. The complex mol­ecules are linked by inter­molecular O—H⋯O hydrogen bonds and partly overlapping π–π inter­actions [centroid–centroid distance = 4.017 (2) Å] into a three-dimensional supra­molecular network

Poly[[hexa­aqua­bis­(μ3-benzene-1,3,5-tricarboxyl­ato-κ3 O 1:O 3:O 5)bis­(5,5′-dimethyl-2,2′-bipyridine-κ2 N,N′)trizinc] hexa­hydrate]

In the title compound, {[Zn3(C9H3O6)2(C12H12N2)2(H2O)6]·6H2O}n, one ZnII atom, lying on an inversion center, is six-coordinated by two O atoms from two benzene-1,3,5-tricarboxyl­ate (btc) ligands and four water mol­ecules in a distorted octa­hedral geometry. The other ZnII atom is five-coordinated by two N atoms from a 5,5′-dimethyl-2,2′-bipyridine (dmbpy) ligand, two O atoms from two btc ligands and one water mol­ecule in a distorted trigonal–bipyramidal geometry. The compound features a one-dimensional ladder structure, with windows of ca 10.245 (1) × 15.446 (2) Å. The ladders are linked together by inter­molecular O—H⋯O hydrogen bonds and π–π inter­actions between the benzene rings and between the pyridine rings [centroid-to-centroid distances 3.858 (2) and 3.911 (3) Å, respectively] to form a three-dimensional supra­molecular structure. One of the lattice water molecules is disordered over two positions in a 0.592:0.408 ratio

Evaluation of a GNSS for wave measurement and directional wave spectrum analysis

Wave buoys are important devices to monitor and analyze wave data for ocean and coastal engineering. A GNSS wave buoy is briefly introduced in the paper, which has high resolution to measure the buoy motion by vertical, north-south and west-east displacements and independent velocities in above three directions. Based on the displacements and velocities, statistical results, frequency spectra and directional spectra are analyzed, and results based on the displacements are compared with that from Waverider with a distance less than 6m deployed in the special sea water with the GNSS buoy. Wave profiles comparison show that GNSS buoy presented slightly large significant wave height and mean wave height due to its high sampling frequency, and resulted in smaller mean wave period than that from Waverider. Statisticaly, between the analyzing result of the GNSS and wave rider, the maximum error of wave height is about 5.5%; and the maximum difference of wave period is about 0.5s, when sampling frequency is similar. The energy spectra were basically consistent from these two devices. The peaks of directional spectra were similar but the spreading angle was smaller from GNSS. Results mean the GNSS device presents almost similar wave information to that from Waverider.</p

Evaluation of a GNSS for wave measurement and directional wave spectrum analysis

Wave buoys are important devices to monitor and analyze wave data for ocean and coastal engineering. A GNSS wave buoy is briefly introduced in the paper, which has high resolution to measure the buoy motion by vertical, north-south and west-east displacements and independent velocities in above three directions. Based on the displacements and velocities, statistical results, frequency spectra and directional spectra are analyzed, and results based on the displacements are compared with that from Waverider with a distance less than 6m deployed in the special sea water with the GNSS buoy. Wave profiles comparison show that GNSS buoy presented slightly large significant wave height and mean wave height due to its high sampling frequency, and resulted in smaller mean wave period than that from Waverider. Statisticaly, between the analyzing result of the GNSS and wave rider, the maximum error of wave height is about 5.5%; and the maximum difference of wave period is about 0.5s, when sampling frequency is similar. The energy spectra were basically consistent from these two devices. The peaks of directional spectra were similar but the spreading angle was smaller from GNSS. Results mean the GNSS device presents almost similar wave information to that from Waverider.</p

Poly[bis[μ-1,3-bis­(imidazol-1-ylmeth­yl)benzene-κ2 N 3:N 3′]bis­(nitrato-κO)cadmium]

A novel metal–organic framework based on 1,3-bis­(imidazol-1-ylmeth­yl)benzene (1,3-bimb), [Cd(NO3)2(C14H14N4)2]n, has been synthesized hydro­thermally. The structure exhibits a two-dimensional metal–organic (4,4)-net composed of CdII atoms and bimb ligands, and such layers are further joined through inter­layer C—H⋯O hydrogen bonds to generate a three-dimensional supra­molecular structure

An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer

Advanced prostate cancer displays conspicuous chromosomal instability and rampant copy number aberrations, yet the identity of functional drivers resident in many amplicons remain elusive. Here, we implemented a functional genomics approach to identify new oncogenes involved in prostate cancer progression. Through integrated analyses of focal amplicons in large prostate cancer genomic and transcriptomic datasets as well as genes upregulated in metastasis, 276 putative oncogenes were enlisted into an in vivo gain-of-function tumorigenesis screen. Among the top positive hits, we conducted an in-depth functional analysis on Pygopus family PHD finger 2 (PYGO2), located in the amplicon at 1q21.3. PYGO2 overexpression enhances primary tumor growth and local invasion to draining lymph nodes. Conversely, PYGO2 depletion inhibits prostate cancer cell invasion in vitro and progression of primary tumor and metastasis in vivo In clinical samples, PYGO2 upregulation associated with higher Gleason score and metastasis to lymph nodes and bone. Silencing PYGO2 expression in patient-derived xenograft models impairs tumor progression. Finally, PYGO2 is necessary to enhance the transcriptional activation in response to ligand-induced Wnt/β-catenin signaling. Together, our results indicate that PYGO2 functions as a driver oncogene in the 1q21.3 amplicon and may serve as a potential prognostic biomarker and therapeutic target for metastatic prostate cancer.Significance: Amplification/overexpression of PYGO2 may serve as a biomarker for prostate cancer progression and metastasis. Cancer Res; 78(14); 3823-33. ©2018 AACR

Incorporating productivity loss in health economic evaluations : a review of guidelines and practices worldwide for research agenda in China

Introduction: Productivity loss may contribute to a large proportion of costs of health conditions in an economic evaluation from a societal perspective, but there is currently a lack of methodological consensus on how productivity loss should be measured and valued. Despite the research progress surrounding this issue in other countries, it has been rarely discussed in China. Methods: We reviewed the official guidelines on economic evaluations in different countries and regions and screened the literature to summarise the extent to which productivity loss was incorporated in economic evaluations and the underlying methodological challenges. Results: A total of 48 guidelines from 46 countries/regions were included. Although 32 (67%) guidelines recommend excluding productivity loss in the base case analysis, 23 (48%) guidelines recommend including productivity loss in the base case or additional analyses. Through a review of systematic reviews and the economic evaluation studies included in these reviews, we found that the average probability of incorporating productivity loss in an economic evaluation was 10.2%. Among the economic evaluations (n=478) that explicitly considered productivity loss, most (n=455) considered losses from paid work, while only a few studies (n=23) considered unpaid work losses. Recognising the existing methodological challenges and the specific context of China, we proposed a practical research agenda and a disease list for progress on this topic, including the development of the disease list comprehensively consisting of health conditions where the productivity loss should be incorporated into economic evaluations. Conclusion: An increasing number of guidelines recommend the inclusion of productivity loss in the base case or additional analyses of economic evaluation. We optimistically expect that more Chinese researchers notice the importance of incorporating productivity loss in economic evaluations and anticipate guidelines that may be suitable for Chinese practitioners and decision-makers that facilitate the advancement of research on productivity loss measurement and valuation

Novel superconducting structures of BH2 under high pressure

The crystal structures of boron hydrides in a pressure range of 50–400 GPa were studied using the genetic algorithm (GA) method combined with first-principles density functional theory calculations. BH4 and BH5 are predicted to be thermodynamically unstable. Two new BH2 structures with Cmcm and C2/c space group symmetries, respectively, were predicted, in which the B atoms tend to form two-dimensional sheets. The calculated band structures showed that in the pressure range of 50–150 GPa, the Cmcm-BH2 phase has very small gaps, while the C2/c-BH2 phase at 200–400 GPa is metallic. The superconductivity of the C2/c-BH2 structure was also investigated, and electron–phonon coupling calculations revealed that the estimated Tc values of C2/c-BH2 are about 28.18–37.31 K at 250 GPa