Vision of Death in Ionesco's Bérenger Cycle

Additional file 6: Figure S6. Dox itself has no effect on the expression of miR-690. Real-time qPCR results of miR-690 in Dox-treated C2C12/vectorDox cells. Data are presented as mean ± SD (n = 3)

3D Printing Drug-Free Scaffold with Triple-Effect Combination Induced by Copper-Doped Layered Double Hydroxides for the Treatment of Bone Defects

Tissue-engineered poly­(l-lactide) (PLLA) scaffolds have been widely used to treat bone defects; however, poor biological activities have always been key challenges for its further application. To address this issue, introducing bioactive drugs or factors is the most commonly used method, but there are often many problems such as high cost, uncontrollable and monotonous drug activity, and poor bioavailability. Here, a drug-free 3D printing PLLA scaffold with a triple-effect combination induced by surface-modified copper-doped layered double hydroxides (Cu-LDHs) is proposed. In the early stage of scaffold implantation, Cu-LDHs exert a photothermal therapy (PTT) effect to generate high temperature to effectively prevent bacterial infection. In the later stage, Cu-LDHs can further have a mild hyperthermia (MHT) effect to stimulate angiogenesis and osteogenic differentiation, demonstrating excellent vascularization and osteogenic activity. More importantly, with the degradation of Cu-LDHs, the released Cu2+ and Mg2+ provide an ion microenvironment effect and further synergize with the MHT effect to stimulate angiogenesis and osteogenic differentiation, thus more effectively promoting the healing of bone tissue. This triple-effect combined scaffold exhibits outstanding antibacterial, osteogenic, and angiogenic activities, as well as the advantages of low cost, convenient procedure, and long-term efficacy, and is expected to provide a promising strategy for clinical repair of bone defects

Self-Powered Solar-Blind Photodetectors Based on Vertically Aligned GaN@Ga₂O₃ Core–Shell Nanowire Arrays

The self-powered photodetector has recently received wide attention as a fundamental component of energy-saving optoelectronic systems. In this study, the GaN@Ga2O3 core–shell nanowire arrays (NAs) were used as the photoanode for the self-powered solar-blind photoelectrochemical-type photodetectors (PEC-PDs). The vertically aligned GaN@Ga2O3 core–shell NAs on the GaN template was fabricated by the inductively coupled plasma etching combined with the thermal oxidation process. Under 255 nm illumination without an external power supply, the device exhibits a maximum responsivity of 93.48 mA/W, yielding a high external quantum efficiency of 45.54%, which shows one of the best values among the reported solar-blind Ga2O3-based PEC-PDs. Furthermore, the device shows a fast response speed (τr = 25 ms, τd = 5 ms) and good stability. Such excellent performance under zero bias may benefit from the superior light-absorbing capability of the vertical NAs, the good solid/liquid contact realized by the nanostructures, and the efficient photogenerated carrier separation driven by the double built-in electric field. This work provides a simple and feasible route to construct high-performance solar-blind Ga2O3-based PEC-PDs