Empowering Visually Impaired through the Assistance of SAHAYAK – A Walking Aid for the Blind

To help blind people overcoming difficulty in their movement in the physical environment and even in their home, a study on an engineering concept is very much necessary. So, our research comes out with an aid that will help blind people in their surroundings. It can detect any obstacle that will block the path of the blind. And The motion of the user can be sensed by the bot. Thus, Blind people can comfortably receive the help of our bot in assisting their movement from one place to another. This paper describes about an automated vehicle which can be controlled by an ultrasonic sensor to avoid obstacles when they move in their environment. Our automated robotic system is made up of an ultrasonic sensor and Arduino micro controller controls our automated bot. It is located in the front part of the bot. The ultrasonic sensor retrieves the data from the environment through the sensors attached to the bot. When any obstacle is detected then immediately that path is changed and an obstacle free path is chosen. The bot wheel is moved based on the data received by the controller from the sensor. The direction and wheel movement of the bot and will be decided from the ultrasonic sensor sensing and also using wheel encoder. It is used for detection and avoidance of interference. The controller is also programmed to be used with an android application

Smart Multi-Model Emotion Recognition System with Deep learning

Emotion recognition is added a new dimension to the sentiment analysis. This paper presents a multi-modal human emotion recognition web application by considering of three traits includes speech, text, facial expressions, to extract and analyze emotions of people who are giving interviews. Now a days there is a rapid development of Machine Learning, Artificial Intelligence and deep learning, this emotion recognition is getting more attention from researchers. These machines are said to be intelligent only if they are able to do human recognition or sentiment analysis. Emotion recognition helps in spam call detection, blackmailing calls, customer services, lie detectors, audience engagement, suspicious behavior. In this paper focus on facial expression analysis is carried out by using deep learning approaches with speech signals and input text

Electronic and magnetic excitations in the "half-stuffed" Cu--O planes of Ba2_2Cu3_3O4_4Cl2_2 measured by resonant inelastic x-ray scattering

We use resonant inelastic x-ray scattering (RIXS) at the Cu L$_3$ edge to measure the charge and spin excitations in the "half-stuffed" Cu--O planes of the cuprate antiferromagnet Ba$_2$Cu$_3$O$_4$Cl$_2$. The RIXS line shape reveals distinct contributions to the $dd$ excitations from the two structurally inequivalent Cu sites, which have different out-of-plane coordinations. The low-energy response exhibits magnetic excitations. We find a spin-wave branch whose dispersion follows the symmetry of a CuO$_2$ sublattice, similar to the case of the "fully-stuffed" planes of tetragonal CuO (T-CuO). Its bandwidth is closer to that of a typical cuprate material, such as Sr$_2$CuO$_2$Cl$_2$, than it is to that of T-CuO. We interpret this result as arising from the absence of the effective four-spin inter-sublattice interactions that act to reduce the bandwidth in T-CuO.Comment: 10 pages, 8 figure

Spin-Orbit-Induced Orbital Excitations in Sr2RuO4 and Ca2RuO4: A Resonant Inelastic X-ray Scattering Study

High-resolution resonant inelastic X-ray scattering (RIXS) at the oxygen K-edge has been used to study the orbital excitations of Ca2RuO4 and Sr2RuO4. In combination with linear dichroism X-ray absorption spectroscopy, the ruthenium 4d-orbital occupation and excitations were probed through their hybridization with the oxygen p-orbitals. These results are described within a minimal model, taking into account crystal field splitting and a spin-orbit coupling \lambda_{so}=200~meV. The effects of spin-orbit interaction on the electronic structure and implications for the Mott and superconducting ground states of (Ca,Sr)2RuO4 are discussed.Comment: accepted in PRB 201

RIP1-HAT1-SirT complex identification and targeting in treatment and prevention of cancer

Purpose: Alteration in cell death is a hallmark of cancer. A functional role regulating survival, apoptosis, and necroptosis has been attributed to RIP1/3 complexes.Experimental Design: We have investigated the role of RIP1 and the effects of MC2494 in cell death induction, using different methods as flow cytometry, transcriptome analysis, immunoprecipitation, enzymatic assays, transfections, mutagenesis, and in vivo studies with different mice models.Results: Here, we show that RIP1 is highly expressed in cancer, and we define a novel RIP1/3-SIRT1/2-HAT1/4 complex. Mass spectrometry identified five acetylations in the kinase and death domain of RIP1. The novel characterized pan-SIRT inhibitor, MC2494, increases RIP1 acetylation at two additional sites in the death domain. Mutagenesis of the acetylated lysine decreases RIP1-dependent cell death, suggesting a role for acetylation of the RIP1 complex in cell death modulation. Accordingly, MC2494 displays tumor-selective potential in vitro, in leukemic blasts ex vivo, and in vivo in both xenograft and allograft cancer models. Mechanistically, MC2494 induces bona fide tumor-restricted acetylated RIP1/caspase-8-mediated apoptosis. Excitingly, MC2494 displays tumor-preventive activity by blocking 7,12-dimethylbenz(α)anthracene-induced mammary gland hyperproliferation in vivoConclusions: These preventive features might prove useful in patients who may benefit from a recurrence-preventive approach with low toxicity during follow-up phases and in cases of established cancer predisposition. Thus, targeting the newly identified RIP1 complex may represent an attractive novel paradigm in cancer treatment and prevention

Dynamic HUB Selection Process in Wireless Body Area Network (WBAN)

Wireless body area network (WBAN), a part of WSN, plays a pivotal role in the remote health monitoring system, these days. Wireless sensor nodes placed in, on, or around the human body are used to create WBAN. This WBAN is mainly used for collecting physiological and vital signals from humans in real-time using sensor nodes. It consists of different sensor nodes and hub, which collects the data from sensor nodes and send them to the gateway. High data rates at HUB cause the damage of an organ receiving high temperature in tissue by electromagnetic signals for a long period. In this chapter, by considering parameters such as the specific absorption rate, Battery Level, Priority of sensor nodes, and signal to noise interference (SINR) a HUB is selected dynamically, which shares the work of the HUB among different sensor nodes. So that workload on HUB decreases and shares its work accordingly to other sensor nodes concerning the data collected through the software LabVIEW. This chapter also illustrates the network (testbed) created using sensors for practically making the change in HUB by using the microcontroller, power, LM 35, BP sensor, Heartrate sensors arranged in a network through Arduino programming. In both these cases, the negative effect of electro-magnetic signals in WBAN, and the tissue damage in humans reduce for remote-health monitoring while increasing the network lifetime

Anthelmintic Effects of Sericea Lespedeza Hay Fed to Goats Infected With \u3cem\u3eHaemonchus Contortus\u3c/em\u3e

Infection with gastrointestinal nematodes (GIN), particularly Haemonchus contortus, is the major hindrance to economic goat production in the southern USA. Grazing forages high in condensed tannins (CT) or adding purified CT to the diet has been shown to reduce numbers of parasite eggs in sheep and goat faeces (Min & Hart, 2003). An alternative to grazing is feeding hay from CT-containing forages to livestock to reduce the effects of GIN (Shaik et al., 2004). The purpose of the current study was to test potential anthelmintic effects of feeding sericea lespedeza [(Lespedeza cuneata (Dum.-Cours.) G. Don] hay to goats

Engineering hemoglobin to enable homogenous PEGylation without modifying protein functionality

In order to infuse hemoglobin into the vasculature as an oxygen therapeutic or blood substitute, it is necessary to increase the size of the molecule to enhance vascular retention. This aim can be achieved by PEGylation. However, using non-specific conjugation methods creates heterogenous mixtures and alters protein function. Site-specific PEGylation at the naturally reactive thiol on human hemoglobin (βCys93) alters hemoglobin oxygen binding affinity and increases its autooxidation rate. In order to avoid this issue, new reactive thiol residues were therefore engineered at sites distant to the heme group and the α/β dimer/dimer interface. The two mutants were βCys93Ala/αAla19Cys and βCys93Ala/βAla13Cys. Gel electrophoresis, size exclusion chromatography and mass spectrometry revealed efficient PEGylation at both αAla19Cys and βAla13Cys, with over 80% of the thiols PEGylated in the case of αAla19Cys. For both mutants there was no significant effect on the oxygen affinity or the cooperativity of oxygen binding. PEGylation at αAla19Cys had the additional benefit of decreasing the rates of autoxidation and heme release, properties that have been considered contributory factors to the adverse clinical side effects exhibited by previous hemoglobin based oxygen carriers. PEGylation at αAla19Cys may therefore be a useful component of future clinical products