728 research outputs found
Approximation for response adaptive designs using Stein's method
Stein's method introduced by Charles Stein (1972) is a powerful tool in distributional
approximation, especially in classes of random variables that are stochastically dependent.
In recent years, researchers have concentrated more on adaptive designs.
For the response adaptive randomization procedures, the patient's allocation depends
on the aggregated information that is acquired from the responses of the previously
treated patients. This design uses the information of patients' responses to modify
treatment allocation in order to assign more patients to a successful treatment,
thus introduce dependent structure in the data. In this thesis we investigate the
use of Stein's method in statistical inference for response adaptive design. We have
acquired asymptotic normality of the maximum likelihood estimators for treatment
effects by deriving an upper bound for these estimators using Stein's method. We
examine the performance of three types of response adaptive designs under various
success probabilities through simulation studies. Since adaptive designs generate a
dependent sequence of random variables that are not exchangeable, we present the
advantage of using bootstrap re-sampling in adaptive designs and the efficiency of
this method. We compare bootstrap confidence intervals with the asymptotic confidence interval under different success rates of three allocation methods. Also, we
discuss the normal approximation based on the Wald's statistic in the numerical
studies
{4,4′,5,5′-Tetramethyl-2,2′-[1,1′-(ethane-1,2-diyldinitrilo)diethylidyne]diphenolato}nickel(II)–methanol–chloroform (1/1/1)
In the title compound, [Ni(C22H26N2O2)]·CH3OH·CHCl3, the NiII ion is in a slightly distorted square-planar geometry involving an N2O2 atom set of the tetradentate Schiff base ligand. The asymmetric unit contains one molecule of the complex and one molecule each of chloroform and methanol. The methanol molecule is hydrogen bonded to the phenolate O atoms. In the crystal structure, short intermolecular distances between the centroids of six-membered chelate rings [3.7002 (9) Å] indicate the presence of π–π interactions, which link the molecules into stacks along the a axis. In addition, there are Ni⋯Ni distances which are shorter than the sum of the van der Waals radii of two Ni atoms. The crystal structure is further stabilized by intermolecular O—H⋯O and C—H⋯O hydrogen bonds, and weak intermolecular C—H⋯π interactions linking molecules into extended one-dimensional chains along the c axis
Spectrophotometric investigation of DL-tryptophan in the presence of Ni(II) or Co(II) ions
In the present study, synthesis of transition metal complexes of DL-tryptophan with metal precursors such as nickel (II) and cobalt (II) ions in water under refluxing conditions and optimization of the reactions to obtain the composition of complexes in water solutions has been reported. The preparation and structural elucidation of the complexes was undertaken by using physico-chemical, potentiometric titration and spectroscopic methods (UV/Vis, FT-IR and XRD). Comparisons of the spectral measurements of DL-tryptophan with those of the nickel (II) and cobalt (II) complexes are useful in determining the atoms of the ligand that are coordinated to the metal ion. In addition, K (dissociation constant) and ΔG (Gibbs free energy) values were calculated using the Babko and Stanley & Turners methods. Antibacterial and antifungal activities of the complexes were studied screened against bacteria and fungi. The activity data shows that and cobalt complexes of DL-tryptophan are more potent than the DL-tryptophan
{4,4′-Dimethoxy-2,2′-[1,1′-(ethane-1,2-diyldinitrilo)diethylidyne]diphenolato}nickel(II) hemihydrate
In the title complex, [Ni(C20H22N2O4)]·0.5H2O, the NiII ion is in a slightly distorted square-planar geometry involving an N2O2 atom set of the tetradentate Schiff base ligand. The asymmetric unit contains one molecule of the complex and half a water solvent molecule. The solvent water molecule lies on a crystallographic twofold rotation axis. An intermolecular O—H⋯O hydrogen bond forms an R
2
1(4) ring motif involving a bifurcated hydrogen bond to the phenolate O atoms of the complex. In the crystal structure, molecules are linked by π–π stacking interactions, with centroid–centroid distances in the range 3.5310 (11)–3.7905 (12) Å, forming extended chains along the b axis. In addition, there are Ni⋯Ni and Ni⋯N interactions [3.4404 (4)–4.1588 (4) and 3.383 (2)–3.756 (2) Å, respectively] which are shorter than the sum of the van der Waals radii of the relevant atoms. Further stabilization of the crystal structure is attained by weak intermolecular C—H⋯O and C—H⋯π interactions
2-[(E)-(5-Amino-2,3-diphenylquinoxalin-6-yl)iminomethyl]-4-chlorophenol
The title Schiff base compound, C27H19ClN4O, features two intramolecular O—H⋯N and N—H⋯N hydrogen bonds involving the hydroxy and amino groups to generate S(6) and S(5) ring motifs, respectively. In the crystal structure, weak intermolecular N—H⋯O and C—H⋯N interactions, together with π–π contacts [centroid–centroid distances = 3.6294 (11)–3.6881 (11) Å], link neighboring molecules
{5,5′-Dihydroxy-2,2′-[o-phenylenebis(nitrilomethylidyne)]diphenolato}nickel(II) dihydrate
In the title complex, [Ni(C20H14N2O4)]·2H2O, the NiII ion is in an essentially square-planar geometry involving an N2O2 atom set of the tetradentate Schiff base ligand. The Ni atom lies on a crystallographic twofold rotation axis. The asymmetric unit contains one half-molecule of the complex and a water molecule. An intermolecular O—H⋯O hydrogen bond forms a four-membered ring, producing an R
1
2(4) ring motif involving a bifurcated hydrogen bond to the phenolate O atoms of the complex molecule. In the crystal structure, molecules are linked by π–π stacking interactions, with centroid–centroid distances in the range 3.5750 (11)–3.7750 (11) Å. As a result of the twofold symmetry, the central benzene ring makes the same dihedral angle of 15.75 (9)° with the two outer benzene rings. The dihedral angle between the two hydroxyphenyl rings is 13.16 (5)°. In the crystal structure, molecules are linked into infinite one-dimensional chains by directed four-membered O—H⋯O—H interactions along the c axis and are further connected by C—H⋯O and π–π stacking into a three-dimensional network. An interesting feature of the crystal structure is the short Ni⋯O, O⋯O and N⋯N interactions which are shorter than the sum of the van der Waals radii of the relevant atoms. The crystal structure is stabilized by intermolecular O—H⋯O and C—H⋯O hydrogen bonds and by π–π stacking interactions
2-[(E)-(5-Amino-2,3-diphenylquinoxalin-6-yl)iminomethyl]-4-bromophenol
The title compound, C27H19BrN4O, is a mono-anil Schiff base ligand. Three intramolecular O—H⋯N and N—H⋯N hydrogen bonds involving the hydroxy and amino groups generate S(6) and S(5) ring motifs, respectively. In the crystal structure, weak intermolecular N—H⋯O and C—H⋯O hydrogen bonds together with π–π interactions [centroid–centroid distances = 3.628 (3)–3.729 (3) Å] link neighboring molecules
{6,6′-Diethoxy-2,2′-[2,2-dimethylpropane-1,3-diylbis(nitrilomethylidyne)]diphenolato}nickel(II) monohydrate
In the title complex, [Ni(C23H28N2O4)]·H2O, the NiII ion is coordinated by the N2O2 unit of the tetradentate Schiff base ligand in a slightly distorted planar geometry. The asymmetric unit of the title compound comprises one complex molecule and a water molecule of crystallization. The H atoms of the water molecule make bifurcated intermolecular hydrogen bonds with the O atoms of the phenolate and ethoxy groups with R
1
2(5) and R
1
2(6) ring motifs, which may, in part, influence the molecular configuration. The dihedral angle between the two benzene rings is 31.43 (5)°. The crystal structure is further stabilized by intermolecular C—H⋯O and C—H⋯π interactions, which link neighbouring molecules into one-dimensional extended chains along the a axis. An interesting feature of the crystal structure is the short intermolecular C⋯C [3.3044 (14) Å] contact which is shorter than the sum of the van der Waals radii
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