Does Organizational Learning Orientation Matter? Investigating the Impact of Learning Orientation on SMES Performance

The purpose of this study was to conduct an investigation into the link between organizational learning orientation and business performance in small and medium sized enterprises (SMEs).  Data were analysed using sample of 213 SMEs belonging to the manufacturing sector in Sialkot, Pakistan. The findings indicated that learning orientation is positively and significantly associated with the organizational performance of SMEs. The implications and limitations of the study are discussed and possible future research directions are provided

Types of Non-Acute Headache and Neuroimaging in the Evaluation of Patients with this Type of Headache

The aim of this study was to find the type of non-acute headache and to estimate the frequency of significant intracranial lesions in this type of headache. Non-acute headache was defined as any type of headache that had begun at least four weeks before. All the patients aged > 15 years attending the neurology and neurosurgery clinics of Post Graduate Medical Institute (PGMI), Lady Reading Hospital (LRH) Peshawar with non-acute headache were included in the study. The pregnant women and patients with facial pain alone were excluded from the study. They were followed prospectively for over a year. Detailed history and through neurlogic exami-nation was performed. The headache was classified according to the International Classification of Headache Disorder (ICHD) second edition of the International Headache Society (IHS). Every patient was investigated by neuroimaging studies. The computed tomography (CT) was done in all patients. Magnetic resonance imaging (MRI) was done in 86 patients to improve their diagnosis. Neuroimaging results were classified as “significant abnormalities”, “non-significant abnormalities” or “normal”. Significant abnormalities included neoplastic disease, hydrocephalus, vascular malformations, chiari malformation, large aracnoid cysts, intracranial hemorrhage and acute cerebral infarcts. The total number of patients was 1200; 795 women and 405 men. Their mean age was 38 years (15-75 years). Neuroimaging studies detected significant lesions in 18 patients (1.5%). The proportion of patients with headache and intracranial lesions is relatively small but neither neurological examination nor the features in the clinical history permit us to rule out such abnormalities

Frequency of Complications Following Cataract Surgery in Diabetic Patients at Tertiary Care Hospital

OBJECTIVES: To determine the frequency of complications following cataract surgery in diabetic patients admitted in the ophthalmology unit. METHODOLOGY: A prospective descriptive interventional case series study was conducted after approval of the ethical committee, from June 2017-June 2020 at the Ophthalmology department MTI-MMC. A total of 129 patients from either gender were enrolled in study. All the study patients went through detailed history and complete ocular examination. After necessary investigations, surgical procedure was carried out. Results were analyzed through the SPSS-24 version. RESULTS: Out of the total 129 eyes of the diabetic patients, fifty-nine (45.7%) were males and seventy (54.3%) were females with a ratio of 1:1.2. Uveitis leads the chart in complications found in twenty (15.50%) eyes while PODR being the least common found in only ten (7.75%) eyes. Worse visual acuity was observed in fourteen (10.85%) eyes. Striate keratopathy and posterior capsule opacification were found in sixteen (12.40%) and fifteen (11.62%) eyes respectively. Among the patients, 15.7% were having more than one complication during follow-up visits and eighty-eight (68.2%) eyes were found to have none complication. The age group 51-60 years observed frequent complications as compared to other groups. Similarly female gender (38.57%) has frequent complications as compared to males (2.7%). CONCLUSION: The study concludes Uveitis as the most common complication observed in 15.50% 0f the eyes while worse visual acuity (10.85%) and progression of diabetic retinopathy (7.75%) being the least common. Striate keratopathy was found in 12.40% while posterior capsule opacification in 11.62% of the eyes

Using Line x Tester Analysis for Earliness and Plant Height Traits in Sunflower (Helianthus annuus L.)

Line x tester analysis, involving four lines and four testers were made in sunflower for four parameters. The variance due to GCA and SCA showed that gene action was predominantly additive for days to first flowering (DFF), days to hundred percent flowering (DH%F) and plant height (PH), whereas predominance of non-additive genetic effect was discovered for days to maturity (DM). Both additive and non-additive genetic interaction was important for morpho-physiological characters in sunflower. The line TS-18 was the best general combiner for characters like DFF and PH, whereas line TS-17 was the best general combiner for DH%F and DM. The tester R-25 proved to be the best general combiner for DFF, DH%F and DM, whereas the tester 291RGI proved to be the best general combiner for PH. The SCA estimates were highest in cross TS-335 x TR-9 for DFF, TS-18 x R-25 for DH%F and DM. For PH, the best SCA cross was TS-18 x 291RGI. The best GCA parents as TS-17, TS-18, R-25 and 291RGI are recommended, which may be exploited for varietal improvement in different cross combination especially in synthetic production, whereas the three best SCA crosses are recommended  to be the best hybrids for cultivation and be included in the national uniformity yield trial for its exploration in multilocation. Additive type of gene action was observed for DFF, DH%F and PH. These characters may further be improved through simple selection method in early generation, whereas non-additive type of gene action was observed for DM, which is desirable for heterosis breeding and may be exploited in hybrid seed production

Correlation Studies among Morpho-Physiological Characters in Eight Sunflower Parents and Their Sixteen F1 Hybrids

Eight sunflower parents and their sixteen F1 hybrids were evaluated at Agricultural Research Institute Tarnab, Peshawar during autumn 2006-07 to estimate correlation among different Morpho-physiological characters. A randomized complete block design with three replicates was used. The correlation study has indicated that days to maturity was positively linked with days to first flowering, days to 100 percent flowering, internodes length and stem girth. Plant height was positively correlated with stem girth, number of leaves, days to first flowering, days to 100 percent flowering and internodes length. As revealed from results obtained that to evolve sunflower hybrid with early maturity, short stature, focus should be given to select parents having maximum stem girth, number of leaves, leaf area and minimum days to maturity and internodes length

Combined experimental and theoretical study of poly(aniline-co-pyrrole) oligomer

Quantum mechanical calculations are performed to establish the structure of an oligomer of aniline and pyrrole [Poly(Ani-co-Py)], through comparison of experimental and theoretically calculated properties, including conductivity. The copolymer was synthesized through chemical oxidative polymerization and then confirmed from the experimental IR, UV-vis, mass spectra, elemental, XRD, TGA, and SEM analysis. Quantum mechanical calculations are performed at Density Functional Theory (DFT) and Time dependent DFT (TD-DFT) methods for the electronic and spectroscopic properties of the oligomer. A very nice correlation is found between the theory and experiment which consequences the structure of Poly(Ani-co-Py). Poly(Ani-co-Py) is not explored like other conducting polymers; however, by tuning this molecular structure, the electro-active nature of this material can be enhanced adequately

Knowledge, attitudes and practices of parents regarding antibiotic use in children

Background: Emerging resistance to antimicrobial chemotherapy is becoming a challenge for medicine in recent times. Un-prescribed use of antibiotics is a major contributor to development of this problem. In Pakistan access to antibiotics remains unchecked and hence results in it are over use. The aim of this study was to assess knowledge of parents regarding use of antibiotics, its associated problems, their source of information and their expectations from Paediatricians for prescription of anti-biotics.Methods: This is a questionnaire based cross sectional study conducted in Hayatabad town, District Peshawar. Parents who were consenting, had children aged between 0-16 years, and were not related to medical profession were included in study. Total number of participants interviewed was 400. Analysis was done using prevalence ratios.Results: Most of the participants were mothers. Majority of respondents were literate with education up till level of Graduation. 64% mentioned that they enjoyed a good access to healthcare. Most common source for use of antibiotics was Physician. 35% mentioned that antibiotics must be administered in any case of fever, 47% thought antibiotics to increase recovery time and 51% knew that antibiotics have their own side effect. The most common reason to administer un-prescribed antibiotics was same antibiotic being prescribed by a physician earlier followed by family member or pharmacist recommending use of antibiotic. Lack of resources was denied as a reason for self-administration of antibiotics by majority of parents.CONCLUSION: There is a need of intervention to increase awareness regarding judicious use of antibiotics and to check un-prescribed dispensing of antibiotics

Determination of non-organ specific autoantibodies in patients with chronic hepatitis C and association with HLA DRΒ1 (*04) allele

The regulation of immune mechanisms is controlled by major histocompatibility complex/human leukocyte antigen (MHC/HLA). Polymorphisms of the HLA region have an impact on susceptibility to complex infectious and autoimmune diseases. The present study was carried out to determine the frequencies of ASMA, AMA, ANA, dsDNA, and anti-LKM-1 auto-antibodies in hepatitis C patients and to determine their association with the HLA DRβ1 (*04) locus. It was a cross-sectional, analytical study, and 86 patients with chronic HCV were recruited. The presence of auto-antibodies (ASMA, AMA, ANA, dsDNA, and anti-LKM-1) was determined by indirect immunofluorescence and ELISA, while the HLA DRβ1 (*04) allele was assessed by sequence-specific conventional PCR. ANA was detected in 41%, ASMA in 17.4%, AMA in 7%, LKM-1 in 5.8% dsDNA in 4.6% of CHC patients while HLA-DRβ1 (*04) was present in 3.5% of patients, but this was not significantly associated with these auto-antibodies

Association Of BCR-ABL Alternative Splice Variants with Disease Progression, Treatment Response and Survival in Chronic Myeloid Leukemia Patients Treated with Firstline imatinib Monotherapy

Background: Alternative RNA splicing has diverse biological effects in heath as well as disease. It also contributes to cancer onset and progression. Chronic Myeloid Leukemia (CML) results due to BCR-ABL fusion oncogene that is created due to chromosomal translocation t [9; 22] [q34; q11]). BCR-ABL is target of tyrosine kinase inhibitors (TKIs). BCR-ABL through alternative splicing can generate b2a2, b3a2 and some other rare splicing variants. BCR-ABL variants may vary in their response to TKI treatment and disease progression potential, which is a major factor contributing to dismal treatment outcome in CML. Objective: The objective of this study is to investigate correlation of BCR-ABL splice variants with TKI treatment outcome and survival in three phases of CML that has rarely been studied previously.Methods: BCR-ABL splice variants were studied using reverse transcriptase PCR (RT-PCR). in 70 CML patients from three phases of CML who were receiving imatinib (TKI) treatment.Results: Frequencies of different BCR/ABL splice variants like b3a2, b2a2 and b3a2+b2a2 were 49 (70%), 15 (21.4%) and 6 (8.6%), respectively. Splice variant b2a2 were more common (53.3%) in chronic phase CML (CP-CML) while b3a2 had higher frequency in advanced phases of CML (44.9%). CML patients with b2a2 transcript had better complete cytogenetic response and major molecular response to TKI treatment overall (100% vs. 24.5%) as well as in CP-CML (100% vs. 85.7%) and superior survival when compared to patients with b3a2 splice variant. All patients who died had male gender, less than 33 years age, b3a2 transcript, advanced phases of CML and imatinib resistance.Conclusions: Splice variant b3a2 was associated with CML progression, poorer survival and inferior treatment outcome as compared to b2a2. Further investigations on BCR-ABL splice variants and their roles in CML pathogenesis can provide deeper insights into CML biology and new targets for BCR-ABL positive leukemia treatment.          Keywords: CML; BCR-ABL splice variants; Progression; Survival; Treatment outcome