The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals

To dissect the genetic architecture of blood pressure and assess effects on target-organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 individuals of European ancestry and genotypes from an additional 140,886 individuals were used for validation. We identified 66 blood pressure loci, of which 17 were novel and 15 harbored multiple distinct association signals. The 66 index SNPs were enriched for cis-regulatory elements, particularly in vascular endothelial cells, consistent with a primary role in blood pressure control through modulation of vascular tone across multiple tissues. The 66 index SNPs combined in a risk score showed comparable effects in 64,421 individuals of non-European descent. The 66-SNP blood pressure risk score was significantly associated with target-organ damage in multiple tissues, with minor effects in the kidney. Our findings expand current knowledge of blood pressure pathways and highlight tissues beyond the classic renal system in blood pressure regulation

Simulation of multi-radio multi-channel 802.11-based mesh networks in ns-3

In the context of wireless network simulation, many simulators are capable of evaluating the performance of single-channel network protocols, but they need many modifications to be able to simulate multi-radio multi-channel networks. We address the problem of simulating channel assignment protocols for multi-radio wireless mesh networks in ns-3 simulator, providing the essential steps needed to simulate a channel assignment protocol. In addition, we explain the details of simulating the Semi-dynamic Interference aware Channel Assignment (SICA) protocol as an example. We use SICA as a reference to address the challenges of validating and verifying the simulation model. To validate the channel assignment model in SICA, we use mathematical validation based on Markov chains. Furthermore, we propose a novel automated test module to verify the simulation process.This work has been partially supported by the Spanish Government under project TEC2012-32354 (Plan Nacional I+D) and TIN2013-47272-C2-2, and by the Catalan Government (SGR-2014-1173 and SGR-2014-881