Prevalence and association of obesity with self-reported comorbidity: a cross-sectional study of 1321 adult participants in Lasbela, Balochistan

Association of fatness with chronic metabolic diseases is a well-established fact, and a high prevalence of risk factors for these disorders has increasingly been reported in the third world. In order to incorporate any preventive strategies for such risk factors into clinical practice, decision-makers require objective evidence about the associated burden of disease. A cross-sectional study of 1321 adults from one of the districts of Balochistan, among the most economically challenged areas of Pakistan, was carried out for the measures of fatness and self-reported comorbidities. Body mass index (BMI), waist circumference (WC), and waist-to-hip ratio (WHR) were measured and demographic information and self-reported comorbidities were documented.The prevalence of obesity was 4.8% (95% CI: [3.8, 6.1]) and 21.7% (95% CI: [19.5, 24.0]), as defined by the World Health Organization (WHO) international and Asia/Asia-Pacific BMI cut-offs, respectively. The proportion exhibiting comorbidity increased with increasing levels of fatness in a dose-response relationship

Programming sex, gender, and sexuality: Infrastructural failures in the "feminist" dating app Bumble

Background Bumble is a self-declared "feminist" dating app that gives women control over initiating conversations with potential matches. Analysis Through a material-semiotic analysis of Bumble's software and online media about the app, this article critically investigates how gender, sex, and sexuality are produced and given meaning by Bumble's programmed infrastructure. Conclusions and implications Since the epistemological underpinnings of Bumble's design centre gender as the solitary axis of oppression, the authors argue that the app's infrastructure generates an ontological relationship between gender, sex, and sexuality that narrows the capacity to achieve its creators' stated social justice objectives. Several infrastructural failures are detailed to demonstrate how control and safety are 1) optimized for straight cisgender women, and 2) contingent on the inscription of an aggressive form of masculinity onto straight male bodies

Association of psychosocial factors with short-term resting heart rate variability: The atherosclerosis risk in communities study

BACKGROUND: Psychosocial factors predict heart disease risk, but our understanding of underlying mechanisms is limited. We sought to evaluate the physiologic correlates of psychosocial factors by measuring their relationships with heart rate variability (HRV), a measure of autonomic health, in the ARIC (Atherosclerosis Risk in Communities) study. We hypothesize that increased psychosocial stress associates with lower HRV. METHODS AND RESULTS: We studied 9331 participants in ARIC with short-term HRV data at visits 2 and 4. The mean (SD) age was 54.4 (5.7) years, 55% were women, and 25% were Black. Psychosocial factors included: (1) vital exhaustion (VE), (2) anger proneness, a personality trait, and (3) perceived social support. Linear models adjusted for sociodemographic and cardiovascular risk factors. Low frequency HRV (ln ms2) was significantly lower in the highest versus lowest quartiles of VE (B=−0.14, 95% CI, −0.24 to −0.05). When comparing this effect to age (B=−0.04, 95% CI, −0.05 to −0.04), the difference was equivalent to 3.8 years of accelerated aging. Perceived social support associated with lower time-domain HRV. High VE (versus low VE) also associated with greater decreases in low frequency over time, and both anger and VE associated with greater increases in resting heart rate over time. Survival analyses were performed with Cox models, and no evidence was found that HRV ex-plains the excess risk found with high VE and low perceived social support. CONCLUSIONS: Vital exhaustion, and to a lesser extent anger and social support, were associated with worse autonomic function and greater adverse changes over time

Alteration in haemato-biochemical profiles of rainbow trout Oncorhynchus mykiss affected by Saprolegnia spp - A potential constraint for culture of trout in Kashmir Himalaya

Haemato-biochemical studies in rainbow trout infected with Saprolegnia were carried out under temperate climatic conditions of Kashmir valley to find out the variation in blood parameters. The trial was carried out on 405 cultured rainbow trout fish ranging in length from 47.8 to 69.8 cm and in weight from 1300 to 1920 g. The same experiment was carried out on 2,70000.00 [sic] trout fish eggs from November 2010 to April 2011 at a trout fish farm, in Kokernag, India, on account of the susceptibility of eggs to fungal infestation. The infected fish showed signs of lethargy, irritation, loss of appetite, haemorrhages at the base of fins and deep wounds at the sites of severe infection associated with cottony wool like tufts on both the dorsal and ventral sides of the body. The fungi were isolated at high percentages from skin followed by fins and mouth. The haemato-biochemical profile was studied in forty (40) normal and forty (40) infected fish. The haemoglobin content, total erythrocyte count, packed cell volume, lymphocyte percentage, total serum protein, albumin and globulin levels decreased significantly (p<0.05) in the Saprolegnia infected fish as compared to that in the control. The white blood cells, erythrocyte sedimentation rate, mean corpuscular haemoglobin, mean cell volume, heterophill percentage and total serum glucose showed significant increase in the infected fish irrespective of sex. The infection was more pronounced during the winter season (Temp.<10°C) as compared to that in summer (temp.<17°C). Fungi induced stress leads to haemostatic imbalances in fish reflected in the haemato-biochemical profile and can thus be used as an indicator for Saprolegnia induced infection

The impact of lung transplantation on esophageal motility and inter‐relationships with reflux and lung mechanics in patients with restrictive and obstructive respiratory disease

Background: For many patients with lung disease the only proven intervention to improve survival and quality of life is lung transplantation (LTx). Esophageal dysmotility and gastroesophageal reflux (GER) are common in patients with respiratory disease, and often associate with worse prognosis following LTx. Which, if any patients, should be excluded from LTx based on esophageal concerns remains unclear. Our aim was to understand the effect of LTx on esophageal motility diagnosis and examine how this and the other physiological and mechanical factors relate to GER and clearance of boluses swallowed. Methods: We prospectively recruited 62 patients with restrictive (RLD) and obstructive (OLD) lung disease (aged 33–75 years; 42 men) who underwent high resolution impedance manometry and 24-h pH-impedance before and after LTx. Key Results: RLD patients with normal motility were more likely to remain normal (p = 0.02), or if having abnormal motility to change to normal (p = 0.07) post-LTx than OLD patients. Esophageal length (EL) was greater in OLD than RLD patients' pre-LTx (p < 0.001), reducing only in OLD patients' post-LTx (p = 0.02). Reduced EL post-LTx associated with greater contractile reserve (r = 0.735; p = 0.01) and increased likelihood of motility normalization (p = 0.10). Clearance of reflux improved (p = 0.01) and associated with increased mean nocturnal baseline impedance (p < 0.001) in RLD but not OLD. Peristaltic breaks and thoraco-abdominal pressure gradient impact both esophageal clearance of reflux and boluses swallowed (p < 0.05). Conclusions and Inferences: RLD patients are more likely to show improvement in esophageal motility than OLD patients post-LTx. However, the effect on GER is more difficult to predict and requires other GI, anatomical and pulmonary factors to be taken into consideration

Adapting preference-based utility measures to capture the impact of cancer treatment-related symptoms

It is important that patient-reported outcome (PRO) measures used to assess cancer therapies adequately capture the benefits and risks experienced by patients, particularly when adverse event profiles differ across therapies. This study explores the case for augmenting preference-based utility measures to capture the impact of cancer treatment-related symptoms. Additional cancer treatment-related items could be specific (e.g., rash) or global. While specific items are easier to describe and understand, their use may miss rarer symptoms and those that are currently unknown but will arise from future medical advancements. The appropriate number of additional items, the independence of those items, and their impact on the psychometric properties of the core instrument require consideration. Alternatively, a global item could encompass all potential treatment-related symptoms, of any treatments for any disease. However, such an item may not be well understood by general public respondents in valuation exercises. Further challenges include the decision about whether to generate de novo value sets for the modified instrument or to map to existing tariffs. The fluctuating and transient nature of treatment-related symptoms may be inconsistent with the methods used in conventional valuation exercises. Fluctuating symptoms could be missed by sub-optimal measure administration timing. The addition of items also poses double-counting risks. In summary, the addition of treatment-related symptom items could increase the sensitivity of existing utility measures to capture known and unknown treatment effects in oncology, while retaining the core domains. However, more research is needed to investigate the challenges, particularly regarding valuation

Synthesis and characterization of cellulose/hydroxyapatite based dental restorative composites

The aim of this study was anin-situsynthesis of hydroxyapatite (HA) on cellulose fibers to be used as a new reinforcing agent for dental restorations. The microwave irradiation method was used for synthesis and the materials were characterized with analytical techniques. The prepared dental resin composites were mechanically tested by a universal testing machine and electrodynamic fatigue testing system. FTIR, XRD, SEM/EDS analysis confirmed the successful synthesis of HA on cellulose fibers. The Alamar blue biocompatibility assay showed more than 90% cell viability for the prepared cellulose/HA. The mechanical properties of resin composites improved with cellulose content from 30 wt.% to 50 wt.% in the polymer matrix. Substantially, increasing the cellulose/HA content from 40% to 50% improved the mechanical properties. The results suggested that HA could be successfully synthesized on cellulose fibers using microwave irradiation and contributed to improving the mechanical properties of dental resin composites