Features of a university student social portrait

Image is a sociological category that is closely related to the theory of social stratification. The field of image management is a strategic issue. In addition, it is a part of the problem that covers different areas of scientific knowledge: sociology, sociology of management, sociology of communications, management, marketing (educational marketing), etc. Universities in Russia as social organizations began to engage in image formation only in 2010, when the country began the transition to project management in the field of public and municipal administration. In particular, the requirements for the formation and promotion of the university's image began to appear within the framework of federal educational projects. For example, the Project 5-100 (2012–2020), the Program "Priority 2030" (2021 to the present century). Therefore, the issues of strategic planning in the field of image management of an educational organization are quite new for comprehension in domestic science. Aspects from the point of view of the sociology of management and the sociology of communications have been little studied. The theory and practice of strategic planning in the field of image management of an educational organization does not pay enough attention to the first important stage of planning – the analysis of recipients and translators of the image of the university. Aim. To analyze temporal variability and degree of universality of the key criteria of a university student social portrait based on primary and secondary sociological research. Methods. Classical general scientific methods – analysis, synthesis, deduction and induction. In addition, the tools of the calculation part (the apparatus for identifying statistical dependencies), as well as questionnaires, document analysis, comparative analysis and analysis of secondary information. Results. The social portrait of a university student is a stable and specific information base. The main criteria of the social portrait demonstrate the stability of characteristics of the translators and recipients of the image and motivational factors of choosing a university for five years. At the same time, the social portrait of a student in each educational institution has distinctive characteristics that make it possible to differentiate the recipients and translators of the image, as well as to form the image policy of the University for a certain Segment of the consumer of educational services. Conclusions. Strategic planning of the image policy of an educational organization should begin with the stage of sociological research with a multi-criteria allocation of a specific segment of consumers in the educational services market

From Zwiebach invariants to Getzler relation

We introduce the notion of Zwiebach invariants that generalize Gromov-Witten invariants and homotopical algebra structures. We outline the induction procedure that induces the structure of Zwiebach on the subbicomplex, that gives the structure of Gromov-Witten invariants on subbicomplex with zero diffferentials. We propose to treat Hodge dGBV with 1/12 axiom as the simplest set of Zwiebach invariants, and explicitely prove that it induces WDVV and Getzler equations in genera 0 and 1 respectively.Comment: 35 page

New insights into the genetic etiology of Alzheimer's disease and related dementias.

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Practical Questions of Diagnosis and Treatment of Helminthiasis in Children

The article presents basic information about human helminthiasis. The questions of aetiology, clinical presentation, diagnosis and treatment of the most common helminthiasis, features of their course in children are considered from modern perspectives

Some Markers of Liver Regeneration in Young Children with Congenital and Chronic Hepatitis

As a result of clinical and paraclinical studies in young children with hepatitis we detected increased concentration of hepatocyte growth factor (HGF) and tumor necrosis factor α, which indicates a high fibrous focus of inflammation in the liver, regardless of the duration of the course. Correlation between the levels of HGF and protein-bound hydroxyproline justifies the use of indicators as markers of the regenerative activity of the liver, the relationship between them increases with the duration of the pathological process

Характеристика цитокінового профілю дітей раннього віку з харчовою гіперчутливістю

Food hypersensitivity has different pathogenetic mechanisms that characterized by the composition changes of proinflammatory and anti-inflammatory cytokines.Objective: to determine the features of the cytokine profile (IL-5, TNF-α) in infants with food hypersensitivity.Material and methods. The study involved 60 children aged 1.5 months to 3 years with gastrointestinal manifestations of food hypersensitivity. The levels of total IgE and allergen-specific IgE to food allergens, eosinophilic cationic protein, IL-5 and TNF-α in serum by using enzyme immunoassay were determined in all patients.Results. In infants with food allergies there was identified sensitization to food allergens (in 70.0% of cases to the cow's milk proteins) and change of serum proinflammatory cytokines a significant increase in the cytokines serum concentration – IL-5 (5.4±0.82 ng/ml) and TNF-α (25.8±4.2 ng/ml), indicating allergic inflammation activity and correlates with high eosinophilic cationic protein along with normal findings of total IgE. Lactase deficiency is characterized by increased levels of TNF-α (4.03±0.8 ng/ml) at normal rates of IL-5 (1.56±0.5 ng/ml), total IgE and eosinophilic cationic protein.Conclusions. Composition changes of proinflammatory cytokines in the blood serum of infants with food allergy reflect the activity of allergic inflammation, and in infants with lactase deficiency indicate a possible involvement in the pathogenesis of cell-mediated inflammatory processes.Пищевая гиперчувствительность (ПГ) имеет различные патогенетические механизмы развития, которые характеризуются соответствующими изменениями состава провоспалительных и противовоспалительных цитокинов.Цель: определение особенностей цитокинового профиля (IL-5, ФНО- α) у детей раннего возраста с ПГ.Пациенты и методы. Обследовано 60 детей в возрасте от 1,5 месяцев до 3-х лет с гастроинтестинальными проявлениям ПГ, которым проводилось определение уровня общего IgE и аллергенспецифических IgE к пищевым аллергенам, эозинофильного катионного протеина, IL-5 и ФНО-α в сыворотке крови методом иммуноферментного анализа.Результаты. У детей раннего возраста с пищевой аллергией выявлена сенсибилизация к пищевым аллергенам (в 70,0% к белкам коровьего молока) и изменение состава провоспалительных цитокинов сыворотки крови — достоверное повышение концентрации цитокинов IL-5 (5,4±0,82 нг/мл) и ФНО-α (25,8±4,2 нг/мл) в сыворотке крови, что указывает на активность аллергического воспаления и коррелирует с высоким уровнем эозинофильного катионного протеина при нормальных значениях общего IgE. Лактазная недостаточность характеризуется повышением уровня ФНО-α (4,03±0,8 нг/мл) при нормальных показателях IL-5 (1,56±0,5 нг/мл), общего IgE и эозинофильного катионного протеина.Выводы. Изменения состава провоспалительных цитокинов сыворотки крови детей раннего возраста с пищевой аллергией отражают активность аллергического воспаления, а у детей с лактазной недостаточностью указывают на возможное участие в патогенезе клеточно-опосредованных воспалительных реакций.Харчова гіперчутливість (ХГ) має різні патогенетичні механізми розвитку, які характеризуються відповідними змінами складу прозапальних та протизапальних цитокінів.Мета: визначення особливостей цитокінового профілю (IL-5, ФНП-α) у дітей раннього віку з ХГ.Пацієнти і методи. Обстежено 60 дітей віком від 1,5 місяця до 3-х років з гастроінтестинальними проявами ХГ, яким проводилось визначення рівнів загального IgE та алергенспецифічних IgE до харчових алергенів, еозинофільного катіонного протеїну, IL-5 та ФНП-α у сироватці крові методом імуноферментного аналізу.Результати. У дітей раннього віку з харчовою алергією виявлена сенсибілізація до харчових алергенів (у 70,0% до білків коров'ячого молока) та зміна складу прозапальних цитокінів сироватки крові — достовірне підвищення концентрації цитокінів IL-5 (5,4±0,82 нг/мл) та ФНП-α (25,8±4,2 нг/мл) у сироватці крові, що вказує на активність алергічного запалення та корелює з високим рівнем еозинофільного катіонного протеїну при нормальних значеннях загального IgE. Лактазна недостатність характеризується підвищенням рівня ФНП-α (4,03±0,8 нг/мл) при нормальних показниках IL!5 (1,56±0,5 нг/мл), загального IgE та еозинофільного катіонного протеїну.Висновки. Зміни складу прозапальних цитокінів сироватки крові дітей раннього віку з харчовою алергією відображають активність алергічного запалення, а у дітей з лактазою недостатністю можуть бути пов'язані з участю у патогенезі клітинно-опосередкованих запальних процесів