348 research outputs found
Projection of two biphoton qutrits onto a maximally entangled state
Bell state measurements, in which two quantum bits are projected onto a
maximally entangled state, are an essential component of quantum information
science. We propose and experimentally demonstrate the projection of two
quantum systems with three states (qutrits) onto a generalized maximally
entangled state. Each qutrit is represented by the polarization of a pair of
indistinguishable photons - a biphoton. The projection is a joint measurement
on both biphotons using standard linear optics elements. This demonstration
enables the realization of quantum information protocols with qutrits, such as
teleportation and entanglement swapping.Comment: 4 pages, 3 figures, published versio
Mathematical Modeling of a Bioluminescent E. Coli Based Biosensor
In this work we present a mathematical model for the bioreporter activity of an E. coli based bioluminescent bioreporter. This bioreporter is based on a genetically modified E. coli which harbors the recA promoter, a member of the bacterial SOS response, fused to the bacterial luminescence (lux) genes. This bioreporter responds to the presence of DNA damaging agents such as heavy metals, H2O2 and Nalidixic Acid (NA) that activate the SOS response. In our mathematical model we implemented basic physiological mechanisms such as: the penetration of the NA into the biosensor; gyrase enzyme inhibition by the NA; gyrase level regulation; creation of chromosomal DNA damage; DNA repair and release of ssDNA into the cytoplasm; SOS induction and chromosomal DNA repair; activation of lux genes by the fused recA promoter carried on a plasmidal DNA; transcription and translation of the luminescence responsible enzymes; luminescence cycle; energy molecules level regulation and the regulation of the O2 consumption.
The mathematical model was defined using a set of ordinary differential equations (ODE) and solved numerically. We simulated the system for different concentrations of NA in water for specific biosensors concentration, and under limited O2 conditions. The simulated results were compared to experimental data and satisfactory matching was obtained. This manuscript presents a proof of concept showing that real biosensors can be modeled and simulated. This sets the ground to the next stage of implementing a comprehensive physiological model using experimentally extracted parameters. Following the completion of the next stage, it will be possible to construct a “Computer Aided Design” tool for the simulation of the genetically engineered biosensors. We define a term “bioCAD” for a Biological System Computer Aided Design. The specific bioCAD that is described here is aimed towards whole cell biosensors which are under investigation today for functional sensing. Usage of the bioCAD will improve the biosensors design process and boost their performance. It will also reduce Non Recurring Engineering (NRE) cost and time. Finally, using a parameterized solution will allow fair and quick evaluation of whole cell biosensors for various applications
Faster linearizability checking via -compositionality
Linearizability is a well-established consistency and correctness criterion
for concurrent data types. An important feature of linearizability is Herlihy
and Wing's locality principle, which says that a concurrent system is
linearizable if and only if all of its constituent parts (so-called objects)
are linearizable. This paper presents -compositionality, which generalizes
the idea behind the locality principle to operations on the same concurrent
data type. We implement -compositionality in a novel linearizability
checker. Our experiments with over nine implementations of concurrent sets,
including Intel's TBB library, show that our linearizability checker is one
order of magnitude faster and/or more space efficient than the state-of-the-art
algorithm.Comment: 15 pages, 2 figure
A Light Stop with Flavor in Natural SUSY
The discovery of a SM-like Higgs boson near 125 GeV and the flavor texture of
the Standard Model motivate the investigation of supersymmetric quiver-like BSM
extensions. We study the properties of such a minimal class of models which
deals naturally with the SM parameters. Considering experimental bounds as well
as constraints from flavor physics and Electro-Weak Precision Data, we find the
following. In a self-contained minimal model - including the full dynamics of
the Higgs sector - top squarks below a TeV are in tension with b->s{\gamma}
constraints. Relaxing the assumption concerning the mass generation of the
heavy Higgses, we find that a stop not far from half a TeV is allowed. The
models have some unique properties, e.g. an enhancement of the h->
b\bar{b},\tau\bar{{\tau}} decays relative to the h->\gamma{\gamma} one, a
gluino about 3 times heavier than the stop, an inverted hierarchy of about 3-20
between the squarks of the first two generations and the stop, relatively light
Higgsino neutralino or stau NLSP, as well as heavy Higgses and a W' which may
be within reach of the LHC.Comment: LaTeX, 22 pages, 4 figures; V2: references adde
A SIP-based Programming Framework for Advanced Telephony Applications
International audienceThe scope of telephony is significantly broadening, providing users with a variety of communication modes, including presence status, instant messaging and videoconferencing. Furthermore, telephony is being increasingly combined with a number of non-telephony, heterogeneous resources, consisting of software entities, such as Web services, and hardware entities, such as location-tracking devices. This heterogeneity, compounded with the intricacies of underlying technologies, make the programming of new telephony applications a daunting task. This paper proposes an approach to supporting the development of advanced telephony applications. To do so, we introduce a declarative language over Java to define the entities of a target telephony application area. This definition is passed to a generator to produce a Java programming framework, dedicated to the application area. The generated frameworks provide service discovery and high-level communication mechanisms. These mechanisms are automatically mapped into SIP, making our approach compatible with existing SIP infrastructures and entities. Our work is implemented and has been validated on various advanced telephony applications
Active dielectric antenna on chip for spatial light modulation
Integrated photonic resonators are widely used to manipulate light propagation in an evanescently-coupled
waveguide. While the evanescent coupling scheme works well for planar optical systems that are naturally
waveguide based, many optical applications are free-space based, such as imaging, display, holographics,
metrology and remote sensing. Here we demonstrate an active dielectric antenna as the interface device that
allows the large-scale integration capability of silicon photonics to serve the free-space applications. We
show a novel perturbation-base diffractive coupling scheme that allows a high-Q planer resonator to directly
interact with and manipulate free-space waves. Using a silicon-based photonic crystal cavity whose
resonance can be rapidly tuned with a p-i-n junction, a compact spatial light modulator with an extinction
ratio of 9.5 dB and a modulation speed of 150 MHz is demonstrated. Method to improve the modulation
speed is discussed.Air Force Office of Scientific Research (AFOSR grant FA9550-12-1-0261
Effect of prior treatments on selinexor, bortezomib, and dexamethasone in previously treated multiple myeloma
Therapeutic regimens for previously treated multiple myeloma (MM) may not provide prolonged disease control and are often complicated by significant adverse events, including peripheral neuropathy. In patients with previously treated MM in the Phase 3 BOSTON study, once weekly selinexor, once weekly bortezomib, and 40 mg dexamethasone (XVd) demonstrated a significantly longer median progression-free survival (PFS), higher response rates, deeper responses, a trend to improved survival, and reduced incidence and severity of bortezomib-induced peripheral neuropathy when compared with standard twice weekly bortezomib and 80 mg dexamethasone (Vd). The pre-specified analyses described here evaluated the influence of the number of prior lines of therapy, prior treatment with lenalidomide, prior proteasome inhibitor (PI) therapy, prior immunomodulatory drug therapy, and prior autologous stem cell transplant (ASCT) on the efficacy and safety of XVd compared with Vd. In this 1:1 randomized study, enrolled patients were assigned to receive once weekly oral selinexor (100 mg) with once weekly subcutaneous bortezomib (1.3 mg/m2) and 40 mg per week dexamethasone (XVd) versus standard twice weekly bortezomib and 80 mg per week dexamethasone (Vd). XVd significantly improved PFS, overall response rate, time-to-next-treatment, and showed reduced all grade and grade ≥ 2 peripheral neuropathy compared with Vd regardless of prior treatments, but the benefits of XVd over Vd were more pronounced in patients treated earlier in their disease course who had either received only one prior therapy, had never been treated with a PI, or had prior ASCT. Treatment with XVd improved outcomes as compared to Vd regardless of prior therapies as well as manageable and generally reversible adverse events. XVd was associated with clinical benefit and reduced peripheral neuropathy compared to standard Vd in previously treated MM. These results suggest that the once weekly XVd regimen may be optimally administered to patients earlier in their course of disease, as their first bortezomib-containing regimen, and in those relapsing after ASCT. Trial registration: ClinicalTrials.gov (NCT03110562). Registered 12 April 2017. https://clinicaltrials.gov/ct2/show/NCT03110562
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