Histiocytose langerhansienne multiviscerale avec atteinte auriculaire bilaterale a propos d’une observation

L’histiocytose langerhansienne multi-viscérale est une prolifération clonale des cellules de Langerhans, touchant plusieurs organes. Cette entité se voit surtout chez l’enfant. Dans ce travail, nous rappelons les aspects cliniques avec la fréquence d’atteinte oto-rhino-laryngologique, ainsi que les moyens de diagnostic et le traitement de cette affection rare. Nous présentons le cas d’un enfant âgé de 2 ans qui a été hospitalisé pour une pneumopathie interstitielle, associée à une otorrhée bilatérale. L’examen a montré un comblement des 2 conduits auditifs externes et des lésions cutanées squameuses. La biopsie a conclu à une histiocytose langerhansienne. Malgré la chimiothérapie, l’enfant est décédé après 11 mois.Mots-clés : Histiocytose langerhansienne, atteinte auriculaire

Facteurs Predictifs De Malignite D\'un Nodule Thyroidien

Buts : étudier les facteurs prédictifs de malignité des nodules thyroïdiens et comparer nos résultats à ceux de la littérature. Patients et méthodes : Il s\'agit d\'une étude rétrospective a propos de 282 cas de nodules thyroïdiens opérés à l\' hôpital de Mahdia entre 1988 et 2003. Résultats : L\'âge moyen était de 44 ans. Le risque de malignité des nodules thyroïdiens était de 15,6% . Ce risque était plus important chez les hommes (50%) que chez les femmes (13,3%). Certains facteurs étaient hautement prédictifs de malignité comme l\'âge supérieur à 60 ans, les signes de compression, les adénopathies cervicales et le caractère fixe et dure du nodule thyroidien Conclusion : Certains signes cliniques et para cliniques ont une grande valeur en matière de bénignité ou de malignité des nodules thyroïdiens.Aim : Study the predictive factors of malignancy of thyroid gland nodules and compare our results to those of the literature. Patients and methods : A retrospective study about 282 cases of thyroid gland nodules treated in Madhya hospital between 1988 and 2003. Results : The middle age was 44 years. The risk of malignancy was 15,6 %. This risk was higher in men (50 %) then in women (13,3 %). Some factors were highly predictive of malignancy like age superior then 60 years, neck lymph nodes … Conclusion: Some clinic and para clinic signs have an important value in benignancy or malignancy of thyroid gland nodules. Journal Tunisien d\'ORL et de chirurgie cervico-faciale Vol. 18 2007: pp. 20-2

Experience du service de medecine nucleaire sahloul sousse dans la prise en charge des carcinomes differencies de la thyroïde a thyroglobuline elevee.

But : L’objectif de notre travail est de présenter notre expérience dans la prise en charge des cancer différencié de la thyroïde (CDT) à Thyroglobuline (Tg) élevée, tout en identifiant les paramètres modifiant l’efficacité de l’Irathérapie et la valeur seuil de la Tg permettant avec un balayage post thérapeutique négatif de conclure à une rémission.Matériels et méthodes : Il s’agit d’une étude rétrospective portant sur 150 patients opérés pour CDT, suivis entre 1990 et 2006 et présentant une Tg>2ng/ml.Résultats : Il s’agit de 122 femmes et 28 hommes. L’âge moyen était de 52 ans. La Tg ne dépendait pas du type histologique mais il existait une relation statistiquement significative entre la Tg et la taille tumorale, l’atteinte ganglionnaire, l’extension locorégionale, la présence de métastases et le stade TNM. La réponse thérapeutique des CDT avec une Tg élevée dépendait de l’âge des patients, des caractéristiques anatomopathologiques de la tumeur et des valeurs de la Tg.Conclusion : L’efficacité ablative est optimisée par des cures d’iode 131 qui doivent être prolongées tant que la Tg reste élevée. La surveillance à vie, au cours de la quelle on exige des seuils de Tg infèrieurs à 2ng/ml, est nécessaire. Mots clés : Cancers différenciés de la thyroide, Thyroglobuline, Irathérapie, Pronostic, Surveillance.Purpose: The aim of our work is to present our experience in the management of differentiated thyroid cancer (DTC) with high thyroglobulin (Tg) , to identify parameters changing iodine effectiveness and Tg threshold with negative post treatment scan conclude to remission.Materials and Methods: This is a retrospective study of 150 patients undergoing CDT, followed between 1990 and 2006 and having a Tg > 2ng/ml .Results: Our study concerns 122 women and 28 men. The average age was 52 years . Tg value does not depend on the histological type but there was a statistically significant relationship between Tg and tumor size, lymph node involvement, locoregional , metastasis and TNM stage . The therapeutic response of CDT with a high Tg was dependent on the age of patients, the pathological characteristics of the tumor and the Tg values ofConclusion: The ablative efficiency is optimized by 131 cures iodine should be extended until the Tg remains high. Monitoring life is necessary and the thresholds Tg below 2ng/ml is required.Keywords: Differentiated thyroid Cancers, Thyroglobulin, Iodine 131, Prediction, Monitoring

Prospects for Heavy Neutral Lepton Searches at Short and Medium Baseline Reactor Experiments

Heavy neutrinos with masses in the MeV range can in principle simultaneously explain the light neutrino masses and the origin of baryonic matter in the universe. The strongest constraints on their properties come from their potential impact on the formation of light elements in the early universe. Since these constraints rely on assumptions about the cosmic history, independent checks in the laboratory are highly desirable. In this paper, we discuss the opportunity to search for heavy neutrinos within the MeV mass range in short and medium baseline reactor neutrino experiments, using the SoLid, JUNO and TAO experiments as examples. This kind of experiments can give the currently strongest upper bound on the mixing between the light electron neutrinos and the heavy neutrino in the 2-9 MeV mass range.Comment: submitted to JHE

Study of the B +→ J / ψ Λ ¯ p decay in proton-proton collisions at √s = 8 TeV

A study of the B +→ J / ψ Λ ¯ p decay using proton-proton collision data collected at s = 8 TeV by the CMS experiment at the LHC, corresponding to an integrated luminosity of 19.6 fb−1, is presented. The ratio of branching fractions B(B+→J/ψΛ¯p)/B(B+→J/ψK∗(892)+) is measured to be (1.054 ± 0.057(stat) ± 0.035(syst) ± 0.011(B))%, where the last uncertainty reflects the uncertainties in the world-average branching fractions of Λ ¯ and K*(892) + decays to reconstructed final states. The invariant mass distributions of the J / ψ Λ ¯ , J/ψp, and Λ ¯ p systems produced in the B +→ J / ψ Λ¯ p decay are investigated and found to be inconsistent with the pure phase space hypothesis. The analysis is extended by using a model-independent angular amplitude analysis, which shows that the observed invariant mass distributions are consistent with the contributions from excited kaons decaying to the Λ ¯ p system. [Figure not available: see fulltext.

Measurement of the top quark Yukawa coupling from t t kinematic distributions in the lepton+jets final state in proton-proton collisions at s =13 TeV MEASUREMENT of the TOP QUARK YUKAWA COUPLING from ... SIRUNYAN et al.

Results are presented for an extraction of the top quark Yukawa coupling from top quark-antiquark (tt) kinematic distributions in the lepton plus jets final state in proton-proton collisions, based on data collected by the CMS experiment at the LHC at s=13 TeV, corresponding to an integrated luminosity of 35.8 fb-1. Corrections from weak boson exchange, including Higgs bosons, between the top quarks can produce large distortions of differential distributions near the energy threshold of tt production. Therefore, precise measurements of these distributions are sensitive to the Yukawa coupling. Top quark events are reconstructed with at least three jets in the final state, and a novel technique is introduced to reconstruct the tt system for events with one missing jet. This technique enhances the experimental sensitivity in the low invariant mass region, Mtt. The data yields in Mtt, the rapidity difference |yt-yt|, and the number of reconstructed jets are compared with distributions representing different Yukawa couplings. These comparisons are used to measure the ratio of the top quark Yukawa coupling to its standard model predicted value to be 1.07-0.43+0.34 with an upper limit of 1.67 at the 95% confidence level

Search for new neutral Higgs bosons through the H → ZA→ ℓ+ℓ−b b ¯ process in pp collisions at √s = 13 TeV

This paper reports on a search for an extension to the scalar sector of the standard model, where a new CP-even (odd) boson decays to a Z boson and a lighter CP-odd (even) boson, and the latter further decays to a b quark pair. The Z boson is reconstructed via its decays to electron or muon pairs. The analysed data were recorded in proton-proton collisions at a center-of-mass energy s = 13 TeV, collected by the CMS experiment at the LHC during 2016, corresponding to an integrated luminosity of 35.9 fb−1. Data and predictions from the standard model are in agreement within the uncertainties. Upper limits at 95% confidence level are set on the production cross section times branching fraction, with masses of the new bosons up to 1000 GeV. The results are interpreted in the context of the two-Higgs-doublet model. [Figure not available: see fulltext.]

Search for a heavy Higgs boson decaying to a pair of W bosons in proton-proton collisions at √s = 13 TeV

A search for a heavy Higgs boson in the mass range from 0.2 to 3.0 TeV, decaying to a pair of W bosons, is presented. The analysis is based on proton-proton collisions at s = 13 TeV recorded by the CMS experiment at the LHC in 2016, corresponding to an integrated luminosity of 35.9 fb−1. The W boson pair decays are reconstructed in the 2ℓ2ν and ℓν2q final states (with ℓ = e or μ). Both gluon fusion and vector boson fusion production of the signal are considered. Interference effects between the signal and background are also taken into account. The observed data are consistent with the standard model (SM) expectation. Combined upper limits at 95% confidence level on the product of the cross section and branching fraction exclude a heavy Higgs boson with SM-like couplings and decays up to 1870 GeV. Exclusion limits are also set in the context of a number of two-Higgs-doublet model formulations, further reducing the allowed parameter space for SM extensions. [Figure not available: see fulltext.