The Correlation of Magee Equations (TM) and Oncotype DX (R) Recurrence Score From Core Needle Biopsy Tissues in Predicting Response to Neoadjuvant Chemotherapy in ER+ and HER2- Breast Cancer

WOS: 000524026100008Objective: Oncotype DX (R) recurrence score (RS) can be predicted from Magee Equations (TM) (MS) postoperatively. The aim of this study is to investigate correlation of MS with RS from pretreatment core needle biopsy (CNB) [issues, and their clinical usefulness in prediction of response to neoadjuvant chemotherapy (NCT) in estrogen receptor-positive and human epidermal growth factor receptor 2-negative (ER+/HER2-) breast cancer (BC). Materials and Methods: Prerrearmenr CNB tissue samples from 60 patients with ER+ /HER2- invasive BC were analyzed for MS and RS correlation. MS and RS were categorized as follows low (= 31). Percentage Tumor size Reduction (%TR) was used to assess tumor response to NCT, and substantial %TR was defined as at least 50% reduction (.50%TR). Correlation between MS and RS, and predictisv factors for the >= 50%TR achievement were assessed. Results: MS and RS represen red a strong correlation (Spearman's correlation; r-0.58, p= 50% TR achievemenr, none of the factors were Magically significant (p >= 0.07). Conclusion: Our study demonstrated that there was a strong correlation between MS and RS from pretreatment biopsy tissue samples in ER+ and HER2- invasive. BC

Factors related to recurrence of idiopathic granulomatous mastitis: what do we learn from a multicentre study?

Background: Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory disease of the breast with unknown aetiology. Its treatment is controversial and the recurrence rate is high. The objectives of this study were to examine the demographic, sociocultural and clinical characteristics observed among a large cohort of IGM patients from Turkey and to identify factors related to the recurrence of IGM. Methods: The study was designed as a multicentre retrospective study including 22 breast centres in Turkey. A total of 720 IGM patients are included in the study. Patient data were obtained from the patient's files and electronic records based on the study protocol. Patients’ demographic, clinical, radiological, treatment and recurrence of IGM related characteristics were recorded. Results: Our results revealed a statistically significant association between IGM recurrence and history of pregnancy, breastfeeding, breast infection and smoking (P 0.05). Conclusion: Our findings show that history of pregnancy, breastfeeding, breast infection and smoking were the risk factors for IGM recurrence. As current treatment methods did not affect IGM recurrence, recurrence-related factors, such as breast infection and smoking, should be considered to eliminate while focusing on less invasive local treatment research

Lesion of Aggregated Monocytes and Mesothelial Cells: Mesothelial/Monocytic Incidental Cardiac Lesion

A 58-year-old woman with a history of childhood acute rheumatic fever and resultant mitral valve stenosis was admitted to our cardiovascular surgery clinic complaining of tachycardia, dyspnea, and chest pain. After clinical and radiological findings were evaluated, mitral valve replacement, tricuspid De Vega annuloplasty and plication, and resection of giant left atrium were performed. Atrial thrombus was removed from the top of the left atrial wall. Operation material considered as thrombus was sent to a pathology laboratory for histopathological examination. It was diagnosed with mesothelial/monocytic incidental cardiac lesion (cardiac MICE). Microscopic sections revealed that morphological features of the lesion were different from thrombus. The lesion was composed of a cluster of histiocytoid cells with abundant cytoplasm and oval shaped nuclei and epithelial-like cells resembling mesothelial cells within a fibrin network. Epithelial-like cells formed a papillary configuration in the focal areas. Mitotic figures were absent. Here we present a case which was incidentally found in a patient who underwent mitral valve replacement surgery, as a thrombotic lesion on the left atrium wall

Simulation of Voltage Sag Events in Distribution Networks and Utility-Side Mitigation Methods

As industrialization and automation processes continue to expand, power quality parameters and voltage sags in particular become more important. Sensitive equipment trips due to voltage sags cause enormous financial loss in the industrial sector. Consequently, in consultation with AF Turkey, Trakya Electricity Distribution Company (TREDAS) began an R&D project on voltage sags funded by the Turkish Energy Market Regulatory Authority (EMRA). The project aims to characterize voltage sags and perform research into sag mitigation methods. In this paper, the results of the simulation studies of a feeder located in the Thrace region are presented. The effects of short circuit faults on the development of voltage sag events and utility-side mitigation methods are analyzed through computer simulations using EMTP-RV software. Furthermore, definitions of voltage sag indices according to IEEE Std. 1564-2014 are given and the methods used to minimize the effects of voltage sags are explained

Primary Tumor Surgery in Patients with De Novo Bone-only Stage IVA/B Breast Cancer: MetS: Protocol MF22-03, Combination Data Analysis of Prospective Studies

24th Annual Meeting of The American Society of Breast Surgeons (ASBrS) -- APR 26-30, 2023 -- MS --[No abstract available