Oxidative Stress in Patients With Nongenital Warts

Comparison of oxidative stress status between subjects with or without warts is absent in the literature. In this study, we evaluated 31 consecutive patients with warts (15 female, 16 male) and 36 control cases with no evidence of disease to determine the effects of oxidative stress in patients with warts. The patients were classified according to the wart type, duration, number, and location of lesions. We measured the indicators of oxidative stress such as catalase (CAT), glucose-6-phosphate dehydrogenase (G6PD), superoxide dismutase (SOD), and malondialdehyde (MDA) in the venous blood by spectrophotometry. There was a statistically significant increase in levels of CAT, G6PD, SOD activities and MDA in the patients with warts compared to the control group (P < .05). However, we could not define a statistically significant correlation between these increased enzyme activities and MDA levels and the type, the duration, the number, and the location of lesions. We determined possible suppression of T cells during oxidative stress that might have a negative effect on the prognosis of the disease. Therefore, we propose an argument for the appropriateness to give priority to immunomodulatory treatment alternatives instead of destructive methods in patients with demonstrated oxidative stress

Oxidative Stress in Patients With Acne Vulgaris

Acne vulgaris is one of the common dermatological diseases and its pathogenesis is multifactorial. In this study, we aim to determine the effects of oxidative stress in acne vulgaris. Forty-three consecutive acne patients and 46 controls were enrolled. The parameters of oxidative stress such as catalase (CAT), glucose-6-phosphate dehydrogenase (G6PD), superoxide dismutase (SOD), and malondialdehyde (MDA) in the venous blood of cases were measured spectrophotometrically. The values compared with control group, the relation between the severity and distribution of acne, and the correlation of each enzyme level were researched. CAT and G6PD levels in patients were found to be statistically decreased, and SOD and MDA levels were found to be statistically increased (P < .001). However, any statistical difference and correlation could not be found between the severity and distribution of lesions and the mean levels of enzymes. In addition, we found that each enzyme is correlated with one another. Our findings show that oxidative stress exists in the acne patients. It will be useful to apply at least one antioxidant featured drug along with the combined acne treatment

Serum Levels of TNF-α, IFN-γ, IL-6, IL-8, IL-12, IL-17, and IL-18 in Patients With Active Psoriasis and Correlation With Disease Severity

Recent progress in the understanding of psoriasis has shown that the regulation of local and systemic cytokines plays an important role in its pathogenesis. The most often used psoriasis score is the psoriasis area and severity index (PASI). A simple laboratory test from a blood sample would be an attractive, patient-independent, and observer-independent marker of disease severity. To this end, we evaluated the association of serum levels of some proinflammatory cytokines in vivo and their correlation with severity of psoriasis. The serum levels of cytokines levels were determined with the use of the ELISA method. All mean values except IL-17 levels of patients were significantly higher than those of controls. There was a significant correlation between serum levels of IFN-γ, IL-12, IL-17, and IL-18, and severity of the disease. Psoriasis can be described as a T-cell-mediated disease, with a complex role for a variety of cytokines, which has led to the development of new immunomodulatory therapies. In this study, serum TNF-α, IFN-γ, IL-6, IL-8, IL-12, and IL-18 levels were significantly higher in active psoriatic patients than in controls. Furthermore, high levels of IFN-γ, IL-12, and IL-18 correlated with the clinical severity and activity of psoriasis, and those measurements of serum levels of these cytokines may be objective parameters for the disease severity

Skin diseases in Turkish soldiers

This study aimed to determine the prevalence of skin diseases among soldiers who were assigned duties in Kahramanmaras, a province of east Mediterranean region of Turkey. One hundred eighty-eight soldiers were assessed for skin diseases by a complete dermatological examination and the findings were recorded to a form. Apart from the low number of older ones, the soldiers were of 20–22 years. The diagnosis of superficial fungal infections was made by the use of potassium hydroxide preparations in addition to clinical appearance. On completion of the study period, the data were evaluated, and patients were grouped. Pitted keratolysis was the primary dermatologic disease in 34.5% of the soldiers, 29.2% were diagnosed with oral candidiasis, and 25.5% suffered from tinea pedis. Among the soldiers suffering from a cutaneous disease, dyshidrotic eczema (18.6%), intertrigo (excluding candidal intertrigo) (17%), acne (17%), seborrheic dermatitis (14.9%), plantar hyperkeratosis (14.3%), contact dermatitis (13.8%), and folliculitis (12.2%) were the other most frequent dermatoses. Other less frequent dermatoses were asteatotic eczema, callus, onychomycosis, traumatic onychodystrophy, and so on. We conclude that the prevalence of skin diseases in soldiers is very high and is one of the major public health problems that have a significant burden on our nation

Bilateral Nevoid Hyperkeratosis of the Nipple and/or Areola: A Case Report

Nevoid hyperkeratosis of the nipple and areola (NHNA) is a rare condition, in which the skin of the nipple and/or areola becomes diffusely thickened, hyperpigmented, and covered with filiform or papular warty excrescences. Although it affects both men and woman, approximately 80% of cases ocur in women. Pathogenic mechanisms have been proposed but mainly unsubstantiated. Moreover, specific treatment guidelines do not exist partly because of the unknown pathogenesis of this disorder. We report a female patient with this rare condition. [Med-Science 2015; 4(2.000): 2252-6

Cutaneous lymphoid hyperplasia: a case report

Cutaneous lymphoid hyperplasia (CLH), occurring as a result of various antigenic stimuli, is considered as a process of reactive lymphoid and may have potential for progression to overt lymphoma. CLH lesions may resemble lymphoma both clinically and histologically. We present a case of a 24-year-old man who spontaneously developed lesions of unknown cause consistent with cutaneous lymphoid hyperplasia. Thus, in this study we discuss the etiology, clinical features, diagnosis, and management of CLH and also review the literature