9 research outputs found
Ag nanoparticle promoted synthesis of 1,8-dioxo-decahydroacridines at room temperature
The three component condensation reaction of aldehydes with dimedone and ammonium acetate or anilines happened in the presence of Ag nanoparticles as a heterogeneous catalyst at room temperature in ethanol.Ag nanoparticles can suitably be handled and removed from the reaction mixture, generating the experimental process simple and green.The significant features of this method are suitable conversions, cleaner reaction profiles and short reaction time. The catalyst is recycled and reused for five successive times without loss of structure and significant activity
Ag nanoparticle promoted synthesis of 1,8-dioxo-decahydroacridines at room temperature
1303-1308The three component condensation reaction of aldehydes with dimedone and ammonium acetate or anilines happened in
the presence of Ag nanoparticles as a heterogeneous catalyst at room temperature in ethanol.Ag nanoparticles can suitably
be handled and removed from the reaction mixture, generating the experimental process simple and green.The significant
features of this method are suitable conversions, cleaner reaction profiles and short reaction time. The catalyst is recycled
and reused for five successive times without loss of structure and significant activity
Protic guanidinium ionic liquid as a green and highly efficient catalyst for the synthesis of functionalized spirochromenes under solvent-free conditions
Poly (β-Cyclodextrin-co-citric Acid) Functionalized Natural Nanozeolite: An Eco-Friendly Platform for IB Delivery
Zeolites, due to their porous nature and inherent pH-sensitive properties, are widely studied as drug delivery systems. However, natural zeolite pores are usually larger than drug molecules, which can cause rapid drug release. Consequently, to solve this problem, the zeolite structure must be modified to achieve controlled drug release. On the other hand, the preparation of nanoscale zeolites enables them to enter the living cell. To achieve these objectives, a natural nanozeolite was modified by poly (β-cyclodextrin-co-citric acid) (PCD-zeolite), and used for the loading and release of IB (IB). The PCD-zeolite was synthesized by heating a mixture of citric acid (CA), cyclodextrin (CD), and Na2HPO4; it was characterized by FT-IR, TGA, and TEM analyses. Due to the presence of hydroxyl and carboxyl groups in the PCD-zeolite structure, pH plays a vital role in the adsorbed IB; thus, the maximum adsorbed IB was observed at pH = 7. The in vitro release of IB from PCD-zeolite-IB in a phosphate buffer was examined; the PCD-zeolite containing IB (30 wt%) showed the highest release at pH = 3.6 within the first 3–48 h. As a result, the PCD-zeolite, by trapping IB, can improve its solubility and bioavailability. Moreover, the decrease in the dissolution rate of the polymer matrix in an acidic medium may also lower the toxicity of IB