Electrochemical reduction of carbamazepine in ethanol and water solutions using a glassy carbon electrode

The electrochemical reduction of carbamazepine in ethanol and water using a glassy carbon electrode has been studied. In all experimental conditions of scan rate and concentration of carbamazepine an irreversible cathodic wave was observed by cyclic voltammetry (CV). Electrochemical parameters and a plausible EqC mechanism have been reported from the electrochemical measurements and digital simulation. The values of thermodynamic E1/2 were correlated with solvent polarity parameters that it can be interesting for biological, pharmaceutical and forensic purposes. Limits of Detection (LOD) for DPV are 1.1 and 9.0 g/mL (4.65x10-6 and 3.81x10-5 M) in ethanol and water, respectively. The precision and recoveries obtained for tablets and plasma samples showed that the method could be successfully used for analysis

Didáctica de la traducción al español de paremias francesas.

Sin resume

Flavour constraints on scenarios with two or three heavy squark generations

We re-assess constraints from flavour-changing neutral currents in the kaon system on supersymmetric scenarios with a light gluino, two heavy generations of squarks and a lighter third generation. We compute for the first time limits in scenarios with three heavy squark families, taking into account QCD corrections at the next-to-leading order. We compare our limits with those in the case of two heavy families. We use the mass insertion approximation and consider contributions from gluino exchange to constrain the mixing between the first and second squark generation. While it is not possible to perform a general analysis, we assess the relevance of each kind of flavour- and CP-violating parameters. We also provide ready to use magic numbers for the computation of the Wilson coefficients at 2 GeV for these scenarios.Comment: 23 pages, 14 figures; v3: matches published version (contains improvements in the presentation and clarifications

Leptogenesis and μ−τ\mu-\tau symmetry

If an exact $\mu\leftrightarrow \tau$ symmetry is the explanation of the maximal atmospheric neutrino mixing angle, it has interesting implications for origin of matter via leptogenesis in models where small neutrino masses arise via the seesaw mechanism. For seesaw models with two right handed neutrinos $(N_\mu, N_\tau)$, lepton asymmetry vanishes in the exact $\mu\leftrightarrow \tau$ symmetric limit, even though there are nonvanishing Majorana phases in the neutrino mixing matrix. On the other hand, for three right handed neutrino models, lepton asymmetry nonzero and is given directly by the solar mass difference square. We also find an upper bound on the lightest neutrino mass.Comment: 5 pages; latex; no figures; some typos correcte

Leukocyte adhesion deficiency-I: A comprehensive review of all published cases

Leukocyte adhesion deficiency-I (LAD-I) is a rare, serious disorder with severity determined by defective CD18 expression. LAD-I is characterized by umbilical complications, granulocytosis, and diverse infections. Severe LAD-I is frequently fatal before the age of 2 years without allogeneic transplant. We identified 323 cases published between 1975 and 2017

Genetic epidemiology of the Charcot-Marie-Tooth in the Spanish Gypsy population: the Hereditary Motor and Sensory Neuropathy type Russe in depth

[EN] Four private mutations responsible for three forms demyelinating of Charcot-Marie-Tooth (CMT) or hereditary motor and sensory neuropathy (HMSN) have been associated with the Gypsy population: the NDRG1 p.R148X in CMT type 4D (CMT4D/HMSN-Lom); p.C737_P738delinsX and p.R1109X mutations in the SH3TC2 gene (CMT4C); and a G>C change in a novel alternative untranslated exon in the HK1 gene causative of CMT4G (CMT4G/HMSN-Russe). Here we address the findings of a genetic study of 29 Gypsy Spanish families with autosomal recessive demyelinating CMT. The most frequent form is CMT4C (57.14%), followed by HMSN-Russe (25%) and HMSN-Lom (17.86%). The relevant frequency of HMSN-Russe has allowed us to investigate in depth the genetics and the associated clinical symptoms of this CMT form. HMSN-Russe probands share the same haplotype confirming that the HK1 g.9712G>C is a founder mutation, which arrived in Spain around the end of the 18th century. The clinical picture of HMSN-Russe is a progressive CMT disorder leading to severe weakness of the lower limbs and prominent distal sensory loss. Motor nerve conduction velocity was in the demyelinating or intermediate range.We thank all patients and their relatives for their kind collaboration. We also thank Drs G. Glover, R. Vilches, F. Galan, and C. Diaz for referring patients for genetic analysis. We also acknowledge F Barraclough for English corrections. This work was supported by the Instituto de Salud Carlos III (ISCIII) (grants number PI08/90857, PI08/0889, CP08/00053 and PS09/00095) co-funded with FEDER funds and by the ISCIII-IRDiRC Programme (TREAT-CMT grant). C. E. has a 'Miguel Servet' contract funded by the ISCIII. Both Centro de Investigacion Biomedica en Red de Enfermedades Raras (CIBERER) and Centro de Investigacion Biomedica en Red de Enfermedades Neurodegenerativas (CIBERNED) are initiative from the ISCIII.Sevilla, T.; Martínez-Rubio, D.; Márquez, C.; Paradas, C.; Colomer, J.; Jaijo, T.; Millán, J.... (2013). Genetic epidemiology of the Charcot-Marie-Tooth in the Spanish Gypsy population: the Hereditary Motor and Sensory Neuropathy type Russe in depth. Clinical Genetics. 83(6):565-570. https://doi.org/10.1111/cge.1201556557083