923 research outputs found
Bivariate Beta-LSTM
Long Short-Term Memory (LSTM) infers the long term dependency through a cell
state maintained by the input and the forget gate structures, which models a
gate output as a value in [0,1] through a sigmoid function. However, due to the
graduality of the sigmoid function, the sigmoid gate is not flexible in
representing multi-modality or skewness. Besides, the previous models lack
modeling on the correlation between the gates, which would be a new method to
adopt inductive bias for a relationship between previous and current input.
This paper proposes a new gate structure with the bivariate Beta distribution.
The proposed gate structure enables probabilistic modeling on the gates within
the LSTM cell so that the modelers can customize the cell state flow with
priors and distributions. Moreover, we theoretically show the higher upper
bound of the gradient compared to the sigmoid function, and we empirically
observed that the bivariate Beta distribution gate structure provides higher
gradient values in training. We demonstrate the effectiveness of bivariate Beta
gate structure on the sentence classification, image classification, polyphonic
music modeling, and image caption generation.Comment: AAAI 202
Crystal base of the negative half of the quantum superalgebra
We construct a crystal base of , the negative half
of the quantum superalgebra . We give a combinatorial
description of the associated crystal , which is
equal to the limit of the crystals of the (-deformed) Kac modules
. We also construct a crystal base of a parabolic Verma module
associated with the subalgebra , and
show that it is compatible with the crystal base of
and the Kac module under the canonical embedding and projection of
to and , respectively.Comment: 43 page
The Light and Period Variations of the Eclipsing Binary BX Draconis
New CCD photometric observations of BX Dra were obtained for 26 nights from
2009 April to 2010 June. The long-term photometric behaviors of the system are
presented from detailed studies of the period and light variations, based on
the historical data and our new observations. All available light curves
display total eclipses at secondary minima and inverse O'Connell effects with
Max I fainter than Max II, which are satisfactorily modeled by adding the
slightly time-varying hot spot on the primary star. A total of 87 times of
minimum light spanning over about 74 yrs, including our 22 timing measurements,
were used for ephemeris computations. Detailed analysis of the O-C diagram
showed that the orbital period has changed in combinations with an upward
parabola and a sinusoidal variation. The continuous period increase with a rate
of +5.65 \times 10^-7 d yr^-1 is consistent with that calculated from the
Wilson-Devinney synthesis code. It can be interpreted as a mass transfer from
the secondary to the primary star at a rate of 2.74 \times 10^-7 M\odot yr^-1,
which is one of the largest rates for contact systems. The most likely
explanation of the sinusoidal variation with a period of 30.2 yrs and a
semi-amplitude of 0.0062 d is a light-traveltime effect due to the existence of
a circumbinary object. We suggest that BX Dra is probably a triple system,
consisting of a primary star with a spectral type of F0, its secondary
component of spectral type F1-2, and an unseen circumbinary object with a
minimum mass of M3 = 0.23 M\odot.Comment: 24 pages, including 5 figures and 9 tables, accepted for publication
in PAS
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AAVR-Displaying Interfaces: Serotype-Independent Adeno-Associated Virus Capture and Local Delivery Systems.
Interfacing gene delivery vehicles with biomaterials has the potential to play a key role in diversifying gene transfer capabilities, including localized, patterned, and controlled delivery. However, strategies for modifying biomaterials to interact with delivery vectors must be redesigned whenever new delivery vehicles and applications are explored. We have developed a vector-independent biomaterial platform capable of interacting with various adeno-associated viral (AAV) serotypes. A water-soluble, cysteine-tagged, recombinant protein version of the recently discovered multi-AAV serotype receptor (AAVR), referred to as cys-AAVR, was conjugated to maleimide-displaying polycaprolactone (PCL) materials using click chemistry. The resulting cys-AAVR-PCL system bound to a broad range of therapeutically relevant AAV serotypes, thereby providing a platform capable of modulating the delivery of all AAV serotypes. Intramuscular injection of cys-AAVR-PCL microspheres with bound AAV vectors resulted in localized and sustained gene delivery as well as reduced spread to off-target organs compared to a vector solution. This cys-AAVR-PCL system is thus an effective approach for biomaterial-based AAV gene delivery for a broad range of therapeutic applications
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