Power Plant Economic Analysis: Maximizing Lifecycle Profitability by Simulating Preliminary Design Solutions of Steam-Cycle Conditions

Many existing financial models for power plants chose a design based on the maximum thermal efficiency excluding the operational (OPEX) and capital (CAPEX) cost variations of technical factors. These factors are often fixed because including them in financial assessments can be burdensome and it is assumed that maximum efficiency equals maximum profit. However, this assumption may not always be right. Through 19,440 power plant steam-cycle design solutions and their associated OPEX and CAPEX, this study found the eighth most thermally-efficient solution to be $1.284 M more profitable than the traditional thermally-optimized design solution. As such, this paper presents a model incorporating technical factors through parametric estimation by minimizing the burden on decision makers. While this may reduce precision, it allows for quick cost assessments across differing design solutions. The data for model development was collected from a Korean-constructed, operational 600 MW coal-fired power plant in the Philippines. Using the Thermoflex software, nearly all design configurations' heat rate outputs are simulated. Profitability is then optimized based on the resultant design configuration's impact on revenue and CAPEX and OPEX costs. The simulation inputs included variables found to be most impactful on the steam generated power efficiency per existing literature. Lastly, the model includes an assessment of cost impacts among recent environmental regulations by incorporating carbon tax costs and a sensitivity analysis. The economic analysis model discussed in this paper is non-existent in current literature and will aid the power-plant project investment industry through their project feasibility analyses.112sciescopu

Correlated normal state fermiology and topological superconductivity in UTe2

UTe2 is a promising candidate for spin-triplet superconductors, in which a paramagnetic normal state becomes superconducting due to spin fluctuations. The subsequent discovery of various unusual superconducting properties has promoted the use of UTe2 as an exciting playground to study unconventional superconductivity, but fathoming the normal state fermiology and its influence on the superconductivity still requires further investigation. Here, we theoretically show that electron correlation induces a dramatic change in the normal state fermiology with an emergent correlated Fermi surface (FS) driven by Kondo resonance at low temperatures. This emergent correlated FS can account for various unconventional superconducting properties in a unified way. In particular, the geometry of the correlated FS can naturally host topological superconductivity in the presence of odd-parity pairings, which become the leading instability due to strong ferromagnetic spin fluctuations. Moreover, two pairs of odd-parity channels appear as accidentally degenerate solutions, which can naturally explain the multicomponent superconductivity with broken time-reversal symmetry. Interestingly, the resulting time-reversal breaking superconducting state is a Weyl superconductor in which Weyl points migrate along the correlated FS as the relative magnitude of nearly degenerate pairing solutions varies. We believe that the correlated normal state fermiology we discovered provides a unified platform to describe the unconventional superconductivity in UTe2.Comment: 13 pages, 4 figures and 1 table in the main text, and 10 figures and 1 table in the Supplementary Informatio

Development of an optimum pre-founded column system for top-down construction

In this work, circular concrete-filled steel tubular (CCFT) columns, rather than the more popular H-shaped columns, were suggested as pre-founded columns for top-down construction. In addition, a novel shear connection system with headed stud shear connectors between the CCFT columns and the flat slabs was developed. It was noted that a CCFT column with a design compressive strength similar to that of an H-shaped column without consideration of length effects can be easily installed, even into a smaller borehole. Furthermore, compared to the H-shaped column, less steel is required for the CCFT column. It was shown that the amount of steel needed can be reduced by decreasing the wall thicknesses or diameters of the CCFT column depending on the exposed length of the column during excavation. The fillet-welded joint of the developed shear connector system was also tested before its in-situ application. The test results revealed that the joint possessed sufficient shear and deformation capacities. The CCFT column with the developed shear connection system was ultimately applied to an actual top-down construction process. The good constructability of the CCFT column system and reductions in construction costs and time were confirmed

Increased Antiangiogenic Effect by Blocking CCL2-dependent Macrophages in a Rodent Glioblastoma Model: Correlation Study with Dynamic Susceptibility Contrast Perfusion MRI

When glioblastoma multiforme (GBM) is treated with anti-vascular endothelial growth factor (VEGF) agents, it commonly exhibits tumor progression due to the development of resistance, which results in a dismal survival rate. GBM tumors contain a large number of monocytes/macrophages, which have been shown to be resistant to the effects of bevacizumab. It has been reported that tumor-associated macrophages (TAMS) promote resistance to bevacizumab treatment. Therefore, it is important to target TAMs in the GBM microenvironment. TAMs, which depend on chemokine ligand 2 (CCL2) for differentiation and survival, induce the expression of proangiogenic factors such as VEGF. Dynamic susceptibility contrast (DSC)-MR imaging is an advanced technique that provides information on tumor blood volume and can potentially predict the response to several treatments, including anti-angiogenic agents such as bevacizumab, in human GBM. In this study, we used a CCL2 inhibitor, mNOX-E36, to suppress the recruitment of TAMs in a CCL2-expressing rat GBM model and investigated the effect of combination therapy with bevacizumab using DSC-MR imaging. We demonstrated that the inhibition of CCL2 blocked macrophage recruitment and angiogenesis, which resulted in decreased tumor volume and blood volume in CCL2-expressing GBM in a rat model. Our results provide direct evidence that CCL2 expression can increase the resistance to bevacizumab, which can be assessed noninvasively with the DSC-MR imaging technique. This study shows that the suppression of CCL2 can play an important role in increasing the efficacy of anti-angiogenic treatment in GBM by inhibiting the recruitment of CCL2-dependent macrophages. © The Author(s) 201

MicroRNA-143 and-145 modulate the phenotype of synovial fibroblasts in rheumatoid arthritis

Fibroblast-like synoviocytes (FLSs) constitute a major cell subset of rheumatoid arthritis (RA) synovia. Dysregulation of microRNAs (miRNAs) has been implicated in activation and proliferation of RA-FLSs. However, the functional association of various miRNAs with their targets that are characteristic of the RA-FLS phenotype has not been globally elucidated. In this study, we performed microarray analyses of miRNAs and mRNAs in RA-FLSs and osteoarthritis FLSs (OA-FLSs), simultaneously, to validate how dysregulated miRNAs may be associated with the RA-FLS phenotype. Global miRNA profiling revealed that miR-143 and miR-145 were differentially upregulated in RA-FLSs compared to OA-FLSs. miR-143 and miR-145 were highly expressed in independent RA-FLSs. The miRNA-target prediction and network model of the predicted targets identified insulin-like growth factor binding protein 5 (IGFBP5) and semaphorin 3A (SEMA3A) as potential target genes downregulated by miR-143 and miR-145, respectively. IGFBP5 level was inversely correlated with miR-143 expression, and its deficiency rendered RA-FLSs more sensitive to TNFα stimulation, promoting IL-6 production and NF-κB activity. Moreover, SEMA3A was a direct target of miR-145, as determined by a luciferase reporter assay, antagonizing VEGF165-induced increases in the survival, migration and invasion of RA-FLSs. Taken together, our data suggest that enhanced expression of miR-143 and miR-145 renders RA-FLSs susceptible to TNFα and VEGF165 stimuli by downregulating IGFBP5 and SEMA3A, respectively, and that these miRNAs could be therapeutic targets. © 2017 KSBMB4

Production of Transgenic Cloned Miniature Pigs with Membrane-bound Human Fas Ligand (FasL) by Somatic Cell Nuclear Transfer

Cell-mediated xenograft rejection, including NK cells and CD8+ CTL, is a major obstacle in successful pig-to-human xenotransplantation. Human CD8+ CTL and NK cells display high cytotoxicity for pig cells, mediated at least in part by the Fas/FasL pathway. To prevent cell-mediated xenocytotoxicity, a membrane-bound form of human FasL (mFasL) was generated as an inhibitor for CTL and NK cell cytotoxicity that could not be cleaved by metalloproteinase to produce putative soluble FasL. We produced two healthy transgenic pigs harboring the mFasL gene via somatic cell nuclear transfer (SCNT). In a cytotoxicity assay using transgenic clonal cell lines and transgenic pig ear cells, the rate of CD8+ CTL-mediated cytotoxicity was significantly reduced in transgenic pig's ear cells compared with that in normal minipig fetal fibroblasts. Our data indicate that grafts of transgenic pigs expressing membrane-bound human FasL control the cellular immune response to xenografts, creating a window of opportunity to facilitate xenograft survival