Evaluation and comparison of a flumethrin-imidacloprid collar and repeated monthly treatments of fipronil/(s)-methoprene to control flea, Ctenocephalides f. felis, infestations on cats for eight months

Citation: Dryden, M. W., Smith, V., Davis, W. L., Settje, T., & Hostetler, J. (2016). Evaluation and comparison of a flumethrin-imidacloprid collar and repeated monthly treatments of fipronil/(s)-methoprene to control flea, Ctenocephalides f. felis, infestations on cats for eight months. Parasites & Vectors, 9, 6. doi:10.1186/s13071-016-1575-5Background: This controlled laboratory study was designed to evaluate the efficacy of the 10 % imidacloprid/4.5 % flumethrin collar (Seresto (R), Bayer Animal Health) against fleas (Ctenocephalides f. felis) on cats, when compared to fipronil (9.8 % w/w)/(s)-methoprene (11.8 % w/w) topical spot-on formulation (Frontline (R) Plus for Cats and Kittens, Merial). Methods: Thirty cats were randomized into three groups of ten animals based on pre-treatment flea counts: Group 1: imidacloprid/flumethrin collar; Group 2: fipronil/(s)-methoprene topical spot-on and Group 3: non-treated controls. The imidacloprid/flumethrin collars were applied one time on Day 0, while the fipronil/(s)-methoprene spot-on was administered every 30 days from Day 0 through Day 210. Cats were infested with 100 fleas on study days 0, 7, 14, 29, 59, 89, 119, 149, 179, 209 and 239. All flea counts were conducted by combing to remove fleas on post-treatment days 2, 8, 15, 30, 60, 90, 120, 150, 180, 210 and 240. Results: The efficacy of the imidacloprid/flumethrin collar ranged from 98.2 to 100 % for eight months. The efficacy of fipronil/(s)-methoprene spot-on ranged from 68.2 to 99.9 %. Efficacy was 98.2 %) efficacy against fleas on cats for the entire 8 month study. Monthly applications of fipronil/(s)-methoprene (Frontline (R) Plus for Cats and Kittens, Merial) generally had high, but variable (68.2 to 99.9 %) efficacy over the course of the eight month study. Based on the very high residual efficacy achieved by the imidacloprid/flumethrin collar in this study, veterinarians should expect that this collar will control and eliminate existing flea infestations on cats and in their in-home premises as long as every flea infested host is treated

Evaluation of a Dcya D(crp-cdt) Salmonella choleraesuis commercial vaccine to protect against clinical signs caused by and reduce shedding of Salmonella typhimurium in pigs

The two most common causes of Salmonellosis in swine are Salmonella choleraesuis and S. typhimurium. Salmonella typhimurium infections, most commonly seen in intensively reared weaned pigs, cause an enterocolitis of variable severity, followed by a carrier state that can last up to 28 weeks from onset. Infected pigs are believed to be the primary source of infection for other pigs and pork carcasses

Evaluation of a Dcya D(crp-cdt) Salmonella choleraesuis commercial vaccine to protect against clinical signs caused by and reduce shedding of Salmonella typhimurium in pigs

The two most common causes of Salmonellosis in swine are Salmonella choleraesuis and S. typhimurium. Salmonella typhimurium infections, most commonly seen in intensively reared weaned pigs, cause an enterocolitis of variable severity, followed by a carrier state that can last up to 28 weeks from onset. Infected pigs are believed to be the primary source of infection for other pigs and pork carcasses.</p

Large-Scale Electron Correlation Calculations: Rank-Reduced Full Configuration Interaction

We present the rank-reduced full configuration interaction (RR-FCI) method, a variational approach for the calculation of extremely large full configuration interaction (FCI) wave functions. In this report, we show that RR-FCI can provide ground state singlet and triplet energies within kcal/mol accuracy of full CI (FCI) with computational effort scaling as the square root of the number of determinants in the CI space (compared to conventional FCI methods which scale linearly with the number of determinants). Fast graphical processing unit (GPU) accelerated projected \u3c3 = Hc matrix-vector product formation enables calculations with configuration spaces as large as 30 electrons in 30 orbitals, corresponding to an FCI calculation with over 2.4 7 1016 configurations. We apply this method in the context of complete active space configuration interaction calculations to acenes with 2-5 aromatic rings, comparing absolute energies against FCI when possible and singlet/triplet excitation energies against both density matrix renormalization group (DMRG) and experimental results. The dissociation of molecular nitrogen was also examined using both FCI and RR-FCI. In each case, we found that RR-FCI provides a low cost alternative to FCI, with particular advantages when relative energies are desired