4,728 research outputs found
New Results From CLEO and BES
Latest experimental results from BES in the charmonium mass region, and those
from CLEO in the bottomonium and charmonium spectroscopy are reviewed.Comment: 12 pages, 12 figures, Presented at First Meeting of the APS Topical
Group on Hadron Physics, Fermilab, Batavia, Illinois, Oct 24-26, 200
Variability of Objectively Measured Sedentary Behavior
The primary purpose of this study was to evaluate variability of sedentary behavior (SB) throughout a 7-d measurement period and to determine if G7 d of SB measurement would be comparable with the typical 7-d measurement period. Methods: Retrospective data from Ball State University_s Clinical Exercise Physiology Laboratory on 293 participants (99 men, 55 T 14 yr, body mass index = 29 T 5 kgImj2; 194 women, 51 T 12 yr, body mass index = 27 T 7 kgImj2) with seven consecutive days of data collected with ActiGraph accelerometers were analyzed (ActiGraph, Fort Walton Beach, FL). Time spent in SB (either G100 counts per minute or G150 counts per minute) and breaks in SB were compared between days and by sex using a two-way repeated-measures ANOVA. Stepwise regression was performed to determine if G7 d of SB measurement were comparable with the 7-d method, using an adjusted R2 of Q0.9 as a criterion for equivalence. Results: There were no differences in daily time spent in SB between the 7 d for all participants. However, there was a significant interaction between sex and days, with women spending less time in SB on both Saturdays and Sundays than men when using the 100 counts per minute cut-point. Stepwise regression showed using any 4 d would be comparable with a 7-d measurement (R2 9 0.90). Conclusions: When assessed over a 7-d measurement period, SB appears to be very stable from day to day, although there may be some small differences in time spent in SB and breaks in SB between men and women, particularly on weekend days. The stepwise regression analysis suggests that a measurement period as short as 4 d could provide comparable data (91% of variance) with a 1-wk assessment. Shorter assessment periods would reduce both researcher and subject burden in data collection
New directions in EEG measurement: an investigation into the fidelity of electrical potential sensor signals
Low frequency noise performance is the key indicator in determining the signal to noise ratio of a capacitively coupled sensor when used to acquire electroencephalogram signals. For this reason, a prototype Electric Potential Sensor device based on an auto-zero operational amplifier has been developed and evaluated. The absence of 1/f noise in these devices makes them ideal for use with signal frequencies ~10 Hz or less. The active electrodes are designed to be physically and electrically robust and chemically and biochemically inert. They are electrically insulated (anodized) and have diameters of 12 mm or 18 mm. In both cases, the sensors are housed in inert stainless steel machined housings with the electronics fabricated in surface mount components on a printed circuit board compatible with epoxy potting compounds. Potted sensors are designed to be immersed in alcohol for sterilization purposes. A comparative study was conducted with a commercial wet gel electrode system. These studies comprised measurements of both free running electroencephalogram and Event Related Potentials. Quality of the recorded electroencephalogram was assessed using three methods of inspection of raw signal, comparing signal to noise ratios, and Event Related Potentials noise analysis. A strictly comparable signal to noise ratio was observed and the overall conclusion from these comparative studies is that the noise performance of the new sensor is appropriate
Active interoceptive inference and the emotional brain
We review a recent shift in conceptions of interoception and its relationship to hierarchical inference in the brain. The notion of interoceptive inference means that bodily states are regulated by autonomic reflexes that are enslaved by descending predictions from deep generative models of our internal and external milieu. This re-conceptualization illuminates several issues in cognitive and clinical neuroscience with implications for experiences of selfhood and emotion. We first contextualize interoception in terms of active (Bayesian) inference in the brain, highlighting its enactivist (embodied) aspects. We then consider the key role of uncertainty or precision and how this might translate into neuromodulation. We next examine the implications for understanding the functional anatomy of the emotional brain, surveying recent observations on agranular cortex. Finally, we turn to theoretical issues, namely, the role of interoception in shaping a sense of embodied self and feelings. We will draw links between physiological homoeostasis and allostasis, early cybernetic ideas of predictive control and hierarchical generative models in predictive processing. The explanatory scope of interoceptive inference ranges from explanations for autism and depression, through to consciousness. We offer a brief survey of these exciting developments
Reconstructing a Z' Lagrangian using the LHC and low-energy data
We study the potential of the LHC and future low-energy experiments to
precisely measure the underlying model parameters of a new Z' boson. We
emphasize the complimentary information obtained from both on- and off-peak LHC
dilepton data, from the future Q-weak measurement of the weak charge of the
proton, and from a proposed measurement of parity violation in low-energy
Moller scattering. We demonstrate the importance of off-peak LHC data and
Q-weak for removing sign degeneracies between Z' couplings that occur if only
on-peak LHC data is studied. A future precision measurement of low-energy
Moller scattering can resolve a scaling degeneracy between quark and lepton
couplings that remains after analyzing LHC dilepton data, permitting an
extraction of the individual Z' couplings rather than combinations of them. We
study how precisely Z' properties can be extracted for LHC integrated
luminosities ranging from a few inverse femtobarns to super-LHC values of an
inverse attobarn. For the several example cases studied with M_Z'=1.5 TeV, we
find that coupling combinations can be determined with relative uncertainties
reaching 30% with 30 fb^-1 of integrated luminosity, while 50% is possible with
10 fb^-1. With SLHC luminosities of 1 ab^-1, we find that products of quark and
lepton couplings can be probed to 10%.Comment: 36 pages, 17 figure
Recommended from our members
Oncogenic R132 IDH1 Mutations Limit NADPH for De Novo Lipogenesis through (D)2-Hydroxyglutarate Production in Fibrosarcoma Sells.
Neomorphic mutations in NADP-dependent isocitrate dehydrogenases (IDH1 and IDH2) contribute to tumorigenesis in several cancers. Although significant research has focused on the hypermethylation phenotypes associated with (D)2-hydroxyglutarate (D2HG) accumulation, the metabolic consequences of these mutations may also provide therapeutic opportunities. Here we apply flux-based approaches to genetically engineered cell lines with an endogenous IDH1 mutation to examine the metabolic impacts of increased D2HG production and altered IDH flux as a function of IDH1 mutation or expression. D2HG synthesis in IDH1-mutant cells consumes NADPH at rates similar to de novo lipogenesis. IDH1-mutant cells exhibit increased dependence on exogenous lipid sources for in vitro growth, as removal of medium lipids slows growth more dramatically in IDH1-mutant cells compared with those expressing wild-type or enzymatically inactive alleles. NADPH regeneration may be limiting for lipogenesis and potentially redox homeostasis in IDH1-mutant cells, highlighting critical links between cellular biosynthesis and redox metabolism
Nonlinear dynamics of small-scale Alfv\'en waves
We study the nonlinear evolution of very oblique small-scale Alfv\'en waves
with . At these scales, the waves become significantly
compressive, unlike in MHD, due to the Hall term in the equations. We
demonstrate that when frequencies are small compared to the ion gyrofrequency
and amplitudes small compared to unity, no new nonlinear interaction appears
due to the Hall term alone at the lowest non-trivial order, even when . However, at the second non-trivial order, we discover that the
Hall physics leads to a slow but resonant nonlinear interaction between
co-propagating Alfv\'en waves, an inherently 3D effect. Including the effects
of finite temperature, finite frequency, and electron inertia, the two-fluid
Alfv\'en wave also becomes dispersive once one or more of ,
, or becomes significant: for oblique waves at
low as studied here, this can be at a much smaller scale than . We
show that the timescale for one-dimensional steepening of two-fluid Alfven
waves is only significant at these smaller dispersive scales, and also derive
an expression for the amplitude of driven harmonics of a primary wave.
Importantly, both new effects are absent in gyrokinetics and other commonly
used reduced two-fluid models. Our calculations have relevance for the
interpretation of laboratory Alfv\'en wave experiments, as well as shedding
light on the physics of turbulence in the solar corona and inner solar wind,
where the dominant nonlinear interaction between counter-propagating waves is
suppressed, allowing these new effects to become important.Comment: 17 pages; submitted to Physics of Plasma
Star formation and UV colors of the brightest Cluster Galaxies in the representative XMM-Newton Cluster Structure Survey
We present UV broadband photometry and optical emission-line measurements for
a sample of 32 Brightest Cluster Galaxies (BCGs) in clusters of the
Representative XMM-Newton Cluster Structure Survey (REXCESS) with z =
0.06-0.18. The REXCESS clusters, chosen to study scaling relations in clusters
of galaxies, have X-ray measurements of high quality. The trends of star
formation and BCG colors with BCG and host properties can be investigated with
this sample. The UV photometry comes from the XMM Optical Monitor, supplemented
by existing archival GALEX photometry. We detected H\alpha and forbidden line
emission in 7 (22%) of these BCGs, in optical spectra. All of the emission-line
BCGs occupy clusters classified as cool cores, for an emission-line incidence
rate of 70% for BCGs in cool core clusters. Significant correlations between
the H\alpha equivalent widths, excess UV production in the BCG, and the
presence of dense, X-ray bright intracluster gas with a short cooling time are
seen, including the fact that all of the H\alpha emitters inhabit systems with
short central cooling times and high central ICM densities. Estimates of the
star formation rates based on H\alpha and UV excesses are consistent with each
other in these 7 systems, ranging from 0.1-8 solar masses per year. The
incidence of emission-line BCGs in the REXCESS sample is intermediate, somewhat
lower than in other X-ray selected samples (-35%), and somewhat higher than but
statistically consistent with optically selected, slightly lower redshift BCG
samples (-10-15%). The UV-optical colors (UVW1-R-4.7\pm0.3) of REXCESS BCGs
without strong optical emission lines are consistent with those predicted from
templates and observations of ellipticals dominated by old stellar populations.
We see no trend in UV-optical colors with optical luminosity, R-K color, X-ray
temperature, redshift, or offset between X-ray centroid and X-ray peak ().Comment: 19 pages, 18 figures, 6 tables. Submitted, with minor revisions, to
ApJ
Non-Carrier Nanoparticles Adjuvant ModularProtein Vaccine in a Particle-Dependent Manner
Nanoparticles are increasingly used to adjuvant vaccine formulations due to their biocompatibility, ease of manufacture and the opportunity to tailor their size, shape, and physicochemical properties. The efficacy of similarly-sized silica (Si-OH), poly (D,L-lactic-co-glycolic acid) (PLGA) and poly caprolactone (PCL) nanoparticles (nps) to adjuvant recombinant capsomere presenting antigenic M2e modular peptide from Influenza A virus (CapM2e) was investigated in vivo. Formulation of CapM2e with Si-OH or PLGA nps significantly boosted the immunogenicity of modular capsomeres, even though CapM2e was not actively attached to the nanoparticles prior to injection (i.e., formulation was by simple mixing). In contrast, PCL nps showed no significant adjuvant effect using this simple-mixing approach. The immune response induced by CapM2e alone or formulated with nps was antibody-biased with very high antigen-specific antibody titer and less than 20 cells per million splenocytes secreting interferon gamma. Modification of silica nanoparticle surface properties through amine functionalization and pegylation did not lead to significant changes in immune response. This study confirms that simple mixing-based formulation can lead to effective adjuvanting of antigenic protein, though with antibody titer dependent on nanoparticle physicochemical properties
- …