59 research outputs found

    The impact of gatekeeper training for suicide prevention on university resident assistants

    Get PDF
    Abstract: Resident assistants (RAs) can serve as important suicide prevention gatekeepers. The purpose of the study was to determine if training improved RAs' crisis communications skills and suiciderelated knowledge and to determine if the knowledge elements predicted crisis communications skills. New RAs showed significant improvement in all areas from pretest to posttest, whereas returning RAs showed no significant increase in any of the areas. None of the knowledge areas predicted communications skills for either group

    Nanostructured 3D Constructs Based on Chitosan and Chondroitin Sulphate Multilayers for Cartilage Tissue Engineering

    Get PDF
    Nanostructured three-dimensional constructs combining layer-by-layer technology (LbL) and template leaching were processed and evaluated as possible support structures for cartilage tissue engineering. Multilayered constructs were formed by depositing the polyelectrolytes chitosan (CHT) and chondroitin sulphate (CS) on either bidimensional glass surfaces or 3D packet of paraffin spheres. 2D CHT/CS multi-layered constructs proved to support the attachment and proliferation of bovine chondrocytes (BCH). The technology was transposed to 3D level and CHT/CS multi-layered hierarchical scaffolds were retrieved after paraffin leaching. The obtained nanostructured 3D constructs had a high porosity and water uptake capacity of about 300%. Dynamical mechanical analysis (DMA) showed the viscoelastic nature of the scaffolds. Cellular tests were performed with the culture of BCH and multipotent bone marrow derived stromal cells (hMSCs) up to 21 days in chondrogenic differentiation media. Together with scanning electronic microscopy analysis, viability tests and DNA quantification, our results clearly showed that cells attached, proliferated and were metabolically active over the entire scaffold. Cartilaginous extracellular matrix (ECM) formation was further assessed and results showed that GAG secretion occurred indicating the maintenance of the chondrogenic phenotype and the chondrogenic differentiation of hMSCs

    Fourier Transform Infrared Spectroscopic Imaging and Multivariate Regression for Prediction of Proteoglycan Content of Articular Cartilage

    Get PDF
    Fourier Transform Infrared (FT-IR) spectroscopic imaging has been earlier applied for the spatial estimation of the collagen and the proteoglycan (PG) contents of articular cartilage (AC). However, earlier studies have been limited to the use of univariate analysis techniques. Current analysis methods lack the needed specificity for collagen and PGs. The aim of the present study was to evaluate the suitability of partial least squares regression (PLSR) and principal component regression (PCR) methods for the analysis of the PG content of AC. Multivariate regression models were compared with earlier used univariate methods and tested with a sample material consisting of healthy and enzymatically degraded steer AC. Chondroitinase ABC enzyme was used to increase the variation in PG content levels as compared to intact AC. Digital densitometric measurements of Safranin O –stained sections provided the reference for PG content. The results showed that multivariate regression models predict PG content of AC significantly better than earlier used absorbance spectrum (i.e. the area of carbohydrate region with or without amide I normalization) or second derivative spectrum univariate parameters. Increased molecular specificity favours the use of multivariate regression models, but they require more knowledge of chemometric analysis and extended laboratory resources for gathering reference data for establishing the models. When true molecular specificity is required, the multivariate models should be used

    Abschlussbericht zum Forschungsvorhaben der Stiftung Volkswagen

    No full text

    Hochtemperatur-Gasturbine (HTGT). Turbotech II Abschlussbericht

    No full text
    This report outlines results of MTU's workpackages. Following subjects are addressed: - Development of practical tool to be used for quick optimisation of turbomachinery bladings - Development and validation of Navier Stokes Solver for multi-stage compressors - Definition of arrangement of loudspeakers and microphones for active noise reduction tests; Analysis of respective rig tests -Development and validation of an unsteady 3D-code for calculations of compr's stall chic's - Testing of algorithm for surge detection based on data of NGV Dresden - Calculation of flutter stability in transonic flows - Development of an overall optimisation algorithm to be used for integrated design of aerothermal optimal cooled turbine blades - Secondary flow: Analysis of grid measurements and application to a three stage low speed turbine. (orig.)In diesem Bericht werden die Ergebnisse der bei MTU im Rahmen von Turbotech II durchgefuehrten Arbeiten vorgestellt und bewertet. Die Arbeiten konzentrierten sich auf folgende Schwerpunkte: - Entwicklung eines fuer die praktische Anwendung geeigneten Verfahrens zur schnellen Optimierung von Turbomaschinen - Beschaufelungen unter besonderer Beruecksichtigung des 'Strakens'. - Entwicklung und Validierung eines stationaeren Navier-Stokes-Verfahrens zur Berechnung mehrstufiger Verdichter. - Definition der Lautsprecher- und Mikrofonanordnung sowie Auswertung der Versuche zur Erprobung aktiver Massnahmen zur Laermminderung an Turbomaschinen. - Entwicklung und Validierung eines instationaeren Verfahrens zur Berechnung des Verhaltens transsonischer Verdichter mit kleinem Nabenverhaeltnis an der Stabilitaetsgrenze. - Erprobung eines Analyseverfahrens zur Pumpgrenzfrueherkennung von Hand von Daten aus dem Niedergeschwindigkeits-Windkanal der TU Dresden. - Berechnung der Flatterstabilitaet bei transsonischen Stroemungen. - Entwicklung eines Gesamt-Optimierungsalgorithmus zur integrierten Auslegung aerothermisch optimal gekuehlter Turbinenschaufeln. - Zum Thema Sekundaerstroemungen: Analyse und Uebertragung von Gittermessungen auf ein dreistufiges Niedermachzahl-Turbinenrig. (orig.)SIGLEAvailable from TIB Hannover: F02B591 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekBundesministerium fuer Bildung und Forschung, Berlin (Germany)DEGerman

    Origin, Age, and Quaternary Effects of Loeses Region in Central North Iran

    No full text
    The Quaternary mapping of central North Iran has provided the first documentation of the loess deposits of the area. The loess is derived from the adjoining flood plains and has been transported by winds over relatively short distances at low altitudes. An accumulation rate of about 12 cm/1000 years has been assumed which implies that the investigated Nowdeh loess section, Mazandaran province, spans the last 208000 years. Paleoclmatic evidence indicates the loess of central North Iran was deposited under cold, dry and windy conditions interrupted by short, warm periods represented by paleosol formation. The loess-paleosol sequence of the Nowdeh section corresponds to the Riss Glaciation, Riss-wilrm interglacial, wilrm Glaciation and the present interglacial. The reflection of world-wide paleoclimatic fluctuations in the loess record is demonstrated by a fairly good correlation with deep sea core data. Both the loess- paleosol stratigraphy and the reconstructed kd/cl (coarse silt/ clay ratio) curve seem to reflect the 20/000-year and the 100/000-year cycles which, tentatively, permit the prediction that the inception of the next windy, cold and dry phase will be in approximately 6/000 years time, while its major peak will be in 56000 years time
    • …
    corecore