110 research outputs found
First archaeointensity results from four types of ancient kilns excavated in Burkina Faso (West Africa)
Preferences and skills of Indian public sector teachers
With a sample of 700 future public sector primary teachers in India, a Discrete Choice Experiment is used to measure job preferences, particularly regarding location. General skills are also tested. Urban origin teachers and women are more averse to remote locations than rural origin teachers and men respectively. Women would require a 26-73 percent increase in salary for moving to a remote location. The results suggest that existing caste and gender quotas can be detrimental for hiring skilled teachers willing to work in remote locations. The most preferred location is home, which supports decentralised hiring, although this could compromise skills
Functional MMP-10 is required for efficient tissue repair after experimental hind limb ischemia
Whether to Hire Local Contract Teachers? Trade-Off between Skills and Preferences in India
Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium
Tumor progression alters the composition and physical properties of the extracellular matrix. Particularly, increased matrix stiffness has profound effects on tumor growth and metastasis. While endothelial cells are key players in cancer progression, the influence of tumor stiffness on the endothelium and the impact on metastasis is unknown. Through quantitative mass spectrometry, we find that the matricellular protein CCN1/CYR61 is highly regulated by stiffness in endothelial cells. We show that stiffnessâinduced CCN1 activates ÎČâcatenin nuclear translocation and signaling and that this contributes to upregulate Nâcadherin levels on the surface of the endothelium, in vitro. This facilitates Nâcadherinâdependent cancer cellâendothelium interaction. Using intravital imaging, we show that knockout of Ccn1 in endothelial cells inhibits melanoma cancer cell binding to the blood vessels, a critical step in cancer cell transit through the vasculature to metastasize. Targeting stiffnessâinduced changes in the vasculature, such as CCN1, is therefore a potential yet unappreciated mechanism to impair metastasis
Comparing Inductive and Deductive Modeling of Land Use Decisions: Principles, a Model and an Illustration from the Philippines
Determining Greenhouse Gas Emissions and Removals Associated with Land-Use and Land-Cover Change
Why is Access to Basic Services Not Inclusive? A Synthesis with a Special Focus on Developing Asia
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