Physicochemical Parameters, Mineral Composition, and Nutraceutical Properties of Ready-to-Drink Flavored-Colored Commercial Teas

The physicochemical parameters, mineral composition, and nutraceutical properties of ready-to-drink flavored-colored commercial teas were analyzed in the present study. The pH of samples was slightly acidic (3.72 to 4.11), titratable acidity was low (0.092 to 0.174%), and color parameters were wide variable (pink, yellow, brown, and red). Citrus-flavored tea obtained the highest content of manganese (0.281mg·L−1), zinc (0.069mg·L−1), magnesium (2.92mg·L−1), potassium (62.65mg·L−1), and sodium (271.74mg·L−1), while lemon-, peach-, and blueberry-flavored teas obtained the highest levels of copper (0.035mg·L−1), iron (0.246mg·L−1), and calcium (18.21mg·L−1), respectively. Citrus, lemon-, sangria-, and rose petal-flavored teas obtained the highest content in total phenols (211.56mg·L−1), total flavonoids (65.46mg·L−1), total catechins (640.79mg·L−1), and total anthocyanins (640.79mg·L−1), respectively. Lemon- and rose petal-flavored teas showed the highest and lowest antioxidant capacity levels in DPPH (1096.00 to 118.77μmolTE·L−1), ABTS (1048.84 to 232.00μmolTE·L−1), and FRAP (1269.20 to 147.70μmolTE·L−1) assays. The levels of sodium reported in labels of all samples were lower than data obtained in our analysis. Alsothelevelsobservedfortotalphenolsinblueberry-,citrus-,androsepetal-flavoredteaswerelowerthanouranalysis,buttotal phenolsoflemon-,peach-,andsangria-flavoredteaswerehigherthanthecontentreportedintheirlabels.Theresultsobtainedin thepresentworkgiveinformationtoconsumersforchoosingflavored-coloredready-to-drinkteabasedonthephysicochemical, nutritional, and nutraceutical properties

Design of good practices for the mathematical training of Kindergarten Education teachers and Primary Education teachers: Zero course in mathematics and mathematics teaching subjects.

El objetivo de este proyecto es la coordinación de las asignaturas impartidas por los profesores de la Unidad Docente de Didáctica de las Matemáticas, actualizando contenidos y prácticas de la formación de la enseñanza-aprendizaje de las matemáticas en los grados de Maestro en Educación Infantil y Primaria.The objective of this project is the coordination of the subjects that are taught by the teachers of the Unit of Didactic of Mathematics, updating contents and practices of the teaching-learning of mathematics in Kindergarten Education Teacher Degree and Primary Education Teacher DegreeDepto. de Didáctica de las Ciencias Experimentales , Sociales y MatemáticasFac. de EducaciónFALSEsubmitte

MicroMundo@UCM: Citizen Science and Service-Learning against Antibiotic Resistance from the Academic Community

Según ha establecido la OMS y la Asamblea de las Naciones Unidas, la resistencia a los antibióticos es una de las prioridades en Salud Global para el s. XXI, al mismo nivel que la preparación frente a pandemias emergentes y el desarrollo de vacunas y tratamientos frente a tuberculosis, malaria, HIV y otras enfermedades infecciosas. El abordaje de estos problemas sólo será eficaz desde la perspectiva multidisciplinar One Health (Un Mundo: Una Salud), que integra Salud Medioambiental, Animal y Humana. Desde 2016 la UCM ha sido pionera en implicar a las comunidades universitaria y preuniversitaria en la estrategia de aprendizaje activo mediante ApS “MicroMundo” (www.ucm.es/small-world-initiative), un proyecto multidisciplinar basado en ApS en el ámbito de la Biomedicina. Se trata de una adaptación al ApS de la estrategia internacional de studentsourcing Tiny Earth (www.tinyearthnet.org). MicroMundo implica a estudiantes de ESO y Bachillerato a participar como investigadores en un proyecto real para el descubrimiento de nuevos antibióticos a partir de muestras de suelos. El objetivo final del servicio es acercar la cultura científica, la perspectiva One Health y la investigación biomédica a la sociedad. Para ello, colaboramos con una red de colegios e institutos de la Comunidad de Madrid. Un objetivo adicional es fomentar la vocación por Grados STEM y por la I+D. Para lograr estos objetivos, los estudiantes universitarios, objeto del aprendizaje, se responsabilizan de facilitar a los jóvenes estudiantes el entrenamiento y material necesarios para llevar a cabo los experimentos, así como dirigir el trabajo de investigación y diversas estrategias de divulgación hacia la comunidad. El éxito del proyecto en la UCM ha inspirado su implementación en más de 30 universidades en España y Portugal y ha merecido el Premio PRAN 2021 a la comunicación y sensibilización de la población sobre la resistencia a los antibióticos. En esta publicación presentamos la memoria final del proyecto MicroMundo@UCM realizado durante el curso 2022-23 en 33 centros educativos de la Comunidad de Madrid.Oficina de Aprendizaje-Servicio UCMConvenio MSD España-UCMDepto. de Microbiología y ParasitologíaDepto. de Genética, Fisiología y MicrobiologíaDepto. de Sanidad AnimalDepto. de Nutrición y Ciencia de los AlimentosDepto. de Bioquímica y Biología MolecularFac. de FarmaciaFac. de Ciencias BiológicasFac. de VeterinariaTRUEunpu

Switching TNF antagonists in patients with chronic arthritis: An observational study of 488 patients over a four-year period

The objective of this work is to analyze the survival of infliximab, etanercept and adalimumab in patients who have switched among tumor necrosis factor (TNF) antagonists for the treatment of chronic arthritis. BIOBADASER is a national registry of patients with different forms of chronic arthritis who are treated with biologics. Using this registry, we have analyzed patient switching of TNF antagonists. The cumulative discontinuation rate was calculated using the actuarial method. The log-rank test was used to compare survival curves, and Cox regression models were used to assess independent factors associated with discontinuing medication. Between February 2000 and September 2004, 4,706 patients were registered in BIOBADASER, of whom 68% had rheumatoid arthritis, 11% ankylosing spondylitis, 10% psoriatic arthritis, and 11% other forms of chronic arthritis. One- and two-year drug survival rates of the TNF antagonist were 0.83 and 0.75, respectively. There were 488 patients treated with more than one TNF antagonist. In this situation, survival of the second TNF antagonist decreased to 0.68 and 0.60 at 1 and 2 years, respectively. Survival was better in patients replacing the first TNF antagonist because of adverse events (hazard ratio (HR) for discontinuation 0.55 (95% confidence interval (CI), 0.34-0.84)), and worse in patients older than 60 years (HR 1.10 (95% CI 0.97-2.49)) or who were treated with infliximab (HR 3.22 (95% CI 2.13-4.87)). In summary, in patients who require continuous therapy and have failed to respond to a TNF antagonist, replacement with a different TNF antagonist may be of use under certain situations. This issue will deserve continuous reassessment with the arrival of new medications. © 2006 Gomez-Reino and Loreto Carmona; licensee BioMed Central Ltd