Type I necrotising fasciitis of heel in a diabetic patient

Necrotising fasciitis is a potentially fatal clinical disease caused by infection with various bacteria. Diabetes mellitus, one of the predisposing factors for necrotising fasciitis is also an important factor in the progression of the illness by increasing its morbidity and mortality rate. In this case report, a 54 year old diabetic woman with type-I necrotising fasciitis of the heel was treated with extensive debridments, broad spectrum antimicrobial therapy and intensive regulation of blood glucose levels. The resulting new positive data pertaining to the morbidity and mortality of this severe disease suggest that the old management of this disease should be re- examined

Spinal cord compression secondary to extramedullary hematopoiesis in thalassemia intermedia

Extramedullary hematopoiesis associated with thalassemia causing spinal cord compression is an extremely rare event in the course of the disease. Documentation with an imaging technique, such as MRI, is mandatory. A patient with thalassemia intermedia, who developed paraparesis in spite of transfusion, underwent surgical decompression. Rapid neurological improvement was observed postoperatively and this neurological condition was protected with adequate hemoglobin level. Management of these patients remains controversial. Various modes of therapy such as surgical decompression, radiotherapy, and transfusion are discussed and the related literature is reviewed

Sağlıklı kişilerde yaş gruplarına göre oral glukoz tolerans testi sonuçları

Bu tezin, veri tabanı üzerinden yayınlanma izni bulunmamaktadır. Yayınlanma izni olmayan tezlerin basılı kopyalarına Üniversite kütüphaneniz aracılığıyla (TÜBESS üzerinden) erişebilirsiniz.[Abstarct Not Available

Postmenopausal Women in Denizli Province

Objective: Osteoporosis is an important clinical condition frequently seen in postmenopausal women. It is the major cause of vertebrael and hip fractures. The incidence of osteoporotic fractures has been increasing and half of the elderly female population in most Western as well as Asian countries has been affected. The aim of this study was to determine the postmenopausal osteoporosis rate and evaluate the relationship between osteoporosis and various risk factors in postmenopausal women living in the central and rural areas of Denizli. Material and Methods: Subjects were selected randomly among postmenopausal women who were enrolled in Village Health Centers of Denizli Provincial Directorate of,Health by public announcements. We evaluated 1100 postmenopausal women out of 16113 women, aged 45-80 years. The bone mineral density of the patients was measured by quantitative ultrasound of the tibia. Subjects with T scores lower than -2.5 SD were diagnosed as osteoporosis according to the World Health Organization criteria. Results: The rates of osteoporosis in various areas ranged between 19.8% and 53.9% (mean 36.8%). The subjects were divided into two groups as with osteoporosis and without osteoporosis. Average menarche age was greater in the osteoporotic group. The subjects who had taken hormone replacement therapy (HRT) had lower osteoporosis rate. Subjects with osteoporosis had lower exercise score and had lack of sun exposure due to covering. A positive correlation was found between osteoporosis age and the duration of menopause. Conclusion: We found that the incidence of osteoporosis among postmenopausal women was very high especially in rural areas of Denizli. Age, duration of menopause, age of menarche and multiparity appeared to be important risk factors in development of osteoporosis. However, HRT, physical activity and sun exposure could prevent osteoporosis. Understanding the epidemiology and fracture risk of osteoporosis may ultimately aid in reducing the public health burden of this common disorder

The results of Pamukkale Osteoporosis Study in Turkey

https://stars.library.ucf.edu/cfm-ch-register-vol13/1239/thumbnail.jp

Blink reflex in hyperthyroidism

Although there are studies regarding the effects of thyroid hormones on some neurologic reflexes, literature lacks knowledge of the effects of thyroid hormones on blink reflex circuits. To understand the behaviour of excess thyroid hormone on this circuit that involves synapses in brainstem, we studied electrically elicited blink reflexes of 7 patients with hyperthyroidism, 8 patients with hyperthyroidism who were under therapy and 14 volunteers as control by electroneuromyograph. Mean values of the latencies and amplitudes of the R1 and R2 responses were not statistically different between groups, while the duration of R2 response and controlateral R2 response were found shorter in patients with hyperthyroidism comparing to the patients under therapy and controls. We have thought that these findings might reflect the inhibitor effect of the excess thyroid hormone on polysynaptic reflex arc of the blink response

Correlation of abdominal fat accumulation and liver steatosis: importance of ultrasonographic and anthropometric measurements.

PURPOSE: This study has two objectives: (1) using ultrasound (US) as a tool for measuring subcutaneous (S) and intra-abdominal; preperitoneal (P) and visceral (V) fat thickness. (2) Assessing the relationship between selected anthropometrical variables and US-measured S, P and V fat also evaluating the contribution of abdominal fat accumulation in development of liver steatosis. METHODS AND MATERIALS: Sixty-eight obese patients (aged 43.9+/-9.3 years) and 40 non-obese subjects (aged 34.03+/-9.0 years) were recruited to this study. Height, weight (W), waist (WC) and hip circumferences were measured. Body mass index (BMI) and waist to hip ratio (WHR) were calculated. A linear-array probe (7.5 MHz) was used to measure S and P. A convex-array probe (3.5 MHz) was used for measuring V and assessing liver fatty infiltration. RESULTS: In 45 (66%) patients, there were diffuse liver fatty changes. Liver steatosis showed significant correlation with V (r=0.57), P (r=0.38) and S (r=0.37). It also correlated with W (r=0.52), BMI (r=0.6), WC (r=0.45) (P<0.0001). V positively correlated with BMI (r=0.62), W (r=0.55), WC (r=0.52) and WHR (r=0.33). P correlated with WC (r=0.29), WHR (r=0.36) and W (r=0.34), but not with BMI, height and age. A significant correlation was found between S and BMI (r=0.73), W (r=0.65), and WC (r=0.57) (P<0.0001). CONCLUSION: Obese patients showed thicker S, P, and V. Liver steatosis correlates significantly with both anthropometrical data; BMI, WHR, WC, and W, and with abdominal V, P, and S fat. V fat can be used as a good predictor for the possibility of different metabolic disorders and liver disturbances as steastosis

Cranial magnetic resonance imaging of Wolfram (DIDMOAD) syndrome

Wolfram syndrome is a rare neurodegenerative disorder characterized by diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD). A wide spectrum of abnormalities of the central nervous system, urinary tract and endocrine glands is also observed. We report cranial MRI findings in a 32-year-old female patient with Wolfram syndrome. In addition to the classical features, including absence of the normal high signal of the neurohypophysis, atrophy of visual pathways, the brainstem, cerebellum and cerebral cortex, we observed bilateral hyperintensity on proton density- and T2- weighted images related to the optic radiations in the periventricular white matter of the temporal and parieto-occipital lobes, which may reflect gliosis pathologically