Prenatal radiation exposure

Pregnant women may be exposed to nonionizing, ionizing radiation and contrast media via diagnostic or therapeutic procedures and workplace exposure. When computed tomography or magnetic resonance imaging is performed on a pregnant woman, the effects of exposure to radiation, high magnetic fields and contrast media, which can be risky for a fetus, should be considered. Nonionizing radiation that is not significantly risky for a fetus includes microwave, ultrasound, radio frequency and electromagnetic waves, while ionizing radiation that can be teratogenic, carcinogenic or mutagenic includes particles and electromagnetic radiation. The effects of radiation are associated with the level of exposure and stage of fetal development. Organogenesis (two to seven weeks after conception) and the early fetal period (eight to fifteen weeks after conception) are the most sensitive stages for a fetus. Noncancerous health effects have not been determined at any stage of gestation with less than 50 mGy (5 rad) exposure dose of ionizing radiation. Higher exposure levels may lead to spontaneous abortion, growth restriction, and mental retardation. The risk of cancer is increased regardless of the dose. Although the use of iodinated contrast media is generally thought to be safe during pregnancy, the risk of fetal hypothyroidism should be considered and it should be used only when necessary. The use of gadolinium-based contrast media during pregnancy is controversial because of the lack of clinical data. The purpose of this article is to review the existing literature regarding the prenatal radiation exposure and to discuss fetal risk of radiation

Magnetic resonance imaging of benign prostatic hyperplasia

Benign prostatic hyperplasia (BPH) is a common condition in middle-aged and older men and negatively affects the quality of life. An ultrasound classification for BPH based on a previous pathologic classification was reported, and the types of BPH were classified according to different enlargement locations in the prostate. Afterwards, this classification was demonstrated using magnetic resonance imaging (MRI). The classification of BPH is important, as patients with different types of BPH can have different symptoms and treatment options. BPH types on MRI are as follows: type 0, an equal to or less than 25 cm3 prostate showing little or no zonal enlargements; type 1, bilateral transition zone (TZ) enlargement; type 2, retrourethral enlargement; type 3, bilateral TZ and retrourethral enlargement; type 4, pedunculated enlargement; type 5, pedunculated with bilateral TZ and/or retrourethral enlargement; type 6, subtrigonal or ectopic enlargement; type 7, other combinations of enlargements. We retrospectively evaluated MRI images of BPH patients who were histologically diagnosed and presented the different types of BPH on MRI. MRI, with its advantage of multiplanar imaging and superior soft tissue contrast resolution, can be used in BPH patients for differentiation of BPH from prostate cancer, estimation of zonal and entire prostatic volumes, determination of the stromal/glandular ratio, detection of the enlargement locations, and classification of BPH types which may be potentially helpful in choosing the optimal treatment

Spin-echo and diffusion-weighted MRI in differentiation between progressive massive fibrosis and lung cancer

PURPOSEWe aimed to investigate the value of magnetic resonance imaging (MRI)-based parameters in differentiating between progressive massive fibrosis (PMF) and lung cancer.METHODSThis retrospective study included 60 male patients (mean age, 67.0±9.0 years) with a history of more than 10 years working in underground coal mines who underwent 1.5 T MRI of thorax due to a lung nodule/mass suspicious for lung cancer on computed tomography. Thirty patients had PMF, and the remaining ones had lung cancer diagnosed histopathologically. The sequences were as follows: coronal single-shot turbo spin echo (SSH-TSE), axial T1- and T2-weighted spin-echo (SE), balanced turbo field echo, T1-weighted high-resolution isotropic volume excitation, free-breathing and respiratory triggered diffusion-weighted imaging (DWI). The patients’ demographics, lesion sizes, and MRI‐derived parameters were compared between the patients with PMF and lung cancer.RESULTSApparent diffusion coefficient (ADC) values of DWI and respiratory triggered DWI, signal intensities on T1-weighted SE, T2-weighted SE, and SSH-TSE imaging were found to be significantly different between the groups (p < 0.001, for all comparisons). Median ADC values of free-breathing DWI in patients with PMF and cancer were 1.25 (0.93–2.60) and 0.76 (0.53–1.00) (× 10-3 mm2/s), respectively. Most PMF lesions were predominantly iso- or hypointense on T1-weighted SE, T2-weighted SE, and SSH-TSE, while most malignant ones predominantly showed high signal intensity on these sequences.CONCLUSIONMRI study including SE imaging, specially T1-weighted SE imaging and ADC values of DWI can help to distinguish PMF from lung cancer

Rapid progression of COVID-19 pneumonia to extensive fibrosis assessed with 3D volumetric CT

[No Abstract Available

Clinical significance of renal cortical thickness in patients with chronic kidney disease

WOS: 000429225000007PubMed ID: 28618770Purpose: The aim of this study was to evaluate the correlations between laboratory findings and ultrasonographic measurements of renal length and cortical thickness in patients receiving follow-up for chronic kidney disease (CKD). Methods: A total of 41 CKD patients (18 males and 23 females; mean age, 65.2 years; range, 42 to 85 years) with a low glomerular filtration rate who did not require renal replacement therapy were included in this prospective study. Patients were followed up with laboratory assays at bimonthly intervals and with ultrasonography performed twice a year. Renal cortical thickness, renal length, and estimated glomerular filtration rate (eGFR) values were compared using the paired-samples t test. Additionally, Pearson correlation analysis was conducted between renal length and cortical thickness measurements and eGFR values to assess kidney function. Results: At the beginning of the study and after 24 months, mean eGFR values of the 41 patients were 35.92 mL/min and 28.38 mL/min, respectively. The mean renal length was 91.29 mm at the beginning of the study and 90.24 mm at the end of the study. The mean cortical thickness was 5.76 +/- 2.05 mm at the beginning of the study and 5.28 +/- 1.99 mm at the end of the study. A statistically significant positive association was found between eGFR and mean renal length (r= 0.66, P< 0.01) and between eGFR and mean cortical thickness (r= 0.85, P< 0.01), with the latter being more prominent. Conclusion: Our study suggests that ultrasonographic cortical thickness measurements may be an important imaging technique in the follow-up care of patients with CKD

Co-occurrence of inflammatory fibroid polyp in Crohn's disease: A MR enterography study

WOS: 000357334100015PubMed ID: 2603901

Computed tomography evaluation of pancreatic steatosis: correlation with COVID-19 prognosis

Tweetable abstract In COVID-19 patients, the patients with fatty pancreas assessed using computed tomography have a more severe clinical course, higher rates of hospitalization/ICU requirement and increased length of hospitalization compared with the patients without fatty pancreas. #COVID-19 #computed tomography #fatty pancreas. Aim: To investigate the relationship between pancreatic steatosis (PS) assessed on computed tomography (CT) and COVID-19 prognosis. Materials & methods: This retrospective study covers 396 patients with COVID-19 (mean age: 52.50 +/- 16.86 years), who underwent unenhanced chest CT. PS was compared with clinical findings, comorbidities, requirements for hospitalization, intubation and intensive care unit (ICU), length of hospitalization and death. Results: PS was found to be strongly correlated with the severity of clinical findings and hospitalization rates (p < 0.001). In hospitalized patients, length of hospitalization (p = 0.002) and rates of ICU requirement (p = 0.003) were higher in patients with PS. Conclusion: PS, correlated with clinical severity and hospitalization requirement, is an independent risk factor for COVID-19. Plain language summary Fat accumulation in the pancreas that is associated with obesity and metabolic syndrome can be used for estimating the clinical course of patients with COVID-19. Fat accumulation was determined by comparing the pancreas and spleen using computed tomography tools. In our study with 396 COVID-19 patients, the patients with fatty pancreas clearly seemed to have more severe clinical findings. Similarly, the rates of the requirement for hospitalization/intensive care unit and length of hospitalization were higher than in patients without fatty pancreas. The median length of hospitalization was 9 days in patients with fatty pancreas and 6 days in patients without fatty pancreas. However, death rates were only slightly higher in patients with fatty pancreas

Computed tomography evaluation of pancreatic steatosis: correlation with COVID-19 prognosis

Tweetable abstract In COVID-19 patients, the patients with fatty pancreas assessed using computed tomography have a more severe clinical course, higher rates of hospitalization/ICU requirement and increased length of hospitalization compared with the patients without fatty pancreas. #COVID-19 #computed tomography #fatty pancreas. Aim: To investigate the relationship between pancreatic steatosis (PS) assessed on computed tomography (CT) and COVID-19 prognosis. Materials ; methods: This retrospective study covers 396 patients with COVID-19 (mean age: 52.50 +/- 16.86 years), who underwent unenhanced chest CT. PS was compared with clinical findings, comorbidities, requirements for hospitalization, intubation and intensive care unit (ICU), length of hospitalization and death. Results: PS was found to be strongly correlated with the severity of clinical findings and hospitalization rates (p 0.001). In hospitalized patients, length of hospitalization (p = 0.002) and rates of ICU requirement (p = 0.003) were higher in patients with PS. Conclusion: PS, correlated with clinical severity and hospitalization requirement, is an independent risk factor for COVID-19. Plain language summary Fat accumulation in the pancreas that is associated with obesity and metabolic syndrome can be used for estimating the clinical course of patients with COVID-19. Fat accumulation was determined by comparing the pancreas and spleen using computed tomography tools. In our study with 396 COVID-19 patients, the patients with fatty pancreas clearly seemed to have more severe clinical findings. Similarly, the rates of the requirement for hospitalization/intensive care unit and length of hospitalization were higher than in patients without fatty pancreas. The median length of hospitalization was 9 days in patients with fatty pancreas and 6 days in patients without fatty pancreas. However, death rates were only slightly higher in patients with fatty pancreas